DE2943326C2 - - Google Patents
Info
- Publication number
- DE2943326C2 DE2943326C2 DE2943326A DE2943326A DE2943326C2 DE 2943326 C2 DE2943326 C2 DE 2943326C2 DE 2943326 A DE2943326 A DE 2943326A DE 2943326 A DE2943326 A DE 2943326A DE 2943326 C2 DE2943326 C2 DE 2943326C2
- Authority
- DE
- Germany
- Prior art keywords
- group
- carbon atoms
- groups
- methoxyphenyl
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 methylenedioxy groups Chemical group 0.000 claims description 161
- 125000004432 carbon atom Chemical group C* 0.000 claims description 147
- 150000001875 compounds Chemical class 0.000 claims description 76
- 125000000217 alkyl group Chemical group 0.000 claims description 74
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 34
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 27
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 25
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 23
- 125000005843 halogen group Chemical group 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 230000035935 pregnancy Effects 0.000 claims description 19
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 18
- 150000003852 triazoles Chemical class 0.000 claims description 18
- 125000002252 acyl group Chemical group 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 14
- 125000003277 amino group Chemical group 0.000 claims description 13
- 125000000304 alkynyl group Chemical group 0.000 claims description 12
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000001188 haloalkyl group Chemical group 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 claims description 9
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 239000011541 reaction mixture Substances 0.000 claims description 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 8
- 125000003282 alkyl amino group Chemical group 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 150000007513 acids Chemical class 0.000 claims description 7
- 125000004442 acylamino group Chemical group 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 150000003254 radicals Chemical class 0.000 claims description 6
- YMBDJZXDDKXBKT-UHFFFAOYSA-N 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound CCC1=CC=CC=C1C1=NN(C(=O)NC=2C=CC(C)=CC=2)C(C=2C=C(OC)C=CC=2)=N1 YMBDJZXDDKXBKT-UHFFFAOYSA-N 0.000 claims description 5
- 239000012948 isocyanate Substances 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- UHSJLXGCWNKHTI-UHFFFAOYSA-N 1-[3-(3-methoxyphenyl)-5-(2-methylphenyl)-1,2,4-triazol-1-yl]ethanone Chemical compound COC1=CC=CC(C2=NN(C(C=3C(=CC=CC=3)C)=N2)C(C)=O)=C1 UHSJLXGCWNKHTI-UHFFFAOYSA-N 0.000 claims description 3
- QENLJIHICRTGFW-UHFFFAOYSA-N N-(2-chlorophenyl)-5-(2-ethylphenyl)-3-(3-methoxyphenyl)-1,2,4-triazole-1-carboxamide Chemical compound ClC1=C(C=CC=C1)NC(=O)N1N=C(N=C1C1=C(C=CC=C1)CC)C1=CC(=CC=C1)OC QENLJIHICRTGFW-UHFFFAOYSA-N 0.000 claims description 3
- ZTMGUOTZGLOBSR-UHFFFAOYSA-N [2-[3-(3-methoxyphenyl)-1h-1,2,4-triazol-5-yl]phenyl]methyl acetate Chemical compound COC1=CC=CC(C=2N=C(NN=2)C=2C(=CC=CC=2)COC(C)=O)=C1 ZTMGUOTZGLOBSR-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 125000005336 allyloxy group Chemical group 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 3
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
- 150000002513 isocyanates Chemical class 0.000 claims description 3
- DYZNMUGQXBJYEQ-UHFFFAOYSA-N 1-[5-(2-ethylphenyl)-3-(3-methoxyphenyl)-1,2,4-triazol-1-yl]ethanone Chemical compound CCC1=CC=CC=C1C1=NC(C=2C=C(OC)C=CC=2)=NN1C(C)=O DYZNMUGQXBJYEQ-UHFFFAOYSA-N 0.000 claims description 2
- NSPMIYGKQJPBQR-CVMUNTFWSA-N 1h-1,2,4-triazole Chemical class [13CH]=1[15N]=[13CH][15NH][15N]=1 NSPMIYGKQJPBQR-CVMUNTFWSA-N 0.000 claims description 2
- XAEPZYWJGXHETK-UHFFFAOYSA-N 3-(3-methoxyphenyl)-5-(2-methylphenyl)-n-phenyl-1,2,4-triazole-1-carboxamide Chemical compound COC1=CC=CC(C2=NN(C(C=3C(=CC=CC=3)C)=N2)C(=O)NC=2C=CC=CC=2)=C1 XAEPZYWJGXHETK-UHFFFAOYSA-N 0.000 claims description 2
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 238000005904 alkaline hydrolysis reaction Methods 0.000 claims description 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 93
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 91
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 36
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 36
- 238000002844 melting Methods 0.000 description 35
- 230000008018 melting Effects 0.000 description 35
- 239000000203 mixture Substances 0.000 description 30
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 21
- 239000000243 solution Substances 0.000 description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 15
- 239000002904 solvent Substances 0.000 description 15
- 239000003208 petroleum Substances 0.000 description 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 12
- GXCZZAKPGMYPDJ-UHFFFAOYSA-N 5-(2-ethylphenyl)-3-(3-methoxyphenyl)-1h-1,2,4-triazole Chemical compound CCC1=CC=CC=C1C1=NC(C=2C=C(OC)C=CC=2)=NN1 GXCZZAKPGMYPDJ-UHFFFAOYSA-N 0.000 description 11
- 125000003944 tolyl group Chemical group 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- JWAMHAADNHBVOK-UHFFFAOYSA-N 3-(3-methoxyphenyl)-5-(2-methylphenyl)-1h-1,2,4-triazole Chemical compound COC1=CC=CC(C=2N=C(NN=2)C=2C(=CC=CC=2)C)=C1 JWAMHAADNHBVOK-UHFFFAOYSA-N 0.000 description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 8
- 210000003754 fetus Anatomy 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 6
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 6
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- 238000005917 acylation reaction Methods 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 238000002513 implantation Methods 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 239000003960 organic solvent Substances 0.000 description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 6
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 230000010933 acylation Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 125000001309 chloro group Chemical group Cl* 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 241000699800 Cricetinae Species 0.000 description 4
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 4
- 229960002903 benzyl benzoate Drugs 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 239000008159 sesame oil Substances 0.000 description 4
- 235000011803 sesame oil Nutrition 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- MGYGFNQQGAQEON-UHFFFAOYSA-N 4-tolyl isocyanate Chemical compound CC1=CC=C(N=C=O)C=C1 MGYGFNQQGAQEON-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MGVOJXUEHOWQDM-UHFFFAOYSA-N 1-[2-(2-methylphenyl)-4-phenylimidazol-1-yl]ethanone Chemical compound CC(=O)N1C=C(C=2C=CC=CC=2)N=C1C1=CC=CC=C1C MGVOJXUEHOWQDM-UHFFFAOYSA-N 0.000 description 2
- HQAONQLFGHGEQA-UHFFFAOYSA-N 2-(2-methylphenyl)-5-phenyl-1h-imidazole Chemical compound CC1=CC=CC=C1C1=NC(C=2C=CC=CC=2)=CN1 HQAONQLFGHGEQA-UHFFFAOYSA-N 0.000 description 2
- BONDMBNDLAWZML-UHFFFAOYSA-N 3-(3-methoxyphenyl)-5-(2-methylphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound COC1=CC=CC(C2=NN(C(C=3C(=CC=CC=3)C)=N2)C(=O)NC=2C=CC(C)=CC=2)=C1 BONDMBNDLAWZML-UHFFFAOYSA-N 0.000 description 2
- AOBQVORYICVDOJ-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-(2-methylphenyl)-1h-1,2,4-triazole Chemical compound CC1=CC=CC=C1C1=NC(C=2C=CC(Cl)=CC=2)=NN1 AOBQVORYICVDOJ-UHFFFAOYSA-N 0.000 description 2
- PYPAPVPIYRECQS-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-(2-methylphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound C1=CC(C)=CC=C1NC(=O)N1C(C=2C(=CC=CC=2)C)=NC(C=2C=CC(Cl)=CC=2)=N1 PYPAPVPIYRECQS-UHFFFAOYSA-N 0.000 description 2
- YFPAVAXUTBXIAH-UHFFFAOYSA-N 3-(4-fluorophenyl)-5-(2-methylphenyl)-1h-1,2,4-triazole Chemical compound CC1=CC=CC=C1C1=NC(C=2C=CC(F)=CC=2)=NN1 YFPAVAXUTBXIAH-UHFFFAOYSA-N 0.000 description 2
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 description 2
- BAMLSZBEANVJGS-UHFFFAOYSA-N 5-(2-ethylphenyl)-3-(3-methoxyphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound CCC1=CC=CC=C1C1=NC(C=2C=C(OC)C=CC=2)=NN1C(=O)NC1=CC=C(C)C=C1 BAMLSZBEANVJGS-UHFFFAOYSA-N 0.000 description 2
- OIQAFEQPTNWKBP-UHFFFAOYSA-N 5-(3-methoxyphenyl)-3-(2-methylphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound COC1=CC=CC(C=2N(N=C(N=2)C=2C(=CC=CC=2)C)C(=O)NC=2C=CC(C)=CC=2)=C1 OIQAFEQPTNWKBP-UHFFFAOYSA-N 0.000 description 2
- QBLWDLQWKAZVGO-UHFFFAOYSA-N 5-(4-chlorophenyl)-3-(2-methylphenyl)-n-(4-methylphenyl)-1,2,4-triazole-1-carboxamide Chemical compound C1=CC(C)=CC=C1NC(=O)N1C(C=2C=CC(Cl)=CC=2)=NC(C=2C(=CC=CC=2)C)=N1 QBLWDLQWKAZVGO-UHFFFAOYSA-N 0.000 description 2
- KBSQCMLMRNIQOF-UHFFFAOYSA-N 5-(4-methoxy-2-methylphenyl)-3-(3-methoxyphenyl)-1h-1,2,4-triazole Chemical compound COC1=CC=CC(C=2N=C(NN=2)C=2C(=CC(OC)=CC=2)C)=C1 KBSQCMLMRNIQOF-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000282693 Cercopithecidae Species 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- 241000282520 Papio Species 0.000 description 2
- 235000019483 Peanut oil Nutrition 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 229910006080 SO2X Inorganic materials 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 150000008064 anhydrides Chemical class 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
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- HAMGRBXTJNITHG-UHFFFAOYSA-N methyl isocyanate Chemical compound CN=C=O HAMGRBXTJNITHG-UHFFFAOYSA-N 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- OFCCYDUUBNUJIB-UHFFFAOYSA-N n,n-diethylcarbamoyl chloride Chemical compound CCN(CC)C(Cl)=O OFCCYDUUBNUJIB-UHFFFAOYSA-N 0.000 description 1
- MFQCNSFIYAENKL-UHFFFAOYSA-N n-(4-chlorophenyl)-5-(2-ethylphenyl)-3-(3-methoxyphenyl)-1,2,4-triazole-1-carboxamide Chemical compound CCC1=CC=CC=C1C1=NC(C=2C=C(OC)C=CC=2)=NN1C(=O)NC1=CC=C(Cl)C=C1 MFQCNSFIYAENKL-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- FPLYNRPOIZEADP-UHFFFAOYSA-N octylsilane Chemical compound CCCCCCCC[SiH3] FPLYNRPOIZEADP-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000003828 vacuum filtration Methods 0.000 description 1
- 229940120293 vaginal suppository Drugs 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7842417 | 1978-10-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2943326A1 DE2943326A1 (de) | 1980-05-14 |
| DE2943326C2 true DE2943326C2 (is") | 1988-09-15 |
Family
ID=10500683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792943326 Granted DE2943326A1 (de) | 1978-10-30 | 1979-10-26 | Acyl-1h-1,2,4-triazolverbindungen, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die diese verbindungen enthalten |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4459302A (is") |
| JP (1) | JPS5562075A (is") |
| KR (1) | KR830002837B1 (is") |
| AT (1) | AT368754B (is") |
| AU (1) | AU533727B2 (is") |
| BE (1) | BE879732A (is") |
| CA (1) | CA1116610A (is") |
| CH (1) | CH642953A5 (is") |
| DE (1) | DE2943326A1 (is") |
| DK (1) | DK149470C (is") |
| ES (1) | ES485492A1 (is") |
| FI (1) | FI64151C (is") |
| FR (1) | FR2440364A1 (is") |
| GB (1) | GB2039887B (is") |
| GR (1) | GR69857B (is") |
| HK (1) | HK37183A (is") |
| IE (1) | IE49626B1 (is") |
| IL (1) | IL58520A (is") |
| IT (1) | IT1196401B (is") |
| LU (1) | LU81832A1 (is") |
| NL (1) | NL7907913A (is") |
| NO (1) | NO155134C (is") |
| NZ (1) | NZ191959A (is") |
| PH (1) | PH15419A (is") |
| PT (1) | PT70387A (is") |
| SE (1) | SE445453B (is") |
| YU (1) | YU265079A (is") |
| ZA (1) | ZA795798B (is") |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888350A (en) * | 1978-10-30 | 1989-12-19 | Gruppo Lepetit S.P.A. | New acyl-1H-1,2,4-triazole derivatives |
| AU557034B2 (en) * | 1981-10-20 | 1986-12-04 | Gruppo Lepetit S.P.A. | 3,5-diphenyl-1h-1,2,4-trazoles with contragestational |
| IT1292092B1 (it) * | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
| IT1292091B1 (it) * | 1997-06-05 | 1999-01-25 | Geange Ltd | Derivati eterociclici aromatici azotati,procedimento per la loro preparazione e loro impiego come antigestativi,immunosoppressori e |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308131A (en) * | 1962-12-06 | 1967-03-07 | Du Pont | Tertiary carbamyl triazoles |
| SU508198A3 (ru) * | 1971-07-22 | 1976-03-25 | Группо Лепетит С.П.А. (Фирма) | Способ получени производных 1,2,4-триазола |
| US4154841A (en) * | 1977-08-18 | 1979-05-15 | E. R. Squibb & Sons, Inc. | Antiinflammatory 1-acyl-3(5)-alkyl-5(3)-phenyl-1,2,4-triazoles |
-
1979
- 1979-10-16 FI FI793216A patent/FI64151C/fi not_active IP Right Cessation
- 1979-10-22 GR GR60317A patent/GR69857B/el unknown
- 1979-10-22 IL IL58520A patent/IL58520A/xx unknown
- 1979-10-23 US US06/087,375 patent/US4459302A/en not_active Expired - Lifetime
- 1979-10-23 AU AU52053/79A patent/AU533727B2/en not_active Ceased
- 1979-10-26 IE IE2068/79A patent/IE49626B1/en unknown
- 1979-10-26 DE DE19792943326 patent/DE2943326A1/de active Granted
- 1979-10-26 PH PH23219A patent/PH15419A/en unknown
- 1979-10-29 NO NO793477A patent/NO155134C/no unknown
- 1979-10-29 CH CH967379A patent/CH642953A5/fr not_active IP Right Cessation
- 1979-10-29 SE SE7908940A patent/SE445453B/sv not_active IP Right Cessation
- 1979-10-29 ZA ZA00795798A patent/ZA795798B/xx unknown
- 1979-10-29 ES ES485492A patent/ES485492A1/es not_active Expired
- 1979-10-29 NL NL7907913A patent/NL7907913A/nl not_active Application Discontinuation
- 1979-10-29 JP JP13971179A patent/JPS5562075A/ja active Granted
- 1979-10-29 DK DK456779A patent/DK149470C/da not_active IP Right Cessation
- 1979-10-29 IT IT26867/79A patent/IT1196401B/it active
- 1979-10-29 PT PT70387A patent/PT70387A/pt unknown
- 1979-10-29 LU LU81832A patent/LU81832A1/fr unknown
- 1979-10-29 NZ NZ191959A patent/NZ191959A/xx unknown
- 1979-10-29 AT AT0697279A patent/AT368754B/de not_active IP Right Cessation
- 1979-10-29 GB GB7937385A patent/GB2039887B/en not_active Expired
- 1979-10-30 CA CA000338699A patent/CA1116610A/en not_active Expired
- 1979-10-30 KR KR1019790003796A patent/KR830002837B1/ko not_active Expired
- 1979-10-30 BE BE0/197897A patent/BE879732A/fr not_active IP Right Cessation
- 1979-10-30 FR FR7926903A patent/FR2440364A1/fr active Granted
- 1979-10-30 YU YU02650/79A patent/YU265079A/xx unknown
-
1983
- 1983-09-21 HK HK371/83A patent/HK37183A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |