DE3069559D1 - Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use - Google Patents
Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical useInfo
- Publication number
- DE3069559D1 DE3069559D1 DE8080105019T DE3069559T DE3069559D1 DE 3069559 D1 DE3069559 D1 DE 3069559D1 DE 8080105019 T DE8080105019 T DE 8080105019T DE 3069559 T DE3069559 T DE 3069559T DE 3069559 D1 DE3069559 D1 DE 3069559D1
- Authority
- DE
- Germany
- Prior art keywords
- carbolin
- beta
- carboxylic acid
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8080105019T DE3069559D1 (en) | 1979-08-29 | 1980-08-23 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK362279 | 1979-08-29 | ||
DK88980A DK88980A (da) | 1980-02-29 | 1980-02-29 | Beta-carbonline-3-carboxylsyrederivater og fremgangsmaader til fremstilling af samme |
DE19803015816 DE3015816A1 (de) | 1980-04-22 | 1980-04-22 | 4-substituierte- (beta) -carbolin-3-carbonsaeurederivate, ihre herstellung und verwendung |
DE19803023567 DE3023567A1 (de) | 1980-06-20 | 1980-06-20 | Substituierte (beta) -carbolin-3-carbonsaeurederivate |
DE8080105019T DE3069559D1 (en) | 1979-08-29 | 1980-08-23 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3069559D1 true DE3069559D1 (en) | 1984-12-06 |
Family
ID=27432526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8080105019T Expired DE3069559D1 (en) | 1979-08-29 | 1980-08-23 | Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use |
Country Status (16)
Country | Link |
---|---|
US (2) | US4371536A (fr) |
EP (1) | EP0030254B1 (fr) |
CA (1) | CA1150246A (fr) |
DD (1) | DD152935A5 (fr) |
DE (1) | DE3069559D1 (fr) |
ES (1) | ES494590A0 (fr) |
FI (1) | FI68829C (fr) |
HU (1) | HU186744B (fr) |
IE (1) | IE50229B1 (fr) |
IL (1) | IL60906A (fr) |
NO (1) | NO155055C (fr) |
NZ (1) | NZ194747A (fr) |
PL (1) | PL226479A1 (fr) |
PT (1) | PT71744B (fr) |
RO (1) | RO80265B (fr) |
YU (1) | YU215580A (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
DE3240513A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung |
DE3240514A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DK149270C (da) * | 1983-05-27 | 1986-08-25 | Schering Ag | Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater |
DE3322895A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s) |
DE3322894A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h) |
DE3335323A1 (de) * | 1983-09-27 | 1985-04-04 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
FR2555988A1 (fr) * | 1983-12-06 | 1985-06-07 | Centre Nat Rech Scient | Derive de b-carbolines, procede pour leurs preparations et medicament les contenant |
DK240184D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
DE3535928A1 (de) * | 1985-10-04 | 1987-04-09 | Schering Ag | Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3545776A1 (de) * | 1985-12-20 | 1987-06-25 | Schering Ag | 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
DE3609699A1 (de) * | 1986-03-20 | 1987-09-24 | Schering Ag | 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester |
DE3608089A1 (de) * | 1986-03-08 | 1987-09-10 | Schering Ag | Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel |
EP0285671B1 (fr) * | 1986-10-13 | 2003-09-03 | Asahi Kasei Kabushiki Kaisha | Derives de pyridine |
DE4029389A1 (de) * | 1990-09-13 | 1992-03-26 | Schering Ag | Verfahren zur herstellung von (beta)-carbolin-derivaten |
US5350750A (en) * | 1991-04-27 | 1994-09-27 | Schering Aktiengesellschaft | β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents |
GB9508195D0 (en) * | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
AU710079B2 (en) * | 1996-04-04 | 1999-09-16 | F. Hoffmann-La Roche Ag | Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents |
DK0923581T3 (da) * | 1996-08-09 | 2003-08-04 | Boehringer Ingelheim Pharma | 4-substituerede beta-carboliner som immunmodulatorer |
UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
AR036040A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
ES2383001T3 (es) | 2001-10-02 | 2012-06-15 | Pharmacia & Upjohn Company Llc | Compuestos de heteroarilo condensado sustituidos con azabicíclico para el tratamiento de enfermedades |
EP1442037A1 (fr) | 2001-11-09 | 2004-08-04 | PHARMACIA & UPJOHN COMPANY | Composes heterocycliques fusionnes avec un groupe phenyl-azabicyclique et leur utilisation en tant que ligands de recepteur nachr alpha 7 |
US20030176456A1 (en) * | 2001-12-21 | 2003-09-18 | June Harry L. | Methods for reducing alcohol cravings in chronic alcoholics |
AU2003219690A1 (en) | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
PA8586801A1 (es) * | 2002-10-31 | 2005-02-04 | Pfizer | Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso |
BRPI0407052A (pt) * | 2003-01-27 | 2006-01-17 | Pfizer | Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização |
CN100503607C (zh) * | 2003-06-02 | 2009-06-24 | 新疆华世丹药物研究有限责任公司 | 去氢骆驼蓬碱衍生物类化合物及其应用 |
CA2563761C (fr) * | 2004-04-26 | 2009-12-29 | Pfizer Inc. | Inhibiteurs de l'enzyme integrase du vih |
EP1756103A2 (fr) | 2004-04-26 | 2007-02-28 | Pfizer, Inc. | Dérivés de pyrrolopyridine et leur utilisation comme inhibiteurs de l'integrase du vih |
EA200800758A1 (ru) * | 2005-10-07 | 2008-08-29 | Пфайзер Продактс Инк. | Ингибиторы фермента интегразы вич |
BRPI0718089A2 (pt) | 2006-10-28 | 2013-11-05 | Methylgene Inc | Composto, uso do composto, composição, e, métodos para inibir histona desacetilase e para tratar uma doença de expansão da poliglutamina |
AU2013205135B2 (en) * | 2006-10-28 | 2015-11-05 | Forum Pharmaceuticals Inc. | Inhibitors of histone deacetylase |
US8268854B2 (en) | 2008-05-22 | 2012-09-18 | The Uwm Research Foundation, Inc. | Aza-beta-carbolines and methods of using same |
CN104211699A (zh) * | 2013-06-05 | 2014-12-17 | 首都医科大学 | β-咔啉衍生物,其制备,纳米结构,抗肿瘤活性和应用 |
CN104628722B (zh) * | 2015-01-30 | 2016-06-22 | 华南农业大学 | 一种骆驼蓬碱酰胺类化合物及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA786351A (en) * | 1968-05-28 | Leonard Frederick | PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLIN-CARBOXYLIC ACID AMIDE DERIVATIVES | |
ES273769A1 (es) * | 1961-01-18 | 1962-06-01 | Geigy Ag J R | Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico |
GB1084256A (fr) * | 1963-11-06 | |||
NZ194747A (en) * | 1979-08-29 | 1988-11-29 | Schering Ag | 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives |
JPS57123180A (en) * | 1980-12-17 | 1982-07-31 | Schering Ag | 3-substituted beta-carboline, manufacture and psychotropic drug containing same |
DE3322894A1 (de) * | 1983-06-23 | 1985-01-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h) |
DK240184D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | Beta-carboline-3-carboxylic acid derivatives and method of preparing the same |
DK240084D0 (da) * | 1984-05-15 | 1984-05-15 | Ferrosan As | New beta-carboline-3-oxadiazolyl derivatives |
DE3504045A1 (de) * | 1985-02-04 | 1986-08-07 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von ss-carbolinen durch dehydrierung |
-
1980
- 1980-08-22 NZ NZ194747A patent/NZ194747A/xx unknown
- 1980-08-23 DE DE8080105019T patent/DE3069559D1/de not_active Expired
- 1980-08-23 EP EP80105019A patent/EP0030254B1/fr not_active Expired
- 1980-08-25 IL IL60906A patent/IL60906A/xx unknown
- 1980-08-27 RO RO102050A patent/RO80265B/ro unknown
- 1980-08-27 PT PT71744A patent/PT71744B/pt unknown
- 1980-08-28 NO NO802546A patent/NO155055C/no unknown
- 1980-08-28 YU YU02155/80A patent/YU215580A/xx unknown
- 1980-08-28 HU HU802129A patent/HU186744B/hu unknown
- 1980-08-28 IE IE1806/80A patent/IE50229B1/en not_active IP Right Cessation
- 1980-08-28 US US06/182,244 patent/US4371536A/en not_active Expired - Lifetime
- 1980-08-28 FI FI802720A patent/FI68829C/fi not_active IP Right Cessation
- 1980-08-28 CA CA000359184A patent/CA1150246A/fr not_active Expired
- 1980-08-29 DD DD80223673A patent/DD152935A5/de unknown
- 1980-08-29 PL PL22647980A patent/PL226479A1/xx unknown
- 1980-08-29 ES ES494590A patent/ES494590A0/es active Granted
-
1988
- 1988-04-25 US US07/188,145 patent/US5010077A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0030254A1 (fr) | 1981-06-17 |
FI802720A (fi) | 1981-03-01 |
IL60906A0 (en) | 1980-10-26 |
PL226479A1 (fr) | 1981-10-30 |
RO80265B (ro) | 1983-04-30 |
NO155055B (no) | 1986-10-27 |
PT71744B (en) | 1981-06-08 |
EP0030254B1 (fr) | 1984-10-31 |
IE801806L (en) | 1981-02-28 |
NZ194747A (en) | 1988-11-29 |
FI68829C (fi) | 1985-11-11 |
IE50229B1 (en) | 1986-03-05 |
US5010077A (en) | 1991-04-23 |
CA1150246A (fr) | 1983-07-19 |
RO80265A (fr) | 1983-04-29 |
ES8106305A1 (es) | 1981-08-16 |
NO802546L (no) | 1981-03-02 |
IL60906A (en) | 1985-11-29 |
ES494590A0 (es) | 1981-08-16 |
PT71744A (en) | 1980-09-01 |
HU186744B (en) | 1985-09-30 |
US4371536A (en) | 1983-02-01 |
FI68829B (fi) | 1985-07-31 |
NO155055C (no) | 1987-02-04 |
DD152935A5 (de) | 1981-12-16 |
YU215580A (en) | 1984-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SCHERING AG, 13353 BERLIN, DE |
|
8330 | Complete renunciation |