DE2803236C2 - Verfahren zur Herstellung von Cholesterin-Derivaten - Google Patents

Verfahren zur Herstellung von Cholesterin-Derivaten

Info

Publication number
DE2803236C2
DE2803236C2 DE2803236A DE2803236A DE2803236C2 DE 2803236 C2 DE2803236 C2 DE 2803236C2 DE 2803236 A DE2803236 A DE 2803236A DE 2803236 A DE2803236 A DE 2803236A DE 2803236 C2 DE2803236 C2 DE 2803236C2
Authority
DE
Germany
Prior art keywords
hydroxy
diborane
borohydride
epoxy
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2803236A
Other languages
German (de)
English (en)
Other versions
DE2803236A1 (de
Inventor
Robert Angelo Passaic N.J. Micheli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2803236A1 publication Critical patent/DE2803236A1/de
Application granted granted Critical
Publication of DE2803236C2 publication Critical patent/DE2803236C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE2803236A 1977-01-26 1978-01-25 Verfahren zur Herstellung von Cholesterin-Derivaten Expired DE2803236C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/762,604 US4098801A (en) 1977-01-26 1977-01-26 Synthesis of 1α-hydroxylated derivatives of cholesterol

Publications (2)

Publication Number Publication Date
DE2803236A1 DE2803236A1 (de) 1978-07-27
DE2803236C2 true DE2803236C2 (de) 1984-06-28

Family

ID=25065548

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2803236A Expired DE2803236C2 (de) 1977-01-26 1978-01-25 Verfahren zur Herstellung von Cholesterin-Derivaten

Country Status (9)

Country Link
US (1) US4098801A (OSRAM)
JP (1) JPS5392755A (OSRAM)
AT (1) AT357278B (OSRAM)
BE (1) BE863284A (OSRAM)
CH (1) CH629505A5 (OSRAM)
DE (1) DE2803236C2 (OSRAM)
FR (1) FR2378798A1 (OSRAM)
GB (1) GB1595165A (OSRAM)
NL (1) NL7800086A (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6039278B2 (ja) * 1977-05-23 1985-09-05 中外製薬株式会社 ステロイド誘導体
US4226787A (en) * 1978-07-26 1980-10-07 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4229358A (en) * 1978-07-26 1980-10-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901928A (en) * 1973-01-10 1975-08-26 Robert Henry Hesse 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US3887545A (en) * 1973-11-12 1975-06-03 Hoffmann La Roche Synthesis of 1{60 -hydroxylated cholesterol derivatives

Also Published As

Publication number Publication date
CH629505A5 (de) 1982-04-30
US4098801A (en) 1978-07-04
JPS5392755A (en) 1978-08-15
JPS5517038B2 (OSRAM) 1980-05-08
FR2378798B1 (OSRAM) 1982-07-09
GB1595165A (en) 1981-08-12
ATA55178A (de) 1979-11-15
AT357278B (de) 1980-06-25
DE2803236A1 (de) 1978-07-27
NL7800086A (nl) 1978-07-28
BE863284A (fr) 1978-07-25
FR2378798A1 (fr) 1978-08-25

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Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee