DE2945636A1 - Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellung - Google Patents
Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellungInfo
- Publication number
- DE2945636A1 DE2945636A1 DE19792945636 DE2945636A DE2945636A1 DE 2945636 A1 DE2945636 A1 DE 2945636A1 DE 19792945636 DE19792945636 DE 19792945636 DE 2945636 A DE2945636 A DE 2945636A DE 2945636 A1 DE2945636 A1 DE 2945636A1
- Authority
- DE
- Germany
- Prior art keywords
- salts
- heparin
- compounds
- formula
- stable solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920000669 heparin Polymers 0.000 title claims description 27
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims description 23
- 229960002897 heparin Drugs 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 12
- -1 class of aliphatic diamines Chemical class 0.000 claims description 5
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 150000002897 organic nitrogen compounds Chemical class 0.000 claims description 2
- 241000277284 Salvelinus fontinalis Species 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 5
- 229960001008 heparin sodium Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000008215 water for injection Substances 0.000 description 4
- 229960004704 dihydroergotamine Drugs 0.000 description 3
- ADYPXRFPBQGGAH-UMYZUSPBSA-N dihydroergotamine mesylate Chemical compound CS(O)(=O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C)C1=CC=CC=C1 ADYPXRFPBQGGAH-UMYZUSPBSA-N 0.000 description 3
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 3
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- WROUIBGUWODUPA-UHFFFAOYSA-N 2-(butylamino)-n-(2-chloro-6-methylphenyl)acetamide;hydrochloride Chemical compound [Cl-].CCCC[NH2+]CC(=O)NC1=C(C)C=CC=C1Cl WROUIBGUWODUPA-UHFFFAOYSA-N 0.000 description 1
- JZCZNTBTAPXSPB-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethanol;hydrate Chemical compound O.OCCOCCOCCO JZCZNTBTAPXSPB-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- JABXMSSGPHGCII-UHFFFAOYSA-N acetic acid;propane-1,2-diol Chemical compound CC(O)=O.CC(O)CO JABXMSSGPHGCII-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229960002242 chlorocresol Drugs 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 229950002475 mesilate Drugs 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (24)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792945636 DE2945636A1 (de) | 1979-11-12 | 1979-11-12 | Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellung |
| BE1/10018A BE886008A (fr) | 1979-11-12 | 1980-11-03 | Nouvelles solutions pharmaceutiques stables a base d'alcaloides de l'ergot de seigle hydrogenes et d'heparine et leur preparation |
| CH8192/80A CH650930A5 (de) | 1979-11-12 | 1980-11-04 | Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellung. |
| FI803456A FI72045C (fi) | 1979-11-12 | 1980-11-05 | Foerfarande foer framstaellning av en stabil loesning av dihydroergotaminmetansulfonat och natriumheparinat. |
| DE8080106843T DE3068719D1 (en) | 1979-11-12 | 1980-11-06 | Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations |
| EP80106843A EP0028813B1 (de) | 1979-11-12 | 1980-11-06 | Stabile Lösungen von hydrierten Ergotalkaloiden bzw. ihren Salzen und Heparin bzw. seinen Salzen sowie Verfahren zu deren Herstellung |
| CY1332A CY1332A (en) | 1979-11-12 | 1980-11-10 | Stable solutions of hydrogenated ergotalkaloids and heparin |
| PT72041A PT72041B (en) | 1979-11-12 | 1980-11-10 | Process for the preparation of a stable solution based on an hydrogenated alkaloyd from ergot of rye and heparin |
| IL61447A IL61447A (en) | 1979-11-12 | 1980-11-10 | Stable solutions of hydrogenated ergot alkaloids and heparin and their preparation |
| GR63321A GR72128B (enExample) | 1979-11-12 | 1980-11-10 | |
| PH24834A PH22800A (en) | 1979-11-12 | 1980-11-10 | Stable solutions of hydrogenated ergotalkaloids |
| DK477880A DK155144C (da) | 1979-11-12 | 1980-11-10 | Fremgangsmaade til fremstilling af stabile oploesninger af en blanding af hydrogenerede ergotalkaloider og heparin |
| GB8036009A GB2062468B (en) | 1979-11-12 | 1980-11-10 | Stable solutions of hydrogenated ergotalkaloids and heparin |
| AT0550480A AT371997B (de) | 1979-11-12 | 1980-11-10 | Verfahren zur herstellung von stabilen loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen |
| HU802692A HU183244B (en) | 1979-11-12 | 1980-11-10 | Process for preparing stable solutions containing hydrogenated ergot alkaloids and salts thereof resp. and heparin |
| CA000364330A CA1165692A (en) | 1979-11-12 | 1980-11-10 | Stable solutions of hydrogenated ergot alkaloids |
| AU64265/80A AU535357B2 (en) | 1979-11-12 | 1980-11-11 | Stable pharmaceutical solution |
| IE2340/80A IE50372B1 (en) | 1979-11-12 | 1980-11-11 | Stable solutions of hydrogenated egotalkaloids |
| JP15937680A JPS5686116A (en) | 1979-11-12 | 1980-11-11 | Stable solution of hydrogenated ergot alkaloids |
| ZA00807005A ZA807005B (en) | 1979-11-12 | 1980-11-12 | Stable solutions of hydrogenated ergotalkaloids |
| US06/317,660 US4402949A (en) | 1979-11-12 | 1981-11-02 | Stable solutions of hydrogenated ergotalkaloids |
| MY165/85A MY8500165A (en) | 1979-11-12 | 1985-12-30 | Stable solutions of hydrogenated ergotalkaloids |
| KE3623A KE3623A (en) | 1979-11-12 | 1986-04-14 | Stable solutions of hydrogenated ergotalkaloids |
| HK403/86A HK40386A (en) | 1979-11-12 | 1986-05-29 | Stable solutions of hydrogenated ergotalkaloids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792945636 DE2945636A1 (de) | 1979-11-12 | 1979-11-12 | Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2945636A1 true DE2945636A1 (de) | 1981-05-21 |
Family
ID=6085779
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792945636 Withdrawn DE2945636A1 (de) | 1979-11-12 | 1979-11-12 | Stabile loesungen von hydrierten ergotalkaloiden bzw. ihren salzen und heparin bzw. seinen salzen sowie verfahren zu deren herstellung |
| DE8080106843T Expired DE3068719D1 (en) | 1979-11-12 | 1980-11-06 | Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080106843T Expired DE3068719D1 (en) | 1979-11-12 | 1980-11-06 | Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0028813B1 (enExample) |
| JP (1) | JPS5686116A (enExample) |
| AT (1) | AT371997B (enExample) |
| AU (1) | AU535357B2 (enExample) |
| BE (1) | BE886008A (enExample) |
| CA (1) | CA1165692A (enExample) |
| CH (1) | CH650930A5 (enExample) |
| CY (1) | CY1332A (enExample) |
| DE (2) | DE2945636A1 (enExample) |
| DK (1) | DK155144C (enExample) |
| FI (1) | FI72045C (enExample) |
| GB (1) | GB2062468B (enExample) |
| GR (1) | GR72128B (enExample) |
| HK (1) | HK40386A (enExample) |
| HU (1) | HU183244B (enExample) |
| IE (1) | IE50372B1 (enExample) |
| IL (1) | IL61447A (enExample) |
| KE (1) | KE3623A (enExample) |
| MY (1) | MY8500165A (enExample) |
| PH (1) | PH22800A (enExample) |
| PT (1) | PT72041B (enExample) |
| ZA (1) | ZA807005B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT382514B (de) * | 1982-12-10 | 1987-03-10 | Sandoz Ag | Verfahren zur herstellung eines therapeutischen praeparates, enthaltend hydrierte ergotalkaloide und heparin |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3227122A1 (de) * | 1982-07-20 | 1984-01-26 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Stabile loesungen von mutterkornalkaloiden |
| DE3432661A1 (de) * | 1984-09-05 | 1986-03-06 | Albert Prof. Dr. 6907 Nußloch Landsberger | Carcinom-therapeutikum |
| AT381232B (de) * | 1985-05-13 | 1986-09-10 | Kwizda Fa F Johann | Verfahren zur herstellung stabiler fluessiger loesungen von ergolinderivaten |
| US20050129622A1 (en) * | 2002-06-20 | 2005-06-16 | Isabelle Rault | Nasal composition comprising a mucopolysaccharide and propylene glycol |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2735587A1 (de) * | 1977-08-06 | 1979-02-15 | Sandoz Ag | Stabile loesungen und verfahren zu deren herstellung |
| DE2809618A1 (de) * | 1978-03-06 | 1979-09-20 | Sandoz Ag | Neues therapeutisches praeparat und verfahren zu dessen herstellung |
| DE2625403A1 (de) * | 1976-06-05 | 1977-12-08 | Sandoz Ag | Neue therapeutische mischung und verfahren zu deren herstellung |
| DE2555481C3 (de) * | 1975-12-10 | 1985-10-03 | Sandoz-Patent-GmbH, 7850 Lörrach | Herstellung stabiler Tropflösungen von hydrierten Ergotalkaloiden |
| DE2945677A1 (de) * | 1979-11-12 | 1981-05-21 | Sandoz-Patent-GmbH, 7850 Lörrach | Verwendung eines zweikammersystems zur verabreichung einer antithrombotischen mischung |
-
1979
- 1979-11-12 DE DE19792945636 patent/DE2945636A1/de not_active Withdrawn
-
1980
- 1980-11-03 BE BE1/10018A patent/BE886008A/fr not_active IP Right Cessation
- 1980-11-04 CH CH8192/80A patent/CH650930A5/de not_active IP Right Cessation
- 1980-11-05 FI FI803456A patent/FI72045C/fi not_active IP Right Cessation
- 1980-11-06 EP EP80106843A patent/EP0028813B1/de not_active Expired
- 1980-11-06 DE DE8080106843T patent/DE3068719D1/de not_active Expired
- 1980-11-10 GR GR63321A patent/GR72128B/el unknown
- 1980-11-10 PT PT72041A patent/PT72041B/pt unknown
- 1980-11-10 CA CA000364330A patent/CA1165692A/en not_active Expired
- 1980-11-10 HU HU802692A patent/HU183244B/hu not_active IP Right Cessation
- 1980-11-10 AT AT0550480A patent/AT371997B/de not_active IP Right Cessation
- 1980-11-10 CY CY1332A patent/CY1332A/en unknown
- 1980-11-10 DK DK477880A patent/DK155144C/da not_active IP Right Cessation
- 1980-11-10 PH PH24834A patent/PH22800A/en unknown
- 1980-11-10 GB GB8036009A patent/GB2062468B/en not_active Expired
- 1980-11-10 IL IL61447A patent/IL61447A/xx unknown
- 1980-11-11 JP JP15937680A patent/JPS5686116A/ja active Granted
- 1980-11-11 AU AU64265/80A patent/AU535357B2/en not_active Ceased
- 1980-11-11 IE IE2340/80A patent/IE50372B1/en unknown
- 1980-11-12 ZA ZA00807005A patent/ZA807005B/xx unknown
-
1985
- 1985-12-30 MY MY165/85A patent/MY8500165A/xx unknown
-
1986
- 1986-04-14 KE KE3623A patent/KE3623A/xx unknown
- 1986-05-29 HK HK403/86A patent/HK40386A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT382514B (de) * | 1982-12-10 | 1987-03-10 | Sandoz Ag | Verfahren zur herstellung eines therapeutischen praeparates, enthaltend hydrierte ergotalkaloide und heparin |
Also Published As
| Publication number | Publication date |
|---|---|
| KE3623A (en) | 1986-05-16 |
| IE802340L (en) | 1981-05-12 |
| GB2062468B (en) | 1983-08-24 |
| AU535357B2 (en) | 1984-03-15 |
| AT371997B (de) | 1983-08-25 |
| ATA550480A (de) | 1983-01-15 |
| PT72041A (en) | 1980-12-01 |
| FI72045C (fi) | 1987-04-13 |
| CY1332A (en) | 1986-06-27 |
| FI803456L (fi) | 1981-05-13 |
| GR72128B (enExample) | 1983-09-16 |
| AU6426580A (en) | 1981-05-21 |
| EP0028813B1 (de) | 1984-07-25 |
| MY8500165A (en) | 1985-12-31 |
| GB2062468A (en) | 1981-05-28 |
| FI72045B (fi) | 1986-12-31 |
| ZA807005B (en) | 1982-06-30 |
| IL61447A0 (en) | 1980-12-31 |
| HK40386A (en) | 1986-06-06 |
| HU183244B (en) | 1984-04-28 |
| EP0028813A2 (de) | 1981-05-20 |
| CH650930A5 (de) | 1985-08-30 |
| PH22800A (en) | 1988-12-12 |
| DK155144C (da) | 1989-07-03 |
| PT72041B (en) | 1982-01-26 |
| DK477880A (da) | 1981-05-13 |
| JPH021126B2 (enExample) | 1990-01-10 |
| JPS5686116A (en) | 1981-07-13 |
| EP0028813A3 (en) | 1982-08-25 |
| IE50372B1 (en) | 1986-04-02 |
| DK155144B (da) | 1989-02-20 |
| IL61447A (en) | 1983-11-30 |
| CA1165692A (en) | 1984-04-17 |
| BE886008A (fr) | 1981-05-04 |
| DE3068719D1 (en) | 1984-08-30 |
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| Date | Code | Title | Description |
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| 8130 | Withdrawal |