DE2714442A1 - Neue benzazepine, deren salze, herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Neue benzazepine, deren salze, herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE2714442A1 DE2714442A1 DE19772714442 DE2714442A DE2714442A1 DE 2714442 A1 DE2714442 A1 DE 2714442A1 DE 19772714442 DE19772714442 DE 19772714442 DE 2714442 A DE2714442 A DE 2714442A DE 2714442 A1 DE2714442 A1 DE 2714442A1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- product
- tetrahydro
- benzazepine
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
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- 238000004519 manufacturing process Methods 0.000 title description 9
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 15
- 235000019253 formic acid Nutrition 0.000 claims description 15
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 10
- 150000008038 benzoazepines Chemical class 0.000 claims description 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
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- 235000005985 organic acids Nutrition 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims description 6
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 229940087646 methanolamine Drugs 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- WRQIUHICDOFSGH-UHFFFAOYSA-N n-methyl-2,3,4,5-tetrahydro-1h-1-benzazepin-3-amine Chemical compound N1CC(NC)CCC2=CC=CC=C21 WRQIUHICDOFSGH-UHFFFAOYSA-N 0.000 description 1
- 208000025319 neurotic depression Diseases 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000002295 serotoninergic effect Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7609333A FR2358151A1 (fr) | 1976-03-31 | 1976-03-31 | Nouvelles benzazepines et leurs sels, procede de preparation et application a titre de medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2714442A1 true DE2714442A1 (de) | 1977-10-13 |
Family
ID=9171207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772714442 Pending DE2714442A1 (de) | 1976-03-31 | 1977-03-31 | Neue benzazepine, deren salze, herstellungsverfahren und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4100278A (enExample) |
| JP (1) | JPS52122385A (enExample) |
| AT (1) | AT356112B (enExample) |
| BE (1) | BE853048A (enExample) |
| CA (1) | CA1081222A (enExample) |
| DE (1) | DE2714442A1 (enExample) |
| DK (1) | DK139677A (enExample) |
| FR (1) | FR2358151A1 (enExample) |
| GB (1) | GB1525351A (enExample) |
| NL (1) | NL7703504A (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0555183A1 (de) * | 1992-02-07 | 1993-08-11 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
| TW200510324A (en) * | 2003-08-11 | 2005-03-16 | Lilly Co Eli | 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist |
| FR2867187B1 (fr) * | 2004-03-02 | 2007-10-12 | Centre Nat Rech Scient | Procede utile pour la preparation de benzazepines et derives de celles-ci. |
| CL2008000838A1 (es) * | 2007-03-23 | 2008-10-10 | Neuraxon Inc | Compuestos derivados de quinolina y tetrahidroquinolina, con actividad inhibidora nos; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un dolor de cabeza tal como migrana, dolor cronico, desordenes del sistema nervios |
| DE102007028483A1 (de) * | 2007-06-21 | 2008-12-24 | Robert Bosch Gmbh | Sensoranordnung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1084287A (enExample) * | 1964-11-09 | |||
| FR1472930A (fr) * | 1965-04-02 | 1967-03-17 | Alphachimie | Nouveaux dérivés de la 2, 3, 4, 5-tétrahydro-(1eta)-2-benzazépine et leurs procédés de fabrication |
-
1976
- 1976-03-31 FR FR7609333A patent/FR2358151A1/fr active Granted
-
1977
- 1977-03-30 CA CA275,119A patent/CA1081222A/fr not_active Expired
- 1977-03-30 DK DK139677A patent/DK139677A/da not_active IP Right Cessation
- 1977-03-30 US US05/782,747 patent/US4100278A/en not_active Expired - Lifetime
- 1977-03-30 BE BE176262A patent/BE853048A/xx unknown
- 1977-03-31 AT AT225277A patent/AT356112B/de not_active IP Right Cessation
- 1977-03-31 JP JP3552377A patent/JPS52122385A/ja active Pending
- 1977-03-31 NL NL7703504A patent/NL7703504A/xx not_active Application Discontinuation
- 1977-03-31 DE DE19772714442 patent/DE2714442A1/de active Pending
- 1977-03-31 GB GB13537/77A patent/GB1525351A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4410807A (en) * | 1982-03-26 | 1983-10-18 | Kay Industries, Inc. | Regulating device for polyphase electrical circuits |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
Also Published As
| Publication number | Publication date |
|---|---|
| AT356112B (de) | 1980-04-10 |
| FR2358151A1 (fr) | 1978-02-10 |
| ATA225277A (de) | 1979-09-15 |
| CA1081222A (fr) | 1980-07-08 |
| BE853048A (fr) | 1977-09-30 |
| DK139677A (da) | 1977-10-01 |
| GB1525351A (en) | 1978-09-20 |
| JPS52122385A (en) | 1977-10-14 |
| NL7703504A (nl) | 1977-10-04 |
| US4100278A (en) | 1978-07-11 |
| FR2358151B1 (enExample) | 1978-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |