DE3065181D1 - Cephalosporin derivatives, their preparation and their use - Google Patents

Cephalosporin derivatives, their preparation and their use

Info

Publication number
DE3065181D1
DE3065181D1 DE8080303525T DE3065181T DE3065181D1 DE 3065181 D1 DE3065181 D1 DE 3065181D1 DE 8080303525 T DE8080303525 T DE 8080303525T DE 3065181 T DE3065181 T DE 3065181T DE 3065181 D1 DE3065181 D1 DE 3065181D1
Authority
DE
Germany
Prior art keywords
preparation
cephalosporin derivatives
cephalosporin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080303525T
Other languages
German (de)
English (en)
Inventor
Billy Grinnell Jackson
Donna Nezich Nee Nezic Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3065181D1 publication Critical patent/DE3065181D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080303525T 1979-10-09 1980-10-07 Cephalosporin derivatives, their preparation and their use Expired DE3065181D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
DE3065181D1 true DE3065181D1 (en) 1983-11-10

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080303525T Expired DE3065181D1 (en) 1979-10-09 1980-10-07 Cephalosporin derivatives, their preparation and their use

Country Status (27)

Country Link
US (1) US4252951A (show.php)
EP (1) EP0027050B1 (show.php)
JP (1) JPS5661388A (show.php)
KR (1) KR840000866B1 (show.php)
AT (1) AT369008B (show.php)
AU (1) AU6306180A (show.php)
BE (1) BE885569A (show.php)
CA (1) CA1146539A (show.php)
CH (1) CH647523A5 (show.php)
CS (1) CS215142B2 (show.php)
DD (1) DD153375A5 (show.php)
DE (1) DE3065181D1 (show.php)
DK (1) DK424680A (show.php)
ES (1) ES8201166A1 (show.php)
FI (1) FI803200A7 (show.php)
FR (1) FR2467211A1 (show.php)
GB (1) GB2059966B (show.php)
GR (1) GR70219B (show.php)
HU (1) HU183230B (show.php)
IE (1) IE50390B1 (show.php)
IL (1) IL61227A (show.php)
IT (1) IT1132926B (show.php)
PH (1) PH15023A (show.php)
PT (1) PT71886B (show.php)
RO (1) RO80664B (show.php)
YU (1) YU256480A (show.php)
ZA (1) ZA806192B (show.php)

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JPH07116200B2 (ja) * 1985-09-20 1995-12-13 富山化学工業株式会社 セファロスポリンの製造方法
JPH08831B2 (ja) * 1985-09-20 1996-01-10 富山化学工業株式会社 セファロスポリンの精製法
USD404431S (en) 1997-06-30 1999-01-19 Hilco Corporation Gumball dispenser
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EP1219607B1 (en) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
WO2001051454A1 (en) * 2000-01-13 2001-07-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CN1522148A (zh) * 2001-03-08 2004-08-18 ��Ϧ�������ݴ�ѧ���»� 作为抗感染药的表面两亲聚合物
MXPA04001831A (es) * 2001-08-29 2004-07-08 Neose Technologies Inc Nuevos derivados sinteticos de gangliosidos y composiciones de los mismos.
AU2003264430B2 (en) * 2002-09-19 2009-03-19 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivative, addition salt thereof, and immunosuppressant
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
KR101241176B1 (ko) * 2003-03-17 2013-03-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 표면적으로 양쪽성인 중합체 및 올리고머 및 이의 용도
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20050203184A1 (en) * 2003-09-10 2005-09-15 Petasis Nicos A. Benzo lipoxin analogues
CN1922133A (zh) * 2004-01-23 2007-02-28 宾夕法尼亚州大学理事会 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途
CN1976892A (zh) * 2004-05-06 2007-06-06 加利福尼亚大学董事会 取代烯胺酮、它们的衍生物及其应用
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
AU2006218805A1 (en) * 2005-02-25 2006-09-08 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer
US7893304B2 (en) * 2005-02-28 2011-02-22 Meiji Dairies Corporation Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals comprising the same
AU2006279943B2 (en) * 2005-08-10 2012-02-16 The Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
WO2007020227A1 (de) * 2005-08-15 2007-02-22 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von betamimetika
WO2007053343A2 (en) * 2005-10-28 2007-05-10 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1954259A2 (en) * 2005-11-29 2008-08-13 Hammersmith Imanet, Ltd Amidine derivatives for in vivo imaging
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
FR2902996B1 (fr) * 2006-07-03 2008-09-26 Oreal Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide
FR2903004B1 (fr) * 2006-07-03 2009-07-10 Oreal Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
AU2007334428B2 (en) * 2006-12-14 2014-05-29 Teva Pharmaceutical Industries, Ltd. Crystalline solid rasagiline base
CN101730706B (zh) * 2007-05-11 2015-04-15 生物科技研究有限公司 具有神经保护和增强记忆活性的受体拮抗剂
US7696383B2 (en) * 2007-06-26 2010-04-13 Solvay Pharmaceuticals B.V. N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs
FR2920000B1 (fr) * 2007-08-13 2010-01-29 Oreal Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement
EP2212277B1 (en) * 2007-10-19 2016-08-31 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
NZ584716A (en) * 2007-10-19 2011-12-22 Janssen Pharmaceutica Nv PIPERIDINYL AND PIPERAZINYL MODULATORS OF gamma-SECRETASE
ES2401833T3 (es) * 2007-10-19 2013-04-24 Janssen Pharmaceutica, N.V. Moduladores enlazados de carbono de y-secretasa
EP2093207A1 (en) * 2008-02-06 2009-08-26 Julius-Maximilians-Universität Würzburg Antiinfective and antitumoral compounds isolated from tropical lianas
US8063249B1 (en) * 2008-04-25 2011-11-22 Olema Pharmaceuticals, Inc. Substituted triphenyl butenes
US20100056475A1 (en) * 2008-08-06 2010-03-04 Alexander Chucholowski Cyclodextrin conjugates
KR101546562B1 (ko) * 2008-10-22 2015-08-25 어큐셀라 인코포레이티드 안과 질환 및 장애 치료용 화합물
FR2940610B1 (fr) * 2008-12-30 2011-05-06 Oreal Association de monosaccharides avec des derives c-glycosides et son utilisation en cosmetique
EP3175857A1 (en) 2009-03-25 2017-06-07 Seneb Biosciences Inc. Glycolipids as treatment for disease
UA108986C2 (uk) * 2009-05-14 2015-07-10 Мілленніум Фармасьютікалз, Інк. Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти)
US8962639B2 (en) * 2009-05-29 2015-02-24 Abbvie Inc. Potassium channel modulators
US8288592B2 (en) * 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
WO2012067824A1 (en) 2010-11-16 2012-05-24 Abbott Laboratories Potassium channel modulators
WO2013036403A1 (en) * 2011-09-06 2013-03-14 Curna, Inc. TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
GR63088B (en) 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins

Also Published As

Publication number Publication date
IL61227A0 (en) 1980-12-31
KR840000866B1 (ko) 1984-06-20
AU6306180A (en) 1981-04-16
ZA806192B (en) 1982-05-26
IE802086L (en) 1981-04-09
FI803200L (fi) 1981-04-10
DK424680A (da) 1981-04-10
BE885569A (fr) 1981-04-08
ES495753A0 (es) 1981-12-01
GB2059966A (en) 1981-04-29
ATA498080A (de) 1982-04-15
EP0027050B1 (en) 1983-10-05
PT71886A (en) 1980-11-01
FR2467211B1 (show.php) 1983-06-10
ES8201166A1 (es) 1981-12-01
EP0027050A1 (en) 1981-04-15
AT369008B (de) 1982-11-25
PH15023A (en) 1982-05-13
GB2059966B (en) 1983-09-01
CS215142B2 (en) 1982-07-30
PT71886B (en) 1981-08-13
RO80664A (ro) 1983-02-15
CH647523A5 (fr) 1985-01-31
US4252951A (en) 1981-02-24
JPS5661388A (en) 1981-05-26
RO80664B (ro) 1983-02-28
DD153375A5 (de) 1982-01-06
KR830004314A (ko) 1983-07-09
FI803200A7 (fi) 1981-04-10
HU183230B (en) 1984-04-28
FR2467211A1 (fr) 1981-04-17
IE50390B1 (en) 1986-04-16
IT8025200A0 (it) 1980-10-08
YU256480A (en) 1983-02-28
GR70219B (show.php) 1982-08-31
CA1146539A (en) 1983-05-17
IL61227A (en) 1983-07-31
IT1132926B (it) 1986-07-09

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee