DE2728643A1 - Benzazocine, verfahren zu ihrer herstellung und arzneipraeparate - Google Patents

Benzazocine, verfahren zu ihrer herstellung und arzneipraeparate

Info

Publication number
DE2728643A1
DE2728643A1 DE19772728643 DE2728643A DE2728643A1 DE 2728643 A1 DE2728643 A1 DE 2728643A1 DE 19772728643 DE19772728643 DE 19772728643 DE 2728643 A DE2728643 A DE 2728643A DE 2728643 A1 DE2728643 A1 DE 2728643A1
Authority
DE
Germany
Prior art keywords
hexahydro
benzazocine
methano
hydroxy
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772728643
Other languages
German (de)
English (en)
Inventor
Yugo Ikeda
Morio Kakimoto
Sadao Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE2728643A1 publication Critical patent/DE2728643A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DE19772728643 1976-06-24 1977-06-24 Benzazocine, verfahren zu ihrer herstellung und arzneipraeparate Withdrawn DE2728643A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51073789A JPS5919542B2 (ja) 1976-06-24 1976-06-24 ベンズアゾシン誘導体

Publications (1)

Publication Number Publication Date
DE2728643A1 true DE2728643A1 (de) 1978-01-05

Family

ID=13528299

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772728643 Withdrawn DE2728643A1 (de) 1976-06-24 1977-06-24 Benzazocine, verfahren zu ihrer herstellung und arzneipraeparate

Country Status (5)

Country Link
US (1) US4166174A (https=)
JP (1) JPS5919542B2 (https=)
DE (1) DE2728643A1 (https=)
FR (1) FR2355831A1 (https=)
GB (1) GB1563745A (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731366A (en) * 1986-08-05 1988-03-15 Harbor Branch Oceanographic Institution, Inc. Discorhabdin compositions and their methods of use
JPS6359848U (https=) * 1986-10-07 1988-04-21
JPH033554U (https=) * 1989-05-30 1991-01-14
TW200927115A (en) * 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5538239B2 (ja) * 2008-02-12 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639407A (en) * 1965-05-05 1972-02-01 Geigy Chem Corp Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines
US3449332A (en) * 1967-02-27 1969-06-10 Geigy Chem Corp Novel methanobenzazocines and processes
US3634433A (en) * 1967-06-07 1972-01-11 Sumitomo Chemical Co Process for producing 6 7-benzomorphane derivatives of amine type useful as analgesics
US3639410A (en) * 1968-07-26 1972-02-01 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro - 8 - substituted-6-alkyl-11-(h or a lkyl) - 26-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
US3631051A (en) * 1969-05-28 1971-12-28 Sumitomo Chemical Co Process for producing 2-substituted 6 7-benzomorphan derivatives
US3823149A (en) * 1970-06-04 1974-07-09 N Albertson 3a,4,5,9b-tetrahydro-3,5-ethanonaphth(2,1-d)oxazol-2(3h)-ones
US3793332A (en) * 1972-05-22 1974-02-19 Sumitomo Chemical Co 2-cyano alkylbenzomorphan derivatives and salts thereof
CA1010031A (en) * 1972-10-31 1977-05-10 Kentaro Tamaki 6,7-benzomorphan derivatives
JPS551257B2 (https=) * 1972-11-22 1980-01-12
US4022789A (en) * 1975-11-20 1977-05-10 Sterling Drug Inc. Dichlorocyclopropylmethyl-benzazocines

Also Published As

Publication number Publication date
US4166174A (en) 1979-08-28
FR2355831A1 (fr) 1978-01-20
JPS52156868A (en) 1977-12-27
JPS5919542B2 (ja) 1984-05-07
FR2355831B1 (https=) 1980-04-04
GB1563745A (en) 1980-03-26

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Legal Events

Date Code Title Description
OAM Search report available
OC Search report available
8139 Disposal/non-payment of the annual fee