GB2084899B - Apparatus and method for the sequential performance of chemical processes - Google Patents

Apparatus and method for the sequential performance of chemical processes

Info

Publication number
GB2084899B
GB2084899B GB8127343A GB8127343A GB2084899B GB 2084899 B GB2084899 B GB 2084899B GB 8127343 A GB8127343 A GB 8127343A GB 8127343 A GB8127343 A GB 8127343A GB 2084899 B GB2084899 B GB 2084899B
Authority
GB
United Kingdom
Prior art keywords
chemical processes
sequential performance
sequential
performance
chemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8127343A
Other versions
GB2084899A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of GB2084899A publication Critical patent/GB2084899A/en
Application granted granted Critical
Publication of GB2084899B publication Critical patent/GB2084899B/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
    • F16K7/17—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B01J2219/00398—Membrane valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
GB8127343A 1980-09-23 1981-09-10 Apparatus and method for the sequential performance of chemical processes Expired GB2084899B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19010080A 1980-09-23 1980-09-23

Publications (2)

Publication Number Publication Date
GB2084899A GB2084899A (en) 1982-04-21
GB2084899B true GB2084899B (en) 1985-05-30

Family

ID=22700018

Family Applications (3)

Application Number Title Priority Date Filing Date
GB8127343A Expired GB2084899B (en) 1980-09-23 1981-09-10 Apparatus and method for the sequential performance of chemical processes
GB08333305A Expired GB2146741B (en) 1980-09-23 1983-12-14 Valve apparatus
GB08333306A Expired GB2146550B (en) 1980-09-23 1983-12-14 Conversion flask

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB08333305A Expired GB2146741B (en) 1980-09-23 1983-12-14 Valve apparatus
GB08333306A Expired GB2146550B (en) 1980-09-23 1983-12-14 Conversion flask

Country Status (6)

Country Link
JP (1) JPS57110962A (en)
CA (1) CA1163425A (en)
DE (1) DE3137875C2 (en)
FR (1) FR2490505B1 (en)
GB (3) GB2084899B (en)
SE (3) SE466223B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (en) * 1983-04-19 1987-11-27 California Inst Of Techn IMPROVED INSTALLATION AND METHOD FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS, IN PARTICULAR OLIGONUCLEOTIDES
DE3425763A1 (en) * 1983-07-13 1985-01-24 Nippon Zeon Co., Ltd., Tokio/Tokyo Method for the synthesis of polynucleotides
JPS60105691A (en) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd Apparatus for synthesizing polynucleotide
CA1218930A (en) * 1984-02-22 1987-03-10 Allelix Biopharmaceuticals Inc. Device for performing quantitative chemical and immunochemical assays
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
DE3508162C1 (en) * 1985-03-07 1986-06-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Pipe system for laboratory purposes
DE3750624T2 (en) * 1986-08-15 1995-02-16 Beckmann Research Inst Of The Continuous reactor for peptide sequencers.
US4773446A (en) * 1986-08-27 1988-09-27 Porton Instruments, Inc. Valve block assembly
DE3637869A1 (en) * 1986-11-06 1988-05-19 Draegerwerk Ag MULTIPLE HOLDER FOR TEST TUBES
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
EP0388224A3 (en) * 1989-03-17 1991-05-22 Seiko Instruments Inc. Method and apparatus for effecting chemical treatment
JPH02307059A (en) * 1989-05-23 1990-12-20 Seiko Instr Inc Reaction vessel
US5605839A (en) * 1990-04-11 1997-02-25 Ludwig Institute For Cancer Research Methods and apparatus for use in sequential chemical reactions
DE9109797U1 (en) * 1991-08-07 1991-09-26 Wissenschaftliche Gerätebau Dr.-Ing. Herbert Knauer GmbH, 1000 Berlin Device for carrying out chemical processes on a sample of a chemical material
IT1255014B (en) * 1992-03-27 1995-10-13 Instrumentation Lab Spa FLUIDS HANDLING AND INTERCEPTION DEVICES
US5203368A (en) * 1992-07-29 1993-04-20 Protein Technologies Inc. Matrix of valves
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
DE19652823A1 (en) * 1996-12-18 1998-03-26 Guenter Prof Dr Fuhr Three dimension micro-system spacers
GB2409411A (en) * 2003-12-22 2005-06-29 William Thomas Dennis Bates Blood collection system
JP2014534896A (en) * 2011-09-30 2014-12-25 ジーイー・ヘルスケア・リミテッド Multistage radiochemical reactor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077766A (en) 1960-07-08 1963-02-19 Phillips Petroleum Co Shut off valve for chromatographic system
DE1227855B (en) * 1960-07-12 1966-11-03 Ichthyol Ges Process for the production of enzyme bodies for the implementation of enzymatic reactions
US3717436A (en) 1971-01-25 1973-02-20 Beckman Ind Inc Process for the sequential degradation of peptide chains
BE786213A (en) * 1971-07-13 1973-01-15 Technicon Instr METHOD AND APPARATUS FOR THE ANALYSIS OF SAMPLES, IN PARTICULAR DESANG
US3725010A (en) 1971-08-23 1973-04-03 Beckman Instruments Inc Apparatus for automatically performing chemical processes
BE795316A (en) * 1972-02-11 1973-05-29 Nat Patent Dev Corp CATALYTIC SYSTEM PRESENTING SUSTAINABLE ENZYMATIC ACTIVITY AND INCREASED STABILITY
GB1427192A (en) * 1972-05-26 1976-03-10 Kannegiesser M Apparatus for manufacturing mouldings from expandable synthetic plastics more particularly polyurethane
JPS5117438B2 (en) * 1972-05-26 1976-06-02
DE2308088C2 (en) * 1973-02-19 1983-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Process for the automated determination of the amino acid sequence and device for its implementation
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US3959307A (en) 1974-02-15 1976-05-25 Wittmann Brigitte Method to determine automatically the sequence of amino acids
US3951167A (en) 1974-12-05 1976-04-20 E. I. Du Pont De Nemours And Company Fluid handling assembly
US4065412A (en) * 1976-05-07 1977-12-27 Durrum Instrument Corporation Peptide or protein sequencing method and apparatus
US4119120A (en) 1976-11-29 1978-10-10 Beckman Instruments, Inc. Fluid switch
US4252769A (en) * 1979-12-26 1981-02-24 California Institute Of Technology Apparatus for the performance of chemical processes

Also Published As

Publication number Publication date
SE8802124D0 (en) 1988-06-07
SE8802125D0 (en) 1988-06-07
SE8802125A0 (en) 1988-06-07
SE8105597L (en) 1982-05-06
CA1163425A (en) 1984-03-13
SE466223B (en) 1992-01-13
GB2146741B (en) 1985-11-20
JPS57110962A (en) 1982-07-10
DE3137875A1 (en) 1982-05-06
GB2146550B (en) 1985-11-13
DE3137875C2 (en) 1995-11-02
SE8802124L (en) 1988-06-07
FR2490505B1 (en) 1986-01-03
GB2146550A (en) 1985-04-24
GB2084899A (en) 1982-04-21
GB2146741A (en) 1985-04-24
GB8333305D0 (en) 1984-01-18
SE501968C2 (en) 1995-07-03
JPH0256635B2 (en) 1990-11-30
GB8333306D0 (en) 1984-01-18
FR2490505A1 (en) 1982-03-26

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20010909