DE2652680A1 - O-, n- und carboxylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel - Google Patents

O-, n- und carboxylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel

Info

Publication number
DE2652680A1
DE2652680A1 DE19762652680 DE2652680A DE2652680A1 DE 2652680 A1 DE2652680 A1 DE 2652680A1 DE 19762652680 DE19762652680 DE 19762652680 DE 2652680 A DE2652680 A DE 2652680A DE 2652680 A1 DE2652680 A1 DE 2652680A1
Authority
DE
Germany
Prior art keywords
radical
carbon atoms
methyl
atom
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19762652680
Other languages
German (de)
English (en)
Inventor
Burton Grant Christensen
John Hannah
William Joseph Leanza
Ronald William Ratcliffe
David Houng-Min Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2652680A1 publication Critical patent/DE2652680A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19762652680 1975-11-21 1976-11-19 O-, n- und carboxylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel Withdrawn DE2652680A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63429475A 1975-11-21 1975-11-21

Publications (1)

Publication Number Publication Date
DE2652680A1 true DE2652680A1 (de) 1977-06-02

Family

ID=24543209

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762652680 Withdrawn DE2652680A1 (de) 1975-11-21 1976-11-19 O-, n- und carboxylderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel

Country Status (8)

Country Link
JP (1) JPS5277082A (enExample)
CH (1) CH633554A5 (enExample)
DE (1) DE2652680A1 (enExample)
DK (1) DK523376A (enExample)
FR (1) FR2332015A1 (enExample)
GB (1) GB1570987A (enExample)
NL (1) NL7612942A (enExample)
SE (1) SE7612961L (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007152A1 (en) * 1978-04-28 1980-01-23 Beecham Group Plc Beta-lactam antibiotics, preparation and use
EP0008888A1 (en) * 1978-08-23 1980-03-19 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
EP0044142A1 (en) * 1980-07-03 1982-01-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1531141A (en) * 1976-08-17 1978-11-01 Beecham Group Ltd Beta-lactam antibiotics
NL7712092A (nl) * 1976-11-17 1978-05-19 Merck & Co Inc Werkwijze ter bereiding van een nieuw antibiotisch middel.
DE2963717D1 (en) * 1978-05-06 1982-11-04 Beecham Group Plc Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552638A1 (de) * 1974-11-25 1976-05-26 Merck & Co Inc Antibiotica

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552638A1 (de) * 1974-11-25 1976-05-26 Merck & Co Inc Antibiotica

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007152A1 (en) * 1978-04-28 1980-01-23 Beecham Group Plc Beta-lactam antibiotics, preparation and use
EP0008888A1 (en) * 1978-08-23 1980-03-19 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
EP0044142A1 (en) * 1980-07-03 1982-01-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics

Also Published As

Publication number Publication date
DK523376A (da) 1977-05-22
JPS5277082A (en) 1977-06-29
GB1570987A (en) 1980-07-09
FR2332015B1 (enExample) 1978-11-10
SE7612961L (sv) 1977-05-22
JPS61345B2 (enExample) 1986-01-08
FR2332015A1 (fr) 1977-06-17
CH633554A5 (en) 1982-12-15
NL7612942A (nl) 1977-05-24

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee