DE2837033A1 - Verfahren zur herstellung von podophyllinlignanlaktonen - Google Patents

Verfahren zur herstellung von podophyllinlignanlaktonen

Info

Publication number
DE2837033A1
DE2837033A1 DE19782837033 DE2837033A DE2837033A1 DE 2837033 A1 DE2837033 A1 DE 2837033A1 DE 19782837033 DE19782837033 DE 19782837033 DE 2837033 A DE2837033 A DE 2837033A DE 2837033 A1 DE2837033 A1 DE 2837033A1
Authority
DE
Germany
Prior art keywords
potassium
sodium
bisulfite
metabisulfite
thiosulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782837033
Other languages
German (de)
English (en)
Other versions
DE2837033C2 (https=
Inventor
Spaeter Genannt Werden Wird
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Publication of DE2837033A1 publication Critical patent/DE2837033A1/de
Application granted granted Critical
Publication of DE2837033C2 publication Critical patent/DE2837033C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19782837033 1977-08-25 1978-08-24 Verfahren zur herstellung von podophyllinlignanlaktonen Granted DE2837033A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/827,487 US4122092A (en) 1977-08-25 1977-08-25 Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone

Publications (2)

Publication Number Publication Date
DE2837033A1 true DE2837033A1 (de) 1979-03-22
DE2837033C2 DE2837033C2 (https=) 1988-04-21

Family

ID=25249348

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782837033 Granted DE2837033A1 (de) 1977-08-25 1978-08-24 Verfahren zur herstellung von podophyllinlignanlaktonen

Country Status (8)

Country Link
US (1) US4122092A (https=)
JP (1) JPS5495572A (https=)
CA (1) CA1088952A (https=)
CH (1) CH636870A5 (https=)
DE (1) DE2837033A1 (https=)
ES (1) ES472864A1 (https=)
GB (2) GB2017695B (https=)
IT (1) IT1106118B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
DE3476752D1 (en) * 1983-06-01 1989-03-23 Ciba Geigy Ag Process for the preparation of 2-arylbenzotriazoles
GB8424269D0 (en) * 1984-09-26 1984-10-31 Pharma Medica As Isolation and purification of podophyllotoxin
EP0207124B1 (en) * 1984-12-28 1991-10-09 Conpharm Ab Use of podophyllotoxin and derivatives thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6236371A (ja) * 1985-07-24 1987-02-17 Nichirei:Kk 新規抗菌性物質およびその製法
DE3530718A1 (de) * 1985-08-28 1987-03-12 Madaus & Co Dr Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten
AU632796B2 (en) * 1989-02-23 1993-01-14 University Of North Carolina At Chapel Hill, The Etoposide analogues
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
WO2009100349A1 (en) * 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524844A (en) * 1965-09-21 1970-08-18 Sandoz Ag Epipodophyllotoxin glucoside derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088621A (en) * 1963-12-12 1967-10-25 Sandoz Ltd Improvements in or relating to podophyllin derivatives
US4059593A (en) * 1975-12-22 1977-11-22 University Of Rochester Synthesis of steganacin and derivatives thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524844A (en) * 1965-09-21 1970-08-18 Sandoz Ag Epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
GB2003152A (en) 1979-03-07
JPS5495572A (en) 1979-07-28
ES472864A1 (es) 1979-10-16
US4122092A (en) 1978-10-24
GB2003152B (en) 1982-01-20
CH636870A5 (de) 1983-06-30
JPS6125033B2 (https=) 1986-06-13
DE2837033C2 (https=) 1988-04-21
GB2017695A (en) 1979-10-10
GB2017695B (en) 1982-01-20
CA1088952A (en) 1980-11-04
IT7850850A0 (it) 1978-08-24
IT1106118B (it) 1985-11-11

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee