DE2741763A1 - Substituierte 6-phenyl-1,2,4-triazolo eckige klammer auf 4,3-b eckige klammer zu pyridazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel - Google Patents

Substituierte 6-phenyl-1,2,4-triazolo eckige klammer auf 4,3-b eckige klammer zu pyridazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Info

Publication number
DE2741763A1
DE2741763A1 DE19772741763 DE2741763A DE2741763A1 DE 2741763 A1 DE2741763 A1 DE 2741763A1 DE 19772741763 DE19772741763 DE 19772741763 DE 2741763 A DE2741763 A DE 2741763A DE 2741763 A1 DE2741763 A1 DE 2741763A1
Authority
DE
Germany
Prior art keywords
group
groups
atoms
methyl
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772741763
Other languages
German (de)
English (en)
Inventor
Jay Donald Albright
Jun George Rodger Allen
Jun John William Hanifin
Daniel Bryan Moran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/725,597 external-priority patent/US4230705A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE2741763A1 publication Critical patent/DE2741763A1/de
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19772741763 1976-09-22 1977-09-16 Substituierte 6-phenyl-1,2,4-triazolo eckige klammer auf 4,3-b eckige klammer zu pyridazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel Withdrawn DE2741763A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/725,597 US4230705A (en) 1976-09-22 1976-09-22 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
US73039576A 1976-10-07 1976-10-07
US73547576A 1976-10-26 1976-10-26

Publications (1)

Publication Number Publication Date
DE2741763A1 true DE2741763A1 (de) 1978-03-23

Family

ID=27419081

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772741763 Withdrawn DE2741763A1 (de) 1976-09-22 1977-09-16 Substituierte 6-phenyl-1,2,4-triazolo eckige klammer auf 4,3-b eckige klammer zu pyridazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Country Status (19)

Country Link
JP (1) JPS5340798A (cs)
AR (2) AR218036A1 (cs)
AT (1) AT360034B (cs)
AU (1) AU513760B2 (cs)
BG (1) BG29287A3 (cs)
CA (1) CA1080712A (cs)
DD (1) DD132586A5 (cs)
DE (1) DE2741763A1 (cs)
DK (1) DK417377A (cs)
ES (3) ES462543A1 (cs)
FI (1) FI772802A7 (cs)
FR (1) FR2442848A1 (cs)
GB (1) GB1589237A (cs)
GR (1) GR71699B (cs)
LU (1) LU78150A1 (cs)
NL (1) NL7710389A (cs)
NO (1) NO773245L (cs)
PT (1) PT67067B (cs)
RO (1) RO72226A (cs)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029130A1 (en) * 1979-10-29 1981-05-27 The Dow Chemical Company 3,6,7,8-Substituted-s-triazolo(4,3-b)-pyridazines, their preparation and compositions comprising them
FR2473522A1 (fr) * 1980-01-16 1981-07-17 Synthelabo Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
EP0094038A1 (de) * 1982-05-08 1983-11-16 Hoechst Aktiengesellschaft 3-Amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre Herstellung und ihre Verwendung
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
US4767765A (en) * 1985-10-31 1988-08-30 American Cyanamid Company N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
US4810705A (en) * 1984-03-03 1989-03-07 Sanofi Triazolo [3,4-b]pyridazines, process for their preparation and pharmaceutical compositions containing them
WO1999036423A1 (en) * 1998-01-14 1999-07-22 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037644A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037645A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037646A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6255305B1 (en) 1996-07-25 2001-07-03 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
US6291460B1 (en) 1998-01-22 2001-09-18 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
US6303605B1 (en) 1998-01-21 2001-10-16 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6319924B1 (en) 1998-01-21 2001-11-20 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6399608B1 (en) 1998-01-23 2002-06-04 Merck Sharp & Dohme Ltd. Combination of a GABA-A α 2/3 agonist and a selective serotonin reuptake inhibitor

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036711B1 (en) * 1980-03-22 1985-12-04 Fbc Limited Pesticidal heterocyclic compounds, processes for preparing them, compositions containing them, and their use
US4654343A (en) * 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
WO2005077953A1 (ja) * 2004-02-18 2005-08-25 Banyu Pharmaceutical Co., Ltd. 含窒素縮合へテロ芳香環誘導体
PT3548033T (pt) * 2016-11-28 2024-08-09 Praxis Prec Medicines Inc Compostos e respectivos métodos de utilização
CA3101324A1 (en) 2018-05-30 2019-12-05 Praxis Precision Medicines, Inc. Ion channel modulators
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
WO2021126779A1 (en) * 2019-12-18 2021-06-24 The Regents Of The University Of California Inhibitors of lin28 and methods of use thereof

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029130A1 (en) * 1979-10-29 1981-05-27 The Dow Chemical Company 3,6,7,8-Substituted-s-triazolo(4,3-b)-pyridazines, their preparation and compositions comprising them
FR2473522A1 (fr) * 1980-01-16 1981-07-17 Synthelabo Nouveaux derives substitues de dihydro-2,3 imidazo(1,2-b)pyridazines et les medicaments, utiles notamment comme antidepresseurs, qui en contiennent
EP0032856A1 (fr) * 1980-01-16 1981-07-29 Synthelabo Nouveaux dérivés de dihydro-2,3-imidazo(1,2-b)pyridazines, leur procédé de préparation et leur application en thérapeutique
EP0094038A1 (de) * 1982-05-08 1983-11-16 Hoechst Aktiengesellschaft 3-Amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre Herstellung und ihre Verwendung
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
US4810705A (en) * 1984-03-03 1989-03-07 Sanofi Triazolo [3,4-b]pyridazines, process for their preparation and pharmaceutical compositions containing them
US4767765A (en) * 1985-10-31 1988-08-30 American Cyanamid Company N-substituted-N-[3-(1,2,4-triazolo-[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
US6255305B1 (en) 1996-07-25 2001-07-03 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
EA002436B1 (ru) * 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Замещенные производные триазоло-пиридазина в качестве лигандов рецепторов гамк
WO1999036423A1 (en) * 1998-01-14 1999-07-22 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6303597B1 (en) 1998-01-14 2001-10-16 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037646A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
WO1999037645A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6303605B1 (en) 1998-01-21 2001-10-16 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6319924B1 (en) 1998-01-21 2001-11-20 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6355798B1 (en) 1998-01-21 2002-03-12 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
WO1999037644A1 (en) * 1998-01-21 1999-07-29 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
US6579875B1 (en) 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
US6699859B1 (en) 1998-01-21 2004-03-02 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6828322B2 (en) 1998-01-21 2004-12-07 Merck Sharp & Dohme Ltd. Triazolo-pyridazine derivatives as ligands for GABA receptors
US6291460B1 (en) 1998-01-22 2001-09-18 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
US6399608B1 (en) 1998-01-23 2002-06-04 Merck Sharp & Dohme Ltd. Combination of a GABA-A α 2/3 agonist and a selective serotonin reuptake inhibitor

Also Published As

Publication number Publication date
BG29287A3 (bg) 1980-10-15
GR71699B (cs) 1983-06-21
PT67067A (en) 1977-10-01
RO72226A (ro) 1982-09-09
AU513760B2 (en) 1980-12-18
AU2899577A (en) 1979-03-29
AR217886A1 (es) 1980-04-30
LU78150A1 (cs) 1978-01-23
CA1080712A (en) 1980-07-01
DD132586A5 (de) 1978-10-11
NO773245L (no) 1978-03-28
DK417377A (da) 1978-03-23
JPS5340798A (en) 1978-04-13
GB1589237A (en) 1981-05-07
ES477799A1 (es) 1980-04-01
FR2442848A1 (fr) 1980-06-27
ES462543A1 (es) 1979-06-16
PT67067B (en) 1979-02-19
ES477800A1 (es) 1979-10-16
FI772802A7 (fi) 1978-03-23
ATA677577A (de) 1980-05-15
AR218036A1 (es) 1980-05-15
AT360034B (de) 1980-12-10
NL7710389A (nl) 1978-03-28

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