GB1563745A - Methanobenzazocine derivatives and process for preparing the same - Google Patents

Methanobenzazocine derivatives and process for preparing the same Download PDF

Info

Publication number
GB1563745A
GB1563745A GB25326/77A GB2532677A GB1563745A GB 1563745 A GB1563745 A GB 1563745A GB 25326/77 A GB25326/77 A GB 25326/77A GB 2532677 A GB2532677 A GB 2532677A GB 1563745 A GB1563745 A GB 1563745A
Authority
GB
United Kingdom
Prior art keywords
hexahydro
methano
hydroxy
benzazocine
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25326/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of GB1563745A publication Critical patent/GB1563745A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
GB25326/77A 1976-06-24 1977-06-16 Methanobenzazocine derivatives and process for preparing the same Expired GB1563745A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51073789A JPS5919542B2 (ja) 1976-06-24 1976-06-24 ベンズアゾシン誘導体

Publications (1)

Publication Number Publication Date
GB1563745A true GB1563745A (en) 1980-03-26

Family

ID=13528299

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25326/77A Expired GB1563745A (en) 1976-06-24 1977-06-16 Methanobenzazocine derivatives and process for preparing the same

Country Status (5)

Country Link
US (1) US4166174A (https=)
JP (1) JPS5919542B2 (https=)
DE (1) DE2728643A1 (https=)
FR (1) FR2355831A1 (https=)
GB (1) GB1563745A (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731366A (en) * 1986-08-05 1988-03-15 Harbor Branch Oceanographic Institution, Inc. Discorhabdin compositions and their methods of use
JPS6359848U (https=) * 1986-10-07 1988-04-21
JPH033554U (https=) * 1989-05-30 1991-01-14
TW200927115A (en) * 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5538239B2 (ja) * 2008-02-12 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639407A (en) * 1965-05-05 1972-02-01 Geigy Chem Corp Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines
US3449332A (en) * 1967-02-27 1969-06-10 Geigy Chem Corp Novel methanobenzazocines and processes
US3634433A (en) * 1967-06-07 1972-01-11 Sumitomo Chemical Co Process for producing 6 7-benzomorphane derivatives of amine type useful as analgesics
US3639410A (en) * 1968-07-26 1972-02-01 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro - 8 - substituted-6-alkyl-11-(h or a lkyl) - 26-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
US3631051A (en) * 1969-05-28 1971-12-28 Sumitomo Chemical Co Process for producing 2-substituted 6 7-benzomorphan derivatives
US3823149A (en) * 1970-06-04 1974-07-09 N Albertson 3a,4,5,9b-tetrahydro-3,5-ethanonaphth(2,1-d)oxazol-2(3h)-ones
US3793332A (en) * 1972-05-22 1974-02-19 Sumitomo Chemical Co 2-cyano alkylbenzomorphan derivatives and salts thereof
CA1010031A (en) * 1972-10-31 1977-05-10 Kentaro Tamaki 6,7-benzomorphan derivatives
JPS551257B2 (https=) * 1972-11-22 1980-01-12
US4022789A (en) * 1975-11-20 1977-05-10 Sterling Drug Inc. Dichlorocyclopropylmethyl-benzazocines

Also Published As

Publication number Publication date
US4166174A (en) 1979-08-28
FR2355831A1 (fr) 1978-01-20
JPS52156868A (en) 1977-12-27
JPS5919542B2 (ja) 1984-05-07
FR2355831B1 (https=) 1980-04-04
DE2728643A1 (de) 1978-01-05

Similar Documents

Publication Publication Date Title
US20020038028A1 (en) 7-Hetero-bicyclo[2.2.1]-heptanes
JPS6134426B2 (https=)
EP0796849A1 (en) Novel polycyclic aminopyridine compounds as acetylcholinesterase inhibitors, preparation process and use thereof
Beckwith et al. The synthesis of indolizidine and quinolizidine ring systems by free radical cyclization of 4-aza-6-methoxycarbonyl-5-hexenyl radicals
GB1563745A (en) Methanobenzazocine derivatives and process for preparing the same
Bennasar et al. First total synthesis of the indole alkaloid ervitsine. A straightforward, biomimetic approach
DE69318920T2 (de) Ellipticinderivate mit Antitumorwirkung
EP0150474B1 (de) Verfahren zur Herstellung von 5,6-Dihydro-pyrrolo[2,1-a]isochinolinen
US4929622A (en) 2,6-Methanopyrrolo-3-benzazocines
DE69119323T2 (de) Fluoräthylcamptothecinderivate
US4362739A (en) Pyrrolo(2,3-d)carbazole derivatives, compositions and use
Craig et al. Curariform Activity and Chemical Structure. II. Synthesis in the Benzyltetrahydroisoquinoline Series1
US3839340A (en) Substituted 1,3,8-triazaspiro{8 4.5{9 decanes
SK127699A3 (en) 2,3-dihydrofuro[3,2-b]pyridin, preparation and application thereof in therapy
Bosch et al. Mercuric acetate cyclization of 4-(arylmethyl) piperidines; synthesis of indolo [2, 3-g] morphans (tetracyclic ring system of strychnos indole alkaloids) and 7, 8-benzomorphans
US3557122A (en) 5,6,7a,8,11,11a,12,12a-octahydroindolo (2,1-a)isoquinolin-9(10h)-ones
US3326923A (en) Cis-indolomorphinanones and process for their production
Compernolle et al. The synthesis of ester and ketone analogues of 1-deoxynojirimycin and castanospermine
EP0004960B1 (en) 9.9-dimethyl-6.7-benzomorphan derivatives, processes for their preparation and pharmaceutical compositions comprising them
Heydenreich et al. Synthesis and stereochemical studies of 1-and 2-phenyl-substituted 1, 3-oxazino [4, 3-a] isoquinoline derivatives
US2877226A (en) Novel quinolizine compounds and proc-
EP0001585B1 (de) Piperazino-pyrrolobenzodiazepine, Verfahren zu ihrer Herstellung sowie pharmazeutische Präparate enthaltend diese Verbindungen
US3839342A (en) Substituted 1,3,8-triazaspiro(4.5)decanes
AU683964B2 (en) Substituted aminoalkylaminopyridines
US20070066827A1 (en) Process for the preparation of aryl fused polycyclic lactams

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee