DE2849029A1 - Stabile valepotriat-zubereitungen und verfahren zu deren herstellung - Google Patents

Stabile valepotriat-zubereitungen und verfahren zu deren herstellung

Info

Publication number
DE2849029A1
DE2849029A1 DE19782849029 DE2849029A DE2849029A1 DE 2849029 A1 DE2849029 A1 DE 2849029A1 DE 19782849029 DE19782849029 DE 19782849029 DE 2849029 A DE2849029 A DE 2849029A DE 2849029 A1 DE2849029 A1 DE 2849029A1
Authority
DE
Germany
Prior art keywords
extract
valepotriate
preparations
mixture
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782849029
Other languages
German (de)
English (en)
Inventor
Werner Dr Rer Nat Althaus
Lutz Feicho
Martin Dr Rer Nat Wischniewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Pharmaceuticals GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Priority to DE19782849029 priority Critical patent/DE2849029A1/de
Priority to PT70276A priority patent/PT70276A/pt
Priority to MX10128279U priority patent/MX6398E/es
Priority to AT79104194T priority patent/ATE1880T1/de
Priority to EP79104194A priority patent/EP0011718B1/de
Priority to DE7979104194T priority patent/DE2964162D1/de
Priority to US06/089,718 priority patent/US4313930A/en
Priority to ES485842A priority patent/ES485842A0/es
Priority to CA000339583A priority patent/CA1139225A/en
Priority to JP14558579A priority patent/JPS5566508A/ja
Publication of DE2849029A1 publication Critical patent/DE2849029A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19782849029 1978-11-11 1978-11-11 Stabile valepotriat-zubereitungen und verfahren zu deren herstellung Withdrawn DE2849029A1 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DE19782849029 DE2849029A1 (de) 1978-11-11 1978-11-11 Stabile valepotriat-zubereitungen und verfahren zu deren herstellung
PT70276A PT70276A (fr) 1978-11-11 1979-10-04 Procede pour l'obtention de preparations de valepotriates stabilises
MX10128279U MX6398E (es) 1978-11-11 1979-10-10 Procedimiento para la elaboracion de preparaciones estables que contienen valepotriatos microencapsulados
AT79104194T ATE1880T1 (de) 1978-11-11 1979-10-29 Stabile valepotriat-zubereitungen und verfahren zu deren herstellung.
EP79104194A EP0011718B1 (de) 1978-11-11 1979-10-29 Stabile Valepotriat-Zubereitungen und Verfahren zu deren Herstellung
DE7979104194T DE2964162D1 (en) 1978-11-11 1979-10-29 Stable valepotriate compositions and methods of preparing the same
US06/089,718 US4313930A (en) 1978-11-11 1979-10-31 Stable valepotriate compounds and process for their preparation
ES485842A ES485842A0 (es) 1978-11-11 1979-11-08 Procedimiento para la obtencion de preparados de valepotria-tos en forma de microcapsulas.
CA000339583A CA1139225A (en) 1978-11-11 1979-11-09 Stable valepotriate compounds and process for their preparation
JP14558579A JPS5566508A (en) 1978-11-11 1979-11-12 Valepotiat medicine and its manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782849029 DE2849029A1 (de) 1978-11-11 1978-11-11 Stabile valepotriat-zubereitungen und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DE2849029A1 true DE2849029A1 (de) 1980-05-22

Family

ID=6054446

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782849029 Withdrawn DE2849029A1 (de) 1978-11-11 1978-11-11 Stabile valepotriat-zubereitungen und verfahren zu deren herstellung
DE7979104194T Expired DE2964162D1 (en) 1978-11-11 1979-10-29 Stable valepotriate compositions and methods of preparing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE7979104194T Expired DE2964162D1 (en) 1978-11-11 1979-10-29 Stable valepotriate compositions and methods of preparing the same

Country Status (8)

Country Link
US (1) US4313930A (enExample)
EP (1) EP0011718B1 (enExample)
JP (1) JPS5566508A (enExample)
AT (1) ATE1880T1 (enExample)
CA (1) CA1139225A (enExample)
DE (2) DE2849029A1 (enExample)
ES (1) ES485842A0 (enExample)
PT (1) PT70276A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654709A1 (de) * 1976-12-02 1978-06-08 Robins Co Inc A H Stabiles baldrianextraktpraeparat und verfahren zu seiner herstellung
GB2141930A (en) * 1983-06-22 1985-01-09 Kali Chemie Pharma Gmbh Novel pharmaceutical preparations with anti-tumour effect

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3327811A1 (de) * 1983-08-02 1985-02-21 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue valepotriathydrinhaltige arzneimittel
US5211948A (en) * 1988-10-12 1993-05-18 Nestec S.A. Process for the preparation of a powdered extract of valerian roots
IE61919B1 (en) * 1988-10-12 1994-11-30 Nestle Sa "Process for the preparation of a powdered extract of valerian roots"
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
CA2379395A1 (en) 1999-07-21 2001-02-01 Ancile Pharmaceuticals, Inc. Process for the extraction of valerian root
AU2992901A (en) * 2000-01-31 2001-08-07 University Of British Columbia, The Method for preparing and administering medicinal plant material
US20050003025A1 (en) * 2003-06-30 2005-01-06 Hargens Robert D. Method of mitigating the odor of valerian extracts
US20080124408A1 (en) * 2004-07-07 2008-05-29 Mediherb Holdings Ltd. Echinacea Formulation
EP3509611A4 (en) * 2016-09-08 2020-05-06 Laila Nutraceuticals Odor masking formulations for natural compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1266902A (fr) * 1960-09-06 1961-07-17 Procédé de production de préparations stables de vitamines
DE1191515B (de) * 1963-01-26 1965-04-22 Kali Chemie Ag Verfahren zur Gewinnung von sedativ und spasmolytisch wirksamen Estern aus Radix valerianae
US3869476A (en) * 1964-01-23 1975-03-04 Kali Chemie Ag Therapeutically active isovaleric acid esters
AU448795B2 (en) * 1969-08-22 1974-05-13 FUJI PHOTOFILM CO., LTD., and TOYO JOZO CO., LTD Enzyme-containing microcapsule and method of producing thesame
DE2230626B2 (de) * 1972-06-22 1978-07-20 Roland Dr. 7967 Bad Waldsee Schaette Baldrianpräparat
DE2654709C3 (de) * 1976-12-02 1987-07-09 A. H. Robins Co. Inc., Richmond, Va. Verfahren zum Stabilisieren von Baldrianextraktpräparaten

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654709A1 (de) * 1976-12-02 1978-06-08 Robins Co Inc A H Stabiles baldrianextraktpraeparat und verfahren zu seiner herstellung
GB2141930A (en) * 1983-06-22 1985-01-09 Kali Chemie Pharma Gmbh Novel pharmaceutical preparations with anti-tumour effect

Also Published As

Publication number Publication date
DE2964162D1 (en) 1983-01-05
ES8103971A1 (es) 1981-04-16
PT70276A (fr) 1979-11-01
JPS5566508A (en) 1980-05-20
CA1139225A (en) 1983-01-11
ES485842A0 (es) 1981-04-16
ATE1880T1 (de) 1982-12-15
JPH0134990B2 (enExample) 1989-07-21
EP0011718A1 (de) 1980-06-11
US4313930A (en) 1982-02-02
EP0011718B1 (de) 1982-12-01

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee