IT1106118B - PROCEDURE FOR THE PRODUCTION OF DI-PICROPODOPHYLLON AND ITS DERIVATIVES REPLACED BY TOTAL SYNTHESIS - Google Patents

PROCEDURE FOR THE PRODUCTION OF DI-PICROPODOPHYLLON AND ITS DERIVATIVES REPLACED BY TOTAL SYNTHESIS

Info

Publication number
IT1106118B
IT1106118B IT50850/78A IT5085078A IT1106118B IT 1106118 B IT1106118 B IT 1106118B IT 50850/78 A IT50850/78 A IT 50850/78A IT 5085078 A IT5085078 A IT 5085078A IT 1106118 B IT1106118 B IT 1106118B
Authority
IT
Italy
Prior art keywords
picropodophyllon
procedure
production
total synthesis
derivatives replaced
Prior art date
Application number
IT50850/78A
Other languages
Italian (it)
Other versions
IT7850850A0 (en
Original Assignee
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester filed Critical Univ Rochester
Publication of IT7850850A0 publication Critical patent/IT7850850A0/en
Application granted granted Critical
Publication of IT1106118B publication Critical patent/IT1106118B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT50850/78A 1977-08-25 1978-08-24 PROCEDURE FOR THE PRODUCTION OF DI-PICROPODOPHYLLON AND ITS DERIVATIVES REPLACED BY TOTAL SYNTHESIS IT1106118B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/827,487 US4122092A (en) 1977-08-25 1977-08-25 Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone

Publications (2)

Publication Number Publication Date
IT7850850A0 IT7850850A0 (en) 1978-08-24
IT1106118B true IT1106118B (en) 1985-11-11

Family

ID=25249348

Family Applications (1)

Application Number Title Priority Date Filing Date
IT50850/78A IT1106118B (en) 1977-08-25 1978-08-24 PROCEDURE FOR THE PRODUCTION OF DI-PICROPODOPHYLLON AND ITS DERIVATIVES REPLACED BY TOTAL SYNTHESIS

Country Status (8)

Country Link
US (1) US4122092A (en)
JP (1) JPS5495572A (en)
CA (1) CA1088952A (en)
CH (1) CH636870A5 (en)
DE (1) DE2837033A1 (en)
ES (1) ES472864A1 (en)
GB (2) GB2017695B (en)
IT (1) IT1106118B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
EP0130938B1 (en) * 1983-06-01 1989-02-15 Ciba-Geigy Ag Process for the preparation of 2-arylbenzotriazoles
GB8424269D0 (en) * 1984-09-26 1984-10-31 Pharma Medica As Isolation and purification of podophyllotoxin
HU201672B (en) * 1984-12-28 1990-12-28 Conpharm Ab Process for producing pharmaceutical compositions comprising podophyllotoxin
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6236371A (en) * 1985-07-24 1987-02-17 Nichirei:Kk Novel antimicrobial substance and production thereof
DE3530718A1 (en) * 1985-08-28 1987-03-12 Madaus & Co Dr METHYLENE DIOXYPHENANTHENE AND STYLENE DERIVATIVES, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THE SAME
AU632796B2 (en) * 1989-02-23 1993-01-14 University Of North Carolina At Chapel Hill, The Etoposide analogues
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
WO2009100349A1 (en) * 2008-02-09 2009-08-13 The Trustees Of Columbia University In The City Of New York Analogues of (-)-picropodophyllin, synthesis and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088621A (en) * 1963-12-12 1967-10-25 Sandoz Ltd Improvements in or relating to podophyllin derivatives
NL6613143A (en) * 1965-09-21 1967-03-22
US4059593A (en) * 1975-12-22 1977-11-22 University Of Rochester Synthesis of steganacin and derivatives thereof

Also Published As

Publication number Publication date
GB2017695A (en) 1979-10-10
US4122092A (en) 1978-10-24
JPS5495572A (en) 1979-07-28
GB2017695B (en) 1982-01-20
DE2837033A1 (en) 1979-03-22
CH636870A5 (en) 1983-06-30
GB2003152A (en) 1979-03-07
IT7850850A0 (en) 1978-08-24
CA1088952A (en) 1980-11-04
ES472864A1 (en) 1979-10-16
JPS6125033B2 (en) 1986-06-13
DE2837033C2 (en) 1988-04-21
GB2003152B (en) 1982-01-20

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