DE2739443C2 - - Google Patents

Info

Publication number
DE2739443C2
DE2739443C2 DE2739443A DE2739443A DE2739443C2 DE 2739443 C2 DE2739443 C2 DE 2739443C2 DE 2739443 A DE2739443 A DE 2739443A DE 2739443 A DE2739443 A DE 2739443A DE 2739443 C2 DE2739443 C2 DE 2739443C2
Authority
DE
Germany
Prior art keywords
vlb
deacetyl
general formula
compounds
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2739443A
Other languages
German (de)
English (en)
Other versions
DE2739443A1 (de
Inventor
George Joseph Trafalgar Ind. Us Cullinan
Koert Indianapolis Ind. Us Gerzon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE2739443A1 publication Critical patent/DE2739443A1/de
Application granted granted Critical
Publication of DE2739443C2 publication Critical patent/DE2739443C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE19772739443 1976-09-08 1977-09-01 Dimere indol-dihydroindolcarboxamide, verfahren zu ihrer herstellung und ihre verwendung Granted DE2739443A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72165076A 1976-09-08 1976-09-08

Publications (2)

Publication Number Publication Date
DE2739443A1 DE2739443A1 (de) 1978-03-09
DE2739443C2 true DE2739443C2 (es) 1991-08-14

Family

ID=24898757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772739443 Granted DE2739443A1 (de) 1976-09-08 1977-09-01 Dimere indol-dihydroindolcarboxamide, verfahren zu ihrer herstellung und ihre verwendung

Country Status (27)

Country Link
JP (1) JPS5340799A (es)
AR (3) AR226411A1 (es)
AT (1) AT360513B (es)
AU (1) AU511055B2 (es)
BE (1) BE858451A (es)
CA (1) CA1082179A (es)
CH (1) CH631990A5 (es)
DD (1) DD133055A5 (es)
DE (1) DE2739443A1 (es)
DK (1) DK146822C (es)
ES (1) ES462229A1 (es)
FR (1) FR2364220A1 (es)
GB (1) GB1586709A (es)
GR (1) GR69783B (es)
HU (1) HU180722B (es)
IE (1) IE45558B1 (es)
IL (1) IL52731A0 (es)
MX (1) MX4740E (es)
NL (1) NL7709806A (es)
NZ (1) NZ184932A (es)
PH (1) PH14771A (es)
PL (1) PL104309B1 (es)
PT (1) PT66984B (es)
RO (3) RO77921A (es)
SE (1) SE434953B (es)
YU (1) YU209777A (es)
ZA (1) ZA774988B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE30561E (en) * 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
AR225153A1 (es) * 1978-10-10 1982-02-26 Lilly Co Eli Un procedimiento para la preparacion de sulfato de vindesina
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine

Also Published As

Publication number Publication date
ZA774988B (en) 1979-03-28
RO77922A (ro) 1981-12-25
ATA644277A (de) 1980-06-15
CH631990A5 (en) 1982-09-15
CA1082179A (en) 1980-07-22
PT66984B (en) 1979-02-13
PH14771A (en) 1981-12-09
FR2364220A1 (fr) 1978-04-07
JPS624398B2 (es) 1987-01-30
SE434953B (sv) 1984-08-27
NZ184932A (en) 1979-11-01
YU209777A (en) 1982-08-31
IE771700L (en) 1978-03-08
IE45558B1 (en) 1982-09-22
AU2803977A (en) 1979-02-22
BE858451A (fr) 1978-03-07
IL52731A0 (en) 1977-10-31
GR69783B (es) 1982-07-07
PL200607A1 (pl) 1978-05-22
HU180722B (en) 1983-04-29
RO77921A (ro) 1981-12-25
MX4740E (es) 1982-08-25
GB1586709A (en) 1981-03-25
PL104309B1 (pl) 1979-08-31
DE2739443A1 (de) 1978-03-09
FR2364220B1 (es) 1980-04-25
PT66984A (en) 1977-10-01
RO72474A (ro) 1982-05-10
ES462229A1 (es) 1978-07-16
AR231643A1 (es) 1985-01-31
JPS5340799A (en) 1978-04-13
NL7709806A (nl) 1978-03-10
AT360513B (de) 1981-01-12
DD133055A5 (de) 1978-11-29
DK398577A (da) 1978-03-09
SE7710059L (sv) 1978-03-09
AR230642A1 (es) 1984-05-31
DK146822C (da) 1984-06-25
AU511055B2 (en) 1980-07-24
AR226411A1 (es) 1982-07-15
DK146822B (da) 1984-01-16

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 800

8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee