DE3000521A1 - Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung - Google Patents
Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellungInfo
- Publication number
- DE3000521A1 DE3000521A1 DE19803000521 DE3000521A DE3000521A1 DE 3000521 A1 DE3000521 A1 DE 3000521A1 DE 19803000521 DE19803000521 DE 19803000521 DE 3000521 A DE3000521 A DE 3000521A DE 3000521 A1 DE3000521 A1 DE 3000521A1
- Authority
- DE
- Germany
- Prior art keywords
- substance
- interferon
- andrejewski
- honke
- partner
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
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- 239000004599 antimicrobial Substances 0.000 description 1
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- PWLNAUNEAKQYLH-UHFFFAOYSA-N butyric acid octyl ester Natural products CCCCCCCCOC(=O)CCC PWLNAUNEAKQYLH-UHFFFAOYSA-N 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- GHNBEBDYYSVNEK-UHFFFAOYSA-N capillon Natural products CC=CC=CC(=O)C1=CC=CC=C1 GHNBEBDYYSVNEK-UHFFFAOYSA-N 0.000 description 1
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- 238000012754 cardiac puncture Methods 0.000 description 1
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- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 1
- 229940117948 caryophyllene Drugs 0.000 description 1
- RSYBQKUNBFFNDO-UHFFFAOYSA-N caryophyllene oxide Natural products CC1(C)CC2C(=C)CCC3OC3(C)CCC12C RSYBQKUNBFFNDO-UHFFFAOYSA-N 0.000 description 1
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- 229960005233 cineole Drugs 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
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- 239000003937 drug carrier Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
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- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- UBLXEEBHYISRFM-UHFFFAOYSA-M folin's reagent Chemical compound [Na+].C1=CC=C2C(S(=O)(=O)[O-])=CC(=O)C(=O)C2=C1 UBLXEEBHYISRFM-UHFFFAOYSA-M 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- XMCTYDOFFXSNQJ-UHFFFAOYSA-N hexadecyl(methyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[NH2+]C XMCTYDOFFXSNQJ-UHFFFAOYSA-N 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- UHZJRKGDIXMHFS-UHFFFAOYSA-N isoartemisia ketone Natural products CC(=C)CC(=O)C(C)(C)C=C UHZJRKGDIXMHFS-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
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- 230000003449 preventive effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940074353 santonin Drugs 0.000 description 1
- 150000007659 semicarbazones Chemical class 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- USDOQCCMRDNVAH-UHFFFAOYSA-N sigma-cadinene Natural products C1C=C(C)CC2C(C(C)C)CC=C(C)C21 USDOQCCMRDNVAH-UHFFFAOYSA-N 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
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- 210000000952 spleen Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- QZZGJDVWLFXDLK-UHFFFAOYSA-N tetracosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCC(O)=O QZZGJDVWLFXDLK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
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- 230000003253 viricidal effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- USDOQCCMRDNVAH-KKUMJFAQSA-N β-cadinene Chemical compound C1C=C(C)C[C@H]2[C@H](C(C)C)CC=C(C)[C@@H]21 USDOQCCMRDNVAH-KKUMJFAQSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54001540A JPS6011891B2 (ja) | 1979-01-10 | 1979-01-10 | インタ−フエロン誘起剤の製造方法 |
JP16008979A JPS5683496A (en) | 1979-12-10 | 1979-12-10 | Interferon inducer and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3000521A1 true DE3000521A1 (de) | 1980-07-24 |
Family
ID=26334774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19803000521 Withdrawn DE3000521A1 (de) | 1979-01-10 | 1980-01-09 | Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE3000521A1 (enrdf_load_stackoverflow) |
FR (1) | FR2446110A1 (enrdf_load_stackoverflow) |
GB (1) | GB2042555B (enrdf_load_stackoverflow) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3004018A1 (de) * | 1979-02-07 | 1980-08-21 | Kitasato Inst | Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung |
DE4415539A1 (de) * | 1994-05-03 | 1994-11-17 | Osama Dr Dr Med Omer | Pflanzliches Arzneimittel mit virustatischer und antiviraler Wirkung |
WO2003022294A3 (de) * | 2001-09-11 | 2003-09-12 | Josef Beuth | Extrakt erhältlich aus artemisia abrotanum l. (eberraute) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0030444B1 (en) * | 1979-12-03 | 1985-01-30 | Kitasato Kenkyusho | A process for preparing substances having interferon inducing activity |
DE3067048D1 (en) * | 1979-12-03 | 1984-04-19 | Kitasato Inst | A process for preparing substances having interferon inducing activity and interferon inducers |
FR2623397B1 (fr) * | 1987-11-19 | 1993-08-13 | Cosnier Alain | Composition medicamenteuse a base de plantes a usage interne |
US5411733A (en) * | 1992-04-27 | 1995-05-02 | Hozumi; Toyoharu | Antiviral agent containing crude drug |
-
1980
- 1980-01-09 DE DE19803000521 patent/DE3000521A1/de not_active Withdrawn
- 1980-01-10 GB GB8000904A patent/GB2042555B/en not_active Expired
- 1980-01-10 FR FR8000473A patent/FR2446110A1/fr active Granted
Non-Patent Citations (2)
Title |
---|
Hagers Handbuch der pharmazeutischen Praxis, Bd. 3, S. 256, 259, 274 u. 276, 1972 * |
O. Geßner, Die Gift- und Arzneipflanzen von Mitteleuropa, S. 383-388, Heidelberg 1953 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3004018A1 (de) * | 1979-02-07 | 1980-08-21 | Kitasato Inst | Substanz mit interferon induzierender aktivitaet sowie verfahren zu ihrer herstellung |
DE4415539A1 (de) * | 1994-05-03 | 1994-11-17 | Osama Dr Dr Med Omer | Pflanzliches Arzneimittel mit virustatischer und antiviraler Wirkung |
WO2003022294A3 (de) * | 2001-09-11 | 2003-09-12 | Josef Beuth | Extrakt erhältlich aus artemisia abrotanum l. (eberraute) |
Also Published As
Publication number | Publication date |
---|---|
FR2446110A1 (fr) | 1980-08-08 |
GB2042555B (en) | 1983-03-09 |
GB2042555A (en) | 1980-09-24 |
FR2446110B1 (enrdf_load_stackoverflow) | 1983-07-08 |
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OAP | Request for examination filed | ||
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8139 | Disposal/non-payment of the annual fee |