SE466223B - Anordning och foerfarande foer att bestaemma den linjaera sekvensen av aminosyraenheter i proteiner och peptider - Google Patents

Anordning och foerfarande foer att bestaemma den linjaera sekvensen av aminosyraenheter i proteiner och peptider

Info

Publication number
SE466223B
SE466223B SE8105597A SE8105597A SE466223B SE 466223 B SE466223 B SE 466223B SE 8105597 A SE8105597 A SE 8105597A SE 8105597 A SE8105597 A SE 8105597A SE 466223 B SE466223 B SE 466223B
Authority
SE
Sweden
Prior art keywords
chamber
sample
matrix
valve
fluids
Prior art date
Application number
SE8105597A
Other languages
English (en)
Swedish (sv)
Other versions
SE8105597L (sv
Inventor
L E Hood
M W Hunkapiller
W J Dreyer
R M Hewick
A W Stark
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of SE8105597L publication Critical patent/SE8105597L/xx
Publication of SE466223B publication Critical patent/SE466223B/sv

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00Feed or outlet devices; Feed or outlet control devices
    • B01J4/02Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16KVALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/14Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
    • F16K7/17Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00283Reactor vessels with top opening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00281Individual reactor vessels
    • B01J2219/00286Reactor vessels with top and bottom openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00389Feeding through valves
    • B01J2219/00396Membrane valves
    • B01J2219/00398Membrane valves in multiple arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00418Means for dispensing and evacuation of reagents using pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00423Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00495Means for heating or cooling the reaction vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/0059Sequential processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00695Synthesis control routines, e.g. using computer programs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SE8105597A 1980-09-23 1981-09-22 Anordning och foerfarande foer att bestaemma den linjaera sekvensen av aminosyraenheter i proteiner och peptider SE466223B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19010080A 1980-09-23 1980-09-23

Publications (2)

Publication Number Publication Date
SE8105597L SE8105597L (sv) 1982-05-06
SE466223B true SE466223B (sv) 1992-01-13

Family

ID=22700018

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8105597A SE466223B (sv) 1980-09-23 1981-09-22 Anordning och foerfarande foer att bestaemma den linjaera sekvensen av aminosyraenheter i proteiner och peptider
SE8802124A SE501968C2 (sv) 1980-09-23 1988-06-07 Omvandlingskolv
SE8802125A SE8802125A0 (sv) 1980-09-23 1988-06-07 Ventilanordning

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE8802124A SE501968C2 (sv) 1980-09-23 1988-06-07 Omvandlingskolv
SE8802125A SE8802125A0 (sv) 1980-09-23 1988-06-07 Ventilanordning

Country Status (6)

Country Link
JP (1) JPS57110962A (enrdf_load_stackoverflow)
CA (1) CA1163425A (enrdf_load_stackoverflow)
DE (1) DE3137875C2 (enrdf_load_stackoverflow)
FR (1) FR2490505B1 (enrdf_load_stackoverflow)
GB (3) GB2084899B (enrdf_load_stackoverflow)
SE (3) SE466223B (enrdf_load_stackoverflow)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (fr) * 1983-04-19 1987-11-27 California Inst Of Techn Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
DE3425763A1 (de) * 1983-07-13 1985-01-24 Nippon Zeon Co., Ltd., Tokio/Tokyo Verfahren zur synthese von polynukleotiden
JPS60105691A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
CA1218930A (en) * 1984-02-22 1987-03-10 Allelix Biopharmaceuticals Inc. Device for performing quantitative chemical and immunochemical assays
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
DE3508162C1 (de) * 1985-03-07 1986-06-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Leitungssystem fuer Laboratoriumszwecke
DE3750624T2 (de) * 1986-08-15 1995-02-16 Beckmann Research Inst Of The Durchlaufreaktor für Peptidsequenatoren.
US4773446A (en) * 1986-08-27 1988-09-27 Porton Instruments, Inc. Valve block assembly
DE3637869A1 (de) * 1986-11-06 1988-05-19 Draegerwerk Ag Mehrfachhalterung fuer pruefroehrchen
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
EP0388224A3 (en) * 1989-03-17 1991-05-22 Seiko Instruments Inc. Method and apparatus for effecting chemical treatment
JPH02307059A (ja) * 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5605839A (en) * 1990-04-11 1997-02-25 Ludwig Institute For Cancer Research Methods and apparatus for use in sequential chemical reactions
DE9109797U1 (de) * 1991-08-07 1991-09-26 Wissenschaftliche Gerätebau Dr.-Ing. Herbert Knauer GmbH, 1000 Berlin Gerät zur Durchführung von chemischen Prozessen an einer Probe eines chemischen Materials
IT1255014B (it) * 1992-03-27 1995-10-13 Instrumentation Lab Spa Dispositivi di movimentazione ed intercettazione di fluidi
US5203368A (en) * 1992-07-29 1993-04-20 Protein Technologies Inc. Matrix of valves
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
DE19652823A1 (de) * 1996-12-18 1998-03-26 Guenter Prof Dr Fuhr Strukturierter Polytetrafluorethylen-Spacer
GB2409411A (en) * 2003-12-22 2005-06-29 William Thomas Dennis Bates Blood collection system
AU2012315883A1 (en) * 2011-09-30 2014-04-17 Ge Healthcare Limited Reactor for multi-step radiochemistry

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077766A (en) 1960-07-08 1963-02-19 Phillips Petroleum Co Shut off valve for chromatographic system
DE1227855B (de) * 1960-07-12 1966-11-03 Ichthyol Ges Verfahren zur Herstellung von Enzymkoerpern fuer die Durchfuehrung enzymatischer Reaktionen
US3717436A (en) 1971-01-25 1973-02-20 Beckman Ind Inc Process for the sequential degradation of peptide chains
BE786213A (fr) * 1971-07-13 1973-01-15 Technicon Instr Procede et appareil pour l'analyse d'echantillons, notamment desang
US3725010A (en) 1971-08-23 1973-04-03 Beckman Instruments Inc Apparatus for automatically performing chemical processes
BE795316A (fr) * 1972-02-11 1973-05-29 Nat Patent Dev Corp Systeme catalytique presentant une activite enzymatique durable et de stabilite augmentee
JPS5117438B2 (enrdf_load_stackoverflow) * 1972-05-26 1976-06-02
GB1427192A (en) * 1972-05-26 1976-03-10 Kannegiesser M Apparatus for manufacturing mouldings from expandable synthetic plastics more particularly polyurethane
DE2308088C2 (de) * 1973-02-19 1983-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur automatisierten Bestimmung der Aminosäuresequenz und Vorrichtung zu ihrer Durchführung
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US3959307A (en) 1974-02-15 1976-05-25 Wittmann Brigitte Method to determine automatically the sequence of amino acids
US3951167A (en) 1974-12-05 1976-04-20 E. I. Du Pont De Nemours And Company Fluid handling assembly
US4065412A (en) * 1976-05-07 1977-12-27 Durrum Instrument Corporation Peptide or protein sequencing method and apparatus
US4119120A (en) 1976-11-29 1978-10-10 Beckman Instruments, Inc. Fluid switch
US4252769A (en) * 1979-12-26 1981-02-24 California Institute Of Technology Apparatus for the performance of chemical processes

Also Published As

Publication number Publication date
GB2084899A (en) 1982-04-21
JPH0256635B2 (enrdf_load_stackoverflow) 1990-11-30
SE501968C2 (sv) 1995-07-03
GB2146741B (en) 1985-11-20
GB8333305D0 (en) 1984-01-18
GB8333306D0 (en) 1984-01-18
DE3137875A1 (de) 1982-05-06
DE3137875C2 (de) 1995-11-02
CA1163425A (en) 1984-03-13
SE8802125D0 (sv) 1988-06-07
FR2490505B1 (fr) 1986-01-03
GB2146550A (en) 1985-04-24
SE8802124D0 (sv) 1988-06-07
SE8802124L (enrdf_load_stackoverflow) 1988-06-07
FR2490505A1 (fr) 1982-03-26
GB2146550B (en) 1985-11-13
GB2146741A (en) 1985-04-24
SE8802125A0 (sv) 1988-06-07
SE8105597L (sv) 1982-05-06
JPS57110962A (en) 1982-07-10
GB2084899B (en) 1985-05-30

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