IT1106118B - Procedimento per la produzione di-picropodofillone e suoi derivati sostituiti mediante sintesi totale - Google Patents
Procedimento per la produzione di-picropodofillone e suoi derivati sostituiti mediante sintesi totaleInfo
- Publication number
- IT1106118B IT1106118B IT50850/78A IT5085078A IT1106118B IT 1106118 B IT1106118 B IT 1106118B IT 50850/78 A IT50850/78 A IT 50850/78A IT 5085078 A IT5085078 A IT 5085078A IT 1106118 B IT1106118 B IT 1106118B
- Authority
- IT
- Italy
- Prior art keywords
- picropodophyllon
- procedure
- production
- total synthesis
- derivatives replaced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/827,487 US4122092A (en) | 1977-08-25 | 1977-08-25 | Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7850850A0 IT7850850A0 (it) | 1978-08-24 |
| IT1106118B true IT1106118B (it) | 1985-11-11 |
Family
ID=25249348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT50850/78A IT1106118B (it) | 1977-08-25 | 1978-08-24 | Procedimento per la produzione di-picropodofillone e suoi derivati sostituiti mediante sintesi totale |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4122092A (it) |
| JP (1) | JPS5495572A (it) |
| CA (1) | CA1088952A (it) |
| CH (1) | CH636870A5 (it) |
| DE (1) | DE2837033A1 (it) |
| ES (1) | ES472864A1 (it) |
| GB (2) | GB2017695B (it) |
| IT (1) | IT1106118B (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4294763A (en) * | 1980-03-05 | 1981-10-13 | University Of Rochester | Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof |
| DE3476752D1 (en) * | 1983-06-01 | 1989-03-23 | Ciba Geigy Ag | Process for the preparation of 2-arylbenzotriazoles |
| GB8424269D0 (en) * | 1984-09-26 | 1984-10-31 | Pharma Medica As | Isolation and purification of podophyllotoxin |
| EP0207124B1 (en) * | 1984-12-28 | 1991-10-09 | Conpharm Ab | Use of podophyllotoxin and derivatives thereof |
| US5011948A (en) * | 1985-04-12 | 1991-04-30 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| US4644072A (en) * | 1985-04-12 | 1987-02-17 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
| JPS6236371A (ja) * | 1985-07-24 | 1987-02-17 | Nichirei:Kk | 新規抗菌性物質およびその製法 |
| DE3530718A1 (de) * | 1985-08-28 | 1987-03-12 | Madaus & Co Dr | Methylendioxyphenanthren- und -stilbenderivate, verfahren zur herstellung derselben und arzneimittel, die diese enthalten |
| WO1990009788A1 (en) * | 1989-02-23 | 1990-09-07 | The University Of North Carolina At Chapel Hill | Etoposide analogues |
| US6051721A (en) * | 1997-10-02 | 2000-04-18 | The Board Of Regents Of The University Of Nebraska | Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis |
| WO2009100349A1 (en) * | 2008-02-09 | 2009-08-13 | The Trustees Of Columbia University In The City Of New York | Analogues of (-)-picropodophyllin, synthesis and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1088621A (en) * | 1963-12-12 | 1967-10-25 | Sandoz Ltd | Improvements in or relating to podophyllin derivatives |
| NL6613143A (it) * | 1965-09-21 | 1967-03-22 | ||
| US4059593A (en) * | 1975-12-22 | 1977-11-22 | University Of Rochester | Synthesis of steganacin and derivatives thereof |
-
1977
- 1977-08-25 US US05/827,487 patent/US4122092A/en not_active Expired - Lifetime
-
1978
- 1978-08-21 CA CA309,690A patent/CA1088952A/en not_active Expired
- 1978-08-23 GB GB7910536A patent/GB2017695B/en not_active Expired
- 1978-08-23 CH CH892778A patent/CH636870A5/de not_active IP Right Cessation
- 1978-08-23 GB GB7834349A patent/GB2003152B/en not_active Expired
- 1978-08-24 DE DE19782837033 patent/DE2837033A1/de active Granted
- 1978-08-24 IT IT50850/78A patent/IT1106118B/it active
- 1978-08-24 JP JP10236778A patent/JPS5495572A/ja active Granted
- 1978-08-25 ES ES472864A patent/ES472864A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2003152B (en) | 1982-01-20 |
| GB2003152A (en) | 1979-03-07 |
| JPS5495572A (en) | 1979-07-28 |
| ES472864A1 (es) | 1979-10-16 |
| GB2017695A (en) | 1979-10-10 |
| JPS6125033B2 (it) | 1986-06-13 |
| IT7850850A0 (it) | 1978-08-24 |
| CA1088952A (en) | 1980-11-04 |
| CH636870A5 (de) | 1983-06-30 |
| US4122092A (en) | 1978-10-24 |
| GB2017695B (en) | 1982-01-20 |
| DE2837033A1 (de) | 1979-03-22 |
| DE2837033C2 (it) | 1988-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1075280B (it) | Procedimento per la preparazione di derivati pirrolidinici | |
| IT1107675B (it) | Procedimento per la produzione di derivati ammidici in particolare acilanilidi sostituite e prodotto ottenuto | |
| IT1101613B (it) | Derivati di 2,6-diamminonebularine ad azione farmacolosica | |
| RO84425A (ro) | Procedeu pentru prepararea unor derivati de pleuromutilinglicozida | |
| IT1075564B (it) | Procedimento per la preparazione di derivati pirrolidinici | |
| IT1103464B (it) | Procedimento per la produzione di derivati benzimidazolici | |
| IT1156873B (it) | Procedimento per la produzione di derivati di 1/2/4-triazin-5-one | |
| IT1106118B (it) | Procedimento per la produzione di-picropodofillone e suoi derivati sostituiti mediante sintesi totale | |
| IT1156441B (it) | Procedimento per la preparazione di derivati di fenil ammidine | |
| IT7850879A0 (it) | Derivati 25-alchilcolesterolici erelativo procedimento di produzione | |
| IT7825800A0 (it) | Procedimento per la fabbricazione di p-idrossifenilglicina e suoi derivati | |
| IT1094003B (it) | Procedimento per produrre maitansinol e suoi derivati | |
| IT7848192A0 (it) | Procedimento per la produzione di derivati di 9-2-idrossietossimetilguanina e prodotto ottenuto | |
| IT7852072A0 (it) | Procedimenti per la produzione di derivati della fenossialcanolamina | |
| IT1104109B (it) | Procedimento per la produzione di derivati del 2,1,3-tiadiazin-4-on-2,2-biossido | |
| IT1092408B (it) | Procedimento per la produzione di derivati dell'indolina | |
| IT1105354B (it) | Procedimento per la produzione di antrachinoni sostituiti | |
| IT1110876B (it) | Procedimento per la preparazione di 1-idrossiaporfin derivati e prodotto ottenuto | |
| IT1096628B (it) | Derivati di 15-sostituita-w-pentanorprostaglandina | |
| IT1095477B (it) | Nuovi derivati del 9-fluoroprednisolone | |
| IT1044247B (it) | Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone | |
| IT1090572B (it) | Procedimento per la preparazione di derivati del chinazolinone | |
| IT1155770B (it) | Procedimento per la produzione di derivati di alchil-teofillina basicamente sostituiti | |
| IT7850286A0 (it) | Procedimento per la produzione di nuovi derivati di benzopirano | |
| IT1106081B (it) | Procedimento per la preparazione di derivati di 4-9-pregnano e prodotto ottenuto |