DE3129444A1 - "sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel" - Google Patents

"sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel"

Info

Publication number
DE3129444A1
DE3129444A1 DE19813129444 DE3129444A DE3129444A1 DE 3129444 A1 DE3129444 A1 DE 3129444A1 DE 19813129444 DE19813129444 DE 19813129444 DE 3129444 A DE3129444 A DE 3129444A DE 3129444 A1 DE3129444 A1 DE 3129444A1
Authority
DE
Germany
Prior art keywords
group
carbon atoms
butoxy
general formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813129444
Other languages
German (de)
English (en)
Inventor
Walter Dr. Haarmann
Erich Dipl.-Chem. Dr. Müller
Berthold Dipl.-Chem. Dr. Narr
Josef Dipl.-Chem. Dr. Nickl
Josef Dipl.-Chem. Dr. Roch
Johannes Maximilian Dipl.-Chem. Dr. 7950 Biberach Weisenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19813129444 priority Critical patent/DE3129444A1/de
Priority to NO822255A priority patent/NO822255L/no
Priority to US06/395,631 priority patent/US4442111A/en
Priority to SU823463928A priority patent/SU1158041A3/ru
Priority to DE8282106501T priority patent/DE3264556D1/de
Priority to EP82106501A priority patent/EP0071150B1/de
Priority to AT82106501T priority patent/ATE14120T1/de
Priority to YU01581/82A priority patent/YU158182A/xx
Priority to FI822550A priority patent/FI822550A7/fi
Priority to PH27592A priority patent/PH17716A/en
Priority to AR290035A priority patent/AR230745A1/es
Priority to DD82241832A priority patent/DD202871A5/de
Priority to PL1982237600A priority patent/PL137725B1/pl
Priority to CS825591A priority patent/CS236488B2/cs
Priority to PT75297A priority patent/PT75297A/pt
Priority to HU822373A priority patent/HU188188B/hu
Priority to DK329582A priority patent/DK329582A/da
Priority to IE1782/82A priority patent/IE53471B1/en
Priority to JP57128814A priority patent/JPS5824559A/ja
Priority to ZA825273A priority patent/ZA825273B/xx
Priority to GR68840A priority patent/GR76181B/el
Priority to AU86378/82A priority patent/AU556082B2/en
Priority to IL66384A priority patent/IL66384A/xx
Priority to NZ201363A priority patent/NZ201363A/en
Priority to GB08221294A priority patent/GB2104515B/en
Priority to ES514275A priority patent/ES8305333A1/es
Priority to CA000407915A priority patent/CA1175430A/en
Priority to KR1019820003316A priority patent/KR840000491A/ko
Priority to DE19823246980 priority patent/DE3246980A1/de
Priority to ES518826A priority patent/ES518826A0/es
Priority to ES518828A priority patent/ES518828A0/es
Priority to ES518827A priority patent/ES8400411A1/es
Publication of DE3129444A1 publication Critical patent/DE3129444A1/de
Priority to US06/573,964 priority patent/US4551464A/en
Priority to PH30677A priority patent/PH20662A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19813129444 1981-07-25 1981-07-25 "sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel" Withdrawn DE3129444A1 (de)

Priority Applications (34)

Application Number Priority Date Filing Date Title
DE19813129444 DE3129444A1 (de) 1981-07-25 1981-07-25 "sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel"
NO822255A NO822255L (no) 1981-07-25 1982-06-30 Fremgangsmaate for fremstilling av terapeutisk aktive sulfimin-derivater.
US06/395,631 US4442111A (en) 1981-07-25 1982-07-06 Antithrombotic sulfimino and sulfoximino indolinones-2
SU823463928A SU1158041A3 (ru) 1981-07-25 1982-07-16 Способ получени производных сульфимина
DE8282106501T DE3264556D1 (en) 1981-07-25 1982-07-19 Sulfimines, their salts and their preparation, and pharmaceutical compositions containing them
EP82106501A EP0071150B1 (de) 1981-07-25 1982-07-19 Sulfimine, deren Salze und deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
AT82106501T ATE14120T1 (de) 1981-07-25 1982-07-19 Sulfimine, deren salze und deren herstellung sowie diese verbindungen enthaltende arzneimittel.
YU01581/82A YU158182A (en) 1981-07-25 1982-07-20 Process for preparing new sulfimizines
FI822550A FI822550A7 (fi) 1981-07-25 1982-07-20 Sulfimiinit, niiden suolat ja niiden valmistus sekä näitä yhdisteitä sisältävt lääkeaineet.
PH27592A PH17716A (en) 1981-07-25 1982-07-20 Antithrombotic sulfimino and sulfoximino indolinones-2
AR290035A AR230745A1 (es) 1981-07-25 1982-07-21 Procedimiento para la preparacion de nuevos derivados de(sulfoximino o sulfimino)-alcoxi-quinclin-2-ona,(sulfoximino o sulfimino)alcoxi-3,4-dihidro-quinclin-2-ona y(sulfoximino o sulfimino-3,3-dialquil-indolin-2-ona
DD82241832A DD202871A5 (de) 1981-07-25 1982-07-21 Verfahren zur herstellung von sulfiminen
PL1982237600A PL137725B1 (en) 1981-07-25 1982-07-21 Method of obtaining novel sulfimines
CS825591A CS236488B2 (en) 1981-07-25 1982-07-22 Method of new suphimines production
PT75297A PT75297A (fr) 1981-07-25 1982-07-22 Procede pour la preparation de sulphimines et de compositions pharmaceutiques qui les contiennent
HU822373A HU188188B (en) 1981-07-25 1982-07-22 Process for producing new sulfimines containing quinoline scelet and salts thereof
DK329582A DK329582A (da) 1981-07-25 1982-07-22 Sulfiminer eller salte deraf,fremgangsmaade til deres fremstilling,samt deres anvendelse
IE1782/82A IE53471B1 (en) 1981-07-25 1982-07-23 Sulphimines
CA000407915A CA1175430A (en) 1981-07-25 1982-07-23 Sulphimines, the salts thereof and preparation thereof and pharmaceutical compositions containing these compounds
ZA825273A ZA825273B (en) 1981-07-25 1982-07-23 Sulphimines,processes for their preparation,and pharmaceutical compositions thereof
GR68840A GR76181B (enExample) 1981-07-25 1982-07-23
AU86378/82A AU556082B2 (en) 1981-07-25 1982-07-23 Sulphoximino-quinolin-2-one (indolin-2-one) derivatives
IL66384A IL66384A (en) 1981-07-25 1982-07-23 Indolin-2-one(3,4-dihydroquinol-2-one or quinol-2-one)-oxyalkylsulphimines and salts thereof,their preparation and pharmaceutical compositions containing them
NZ201363A NZ201363A (en) 1981-07-25 1982-07-23 Sulphimine derivatives,and pharmaceutical compositions containing such
GB08221294A GB2104515B (en) 1981-07-25 1982-07-23 Sulphimines
ES514275A ES8305333A1 (es) 1981-07-25 1982-07-23 "procedimiento para la preparacion de nuevas sulfiminas".
JP57128814A JPS5824559A (ja) 1981-07-25 1982-07-23 新規スルフイミン化合物
KR1019820003316A KR840000491A (ko) 1981-07-25 1982-07-24 설피민의 제조방법
DE19823246980 DE3246980A1 (de) 1981-07-25 1982-12-18 Verfahren zur herstellung von sulfoximinen
ES518826A ES518826A0 (es) 1981-07-25 1983-01-07 Procedimiento para la preparacion de nuevas sulfiminas.
ES518828A ES518828A0 (es) 1981-07-25 1983-01-07 Procedimiento para la preparacion de nuevas sulfiminas.
ES518827A ES8400411A1 (es) 1981-07-25 1983-01-07 Procedimiento para la preparacion de nuevas sulfiminas.
US06/573,964 US4551464A (en) 1981-07-25 1984-01-26 Antithrombotic sulfoximino carbostyrils
PH30677A PH20662A (en) 1981-07-25 1984-05-16 Antithrombotic sulfiximino carbostyrils

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813129444 DE3129444A1 (de) 1981-07-25 1981-07-25 "sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel"

Publications (1)

Publication Number Publication Date
DE3129444A1 true DE3129444A1 (de) 1983-02-10

Family

ID=6137766

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19813129444 Withdrawn DE3129444A1 (de) 1981-07-25 1981-07-25 "sulfoximine, deren herstellung und diese verbindungen enthaltende arzneimittel"
DE19823246980 Withdrawn DE3246980A1 (de) 1981-07-25 1982-12-18 Verfahren zur herstellung von sulfoximinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19823246980 Withdrawn DE3246980A1 (de) 1981-07-25 1982-12-18 Verfahren zur herstellung von sulfoximinen

Country Status (19)

Country Link
JP (1) JPS5824559A (enExample)
KR (1) KR840000491A (enExample)
AR (1) AR230745A1 (enExample)
AU (1) AU556082B2 (enExample)
CA (1) CA1175430A (enExample)
CS (1) CS236488B2 (enExample)
DD (1) DD202871A5 (enExample)
DE (2) DE3129444A1 (enExample)
DK (1) DK329582A (enExample)
ES (4) ES8305333A1 (enExample)
FI (1) FI822550A7 (enExample)
GR (1) GR76181B (enExample)
HU (1) HU188188B (enExample)
NO (1) NO822255L (enExample)
PL (1) PL137725B1 (enExample)
PT (1) PT75297A (enExample)
SU (1) SU1158041A3 (enExample)
YU (1) YU158182A (enExample)
ZA (1) ZA825273B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2247579B1 (en) * 2008-01-17 2012-04-18 Bayer Pharma Aktiengesellschaft Sulphoximine-substituted quinazoline derivatives as immunomodulators, their preparation and use as medicaments

Also Published As

Publication number Publication date
DE3246980A1 (de) 1984-06-20
AU556082B2 (en) 1986-10-23
DD202871A5 (de) 1983-10-05
SU1158041A3 (ru) 1985-05-23
ES518827A0 (es) 1983-10-16
FI822550L (fi) 1983-01-26
PL237600A1 (en) 1983-03-28
CS236488B2 (en) 1985-05-15
PL137725B1 (en) 1986-07-31
ES8400412A1 (es) 1983-10-16
JPS5824559A (ja) 1983-02-14
KR840000491A (ko) 1984-02-22
ES8400410A1 (es) 1983-10-16
ES518828A0 (es) 1983-10-16
ES518826A0 (es) 1983-10-16
AU8637882A (en) 1983-04-14
CA1175430A (en) 1984-10-02
PT75297A (fr) 1982-08-01
ZA825273B (en) 1984-03-28
ES514275A0 (es) 1983-04-01
ES8400411A1 (es) 1983-10-16
YU158182A (en) 1984-08-31
FI822550A0 (fi) 1982-07-20
HU188188B (en) 1986-03-28
ES8305333A1 (es) 1983-04-01
GR76181B (enExample) 1984-08-03
AR230745A1 (es) 1984-06-29
NO822255L (no) 1983-01-26
FI822550A7 (fi) 1983-01-26
DK329582A (da) 1983-01-26

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