DE2715255C3 - Anthracyclinglykoside MA 144-M, und MA 144-M2 und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen - Google Patents

Anthracyclinglykoside MA 144-M, und MA 144-M2 und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE2715255C3
DE2715255C3 DE2715255A DE2715255A DE2715255C3 DE 2715255 C3 DE2715255 C3 DE 2715255C3 DE 2715255 A DE2715255 A DE 2715255A DE 2715255 A DE2715255 A DE 2715255A DE 2715255 C3 DE2715255 C3 DE 2715255C3
Authority
DE
Germany
Prior art keywords
brown
methanol
acid
salts
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2715255A
Other languages
German (de)
English (en)
Other versions
DE2715255A1 (de
DE2715255B2 (de
Inventor
Taiji Chigasaki Inui
Masaaki Ishizuka
Hiroshi Naganawa
Toshikazu Kamakura Oki
Norio Chigasaki Shibamoto
Tomio Takeuchi
Hamao Prof. Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of DE2715255A1 publication Critical patent/DE2715255A1/de
Publication of DE2715255B2 publication Critical patent/DE2715255B2/de
Application granted granted Critical
Publication of DE2715255C3 publication Critical patent/DE2715255C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/888—Streptomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE2715255A 1976-04-07 1977-04-05 Anthracyclinglykoside MA 144-M, und MA 144-M2 und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen Expired DE2715255C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3968876A JPS52136159A (en) 1976-04-07 1976-04-07 Anti/malignanttumor containing the same as active ingredients

Publications (3)

Publication Number Publication Date
DE2715255A1 DE2715255A1 (de) 1977-11-10
DE2715255B2 DE2715255B2 (de) 1979-01-04
DE2715255C3 true DE2715255C3 (de) 1979-08-30

Family

ID=12559990

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2715255A Expired DE2715255C3 (de) 1976-04-07 1977-04-05 Anthracyclinglykoside MA 144-M, und MA 144-M2 und deren Salze, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen

Country Status (11)

Country Link
US (2) US4144329A (US20090163788A1-20090625-C00002.png)
JP (1) JPS52136159A (US20090163788A1-20090625-C00002.png)
BE (1) BE853203A (US20090163788A1-20090625-C00002.png)
CA (1) CA1097238A (US20090163788A1-20090625-C00002.png)
DE (1) DE2715255C3 (US20090163788A1-20090625-C00002.png)
DK (1) DK146342C (US20090163788A1-20090625-C00002.png)
ES (3) ES475579A1 (US20090163788A1-20090625-C00002.png)
FR (1) FR2347381A1 (US20090163788A1-20090625-C00002.png)
GB (1) GB1563432A (US20090163788A1-20090625-C00002.png)
NL (1) NL168557C (US20090163788A1-20090625-C00002.png)
SE (1) SE436758B (US20090163788A1-20090625-C00002.png)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123608A (en) * 1977-07-18 1978-10-31 Bristol-Myers Company Antibiotic compound
ZA802929B (en) * 1979-05-22 1981-05-27 Hoffmann La Roche Novel tetracyclic compounds and process for the preparation thereof
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
DE3071391D1 (en) * 1979-09-07 1986-03-13 Sanraku Ocean Co 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
JPS5767518A (en) * 1980-09-17 1982-04-24 Yamasa Shoyu Co Ltd Radiosensitizing agent or agent for increasing effect of radiomimetic substance
CH648327A5 (de) * 1980-10-16 1985-03-15 Hoffmann La Roche Anthracycline.
CA1187434A (en) * 1981-08-11 1985-05-21 Akihiro Yoshimoto Anthracycline antibiotics and their preparation method
JPS6133194A (ja) * 1984-07-25 1986-02-17 Sanraku Inc 新規アントラサイクリン抗生物質
US20050208037A1 (en) * 2003-10-21 2005-09-22 Board Of Regents, The University Of Texas System Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
CN104644631A (zh) * 2015-01-31 2015-05-27 云南省第一人民医院 新乌头碱对k562细胞生物学特性的改变

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846130A (en) 1956-03-23 1960-08-24 Ciba Ltd New antibiotic and derivatives and salts thereof, preparations containing the same and process for the manufacture of these substances
US3864480A (en) * 1974-05-06 1975-02-04 Merck & Co Inc Cinerubin A and B As Antiparasitic Agents
JPS5134915B2 (US20090163788A1-20090625-C00002.png) * 1974-07-27 1976-09-29
JPS5323961A (en) * 1976-08-16 1978-03-06 Microbial Chem Res Found Antitumors

Also Published As

Publication number Publication date
DK146342C (da) 1984-04-09
US4219622A (en) 1980-08-26
US4144329A (en) 1979-03-13
JPS52136159A (en) 1977-11-14
ES475579A1 (es) 1978-08-01
DE2715255A1 (de) 1977-11-10
ES469423A1 (es) 1979-04-01
DE2715255B2 (de) 1979-01-04
SE7703760L (sv) 1977-10-08
ES469424A1 (es) 1979-04-01
NL7703753A (nl) 1977-10-11
GB1563432A (en) 1980-03-26
JPS5438100B2 (US20090163788A1-20090625-C00002.png) 1979-11-19
CA1097238A (en) 1981-03-10
SE436758B (sv) 1985-01-21
FR2347381B1 (US20090163788A1-20090625-C00002.png) 1980-10-17
NL168557C (nl) 1982-04-16
DK146342B (da) 1983-09-12
FR2347381A1 (fr) 1977-11-04
DK152977A (da) 1977-10-08
BE853203A (fr) 1977-08-01

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Legal Events

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C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee