GB2062468B - Stable solutions of hydrogenated ergotalkaloids and heparin - Google Patents

Stable solutions of hydrogenated ergotalkaloids and heparin

Info

Publication number
GB2062468B
GB2062468B GB8036009A GB8036009A GB2062468B GB 2062468 B GB2062468 B GB 2062468B GB 8036009 A GB8036009 A GB 8036009A GB 8036009 A GB8036009 A GB 8036009A GB 2062468 B GB2062468 B GB 2062468B
Authority
GB
United Kingdom
Prior art keywords
ergotalkaloids
heparin
hydrogenated
stable solutions
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8036009A
Other versions
GB2062468A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB2062468A publication Critical patent/GB2062468A/en
Application granted granted Critical
Publication of GB2062468B publication Critical patent/GB2062468B/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8036009A 1979-11-12 1980-11-10 Stable solutions of hydrogenated ergotalkaloids and heparin Expired GB2062468B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792945636 DE2945636A1 (en) 1979-11-12 1979-11-12 STABLE SOLUTIONS OF HYDRATED ERGOTAL CALOIDS OR YOUR SALTS AND HEPARIN OR ITS SALTS AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
GB2062468A GB2062468A (en) 1981-05-28
GB2062468B true GB2062468B (en) 1983-08-24

Family

ID=6085779

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8036009A Expired GB2062468B (en) 1979-11-12 1980-11-10 Stable solutions of hydrogenated ergotalkaloids and heparin

Country Status (22)

Country Link
EP (1) EP0028813B1 (en)
JP (1) JPS5686116A (en)
AT (1) AT371997B (en)
AU (1) AU535357B2 (en)
BE (1) BE886008A (en)
CA (1) CA1165692A (en)
CH (1) CH650930A5 (en)
CY (1) CY1332A (en)
DE (2) DE2945636A1 (en)
DK (1) DK155144C (en)
FI (1) FI72045C (en)
GB (1) GB2062468B (en)
GR (1) GR72128B (en)
HK (1) HK40386A (en)
HU (1) HU183244B (en)
IE (1) IE50372B1 (en)
IL (1) IL61447A (en)
KE (1) KE3623A (en)
MY (1) MY8500165A (en)
PH (1) PH22800A (en)
PT (1) PT72041B (en)
ZA (1) ZA807005B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227122A1 (en) * 1982-07-20 1984-01-26 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim STABLE SOLUTIONS OF MOTHER CORNAL CALOIDS
CH656533A5 (en) * 1982-12-10 1986-07-15 Sandoz Ag THERAPEUTIC PREPARATION CONTAINING HYDRATED ERGOTAL CALOIDS AND LOW MOLECULAR HEPARINE.
DE3432661A1 (en) * 1984-09-05 1986-03-06 Albert Prof. Dr. 6907 Nußloch Landsberger CARCINOM THERAPEUTIC
AT381232B (en) * 1985-05-13 1986-09-10 Kwizda Fa F Johann METHOD FOR PRODUCING STABLE LIQUID SOLUTIONS OF ERGOL DERIVATIVES
RU2005101331A (en) * 2002-06-20 2006-01-20 Новартис Консьюмер Хелс С.А. (Ch) Nasal Composition Including Mucopolysaccharide and Propylene Glycol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2735587A1 (en) * 1977-08-06 1979-02-15 Sandoz Ag STABLE SOLUTIONS AND METHOD FOR THEIR PRODUCTION
DE2625403A1 (en) * 1976-06-05 1977-12-08 Sandoz Ag Antithrombotic association of medicaments - contains heparin and an ergoline-(8)-carboxylic acid peptidic amide esp. dihydroergotamine opt. with polyvinyl pyrrolidone
DE2809618A1 (en) * 1978-03-06 1979-09-20 Sandoz Ag NEW THERAPEUTIC PREPARATION AND METHOD FOR THE PRODUCTION THEREOF
DE2555481C3 (en) * 1975-12-10 1985-10-03 Sandoz-Patent-GmbH, 7850 Lörrach Production of stable drop solutions of hydrogenated ergot alkaloids
DE2945677A1 (en) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Antithrombotic combination of di:hydro:ergotamine cpd. and heparin - administered using a two-chamber system syringe to avoid instability problems on prolonged storage

Also Published As

Publication number Publication date
DK477880A (en) 1981-05-13
CA1165692A (en) 1984-04-17
IL61447A0 (en) 1980-12-31
BE886008A (en) 1981-05-04
JPH021126B2 (en) 1990-01-10
EP0028813A3 (en) 1982-08-25
DK155144B (en) 1989-02-20
AT371997B (en) 1983-08-25
ATA550480A (en) 1983-01-15
HK40386A (en) 1986-06-06
EP0028813A2 (en) 1981-05-20
IE802340L (en) 1981-05-12
AU535357B2 (en) 1984-03-15
IL61447A (en) 1983-11-30
PH22800A (en) 1988-12-12
ZA807005B (en) 1982-06-30
DE2945636A1 (en) 1981-05-21
GR72128B (en) 1983-09-16
DE3068719D1 (en) 1984-08-30
HU183244B (en) 1984-04-28
AU6426580A (en) 1981-05-21
PT72041A (en) 1980-12-01
MY8500165A (en) 1985-12-31
FI803456L (en) 1981-05-13
JPS5686116A (en) 1981-07-13
GB2062468A (en) 1981-05-28
IE50372B1 (en) 1986-04-02
DK155144C (en) 1989-07-03
KE3623A (en) 1986-05-16
PT72041B (en) 1982-01-26
CY1332A (en) 1986-06-27
FI72045C (en) 1987-04-13
FI72045B (en) 1986-12-31
EP0028813B1 (en) 1984-07-25
CH650930A5 (en) 1985-08-30

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee