GB1531141A - Beta-lactam antibiotics - Google Patents

Beta-lactam antibiotics

Info

Publication number
GB1531141A
GB1531141A GB34106/76A GB3410676A GB1531141A GB 1531141 A GB1531141 A GB 1531141A GB 34106/76 A GB34106/76 A GB 34106/76A GB 3410676 A GB3410676 A GB 3410676A GB 1531141 A GB1531141 A GB 1531141A
Authority
GB
United Kingdom
Prior art keywords
beta
lactam antibiotics
gram
penicillins
lactamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34106/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB34106/76A priority Critical patent/GB1531141A/en
Priority to IL52638A priority patent/IL52638A/en
Priority to NZ184808A priority patent/NZ184808A/en
Priority to PT66882A priority patent/PT66882B/en
Priority to ZA00774703A priority patent/ZA774703B/en
Priority to SE7709071A priority patent/SE7709071L/en
Priority to FI772432A priority patent/FI772432A/en
Priority to FR7724894A priority patent/FR2362142A1/en
Priority to DE19772736482 priority patent/DE2736482A1/en
Priority to BE180166A priority patent/BE857781A/en
Priority to CH996577A priority patent/CH639664A5/en
Priority to NL7709007A priority patent/NL7709007A/en
Priority to DK364177A priority patent/DK364177A/en
Priority to CA284,777A priority patent/CA1104139A/en
Priority to IE1713/77A priority patent/IE45559B1/en
Priority to AT592177A priority patent/AT351678B/en
Priority to ES461691A priority patent/ES461691A1/en
Priority to AU27986/77A priority patent/AU518375B2/en
Priority to JP9909877A priority patent/JPS5323995A/en
Publication of GB1531141A publication Critical patent/GB1531141A/en
Priority to FR7831817A priority patent/FR2405260A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Salts of the compounds of the formula II are obtained by esterifying a salt of a corresponding 2-carboxylic acid. The products are antibacterially active and can increase the activity of penicillins and cephalosporins against ss-lactamase-producing strains of various Gram-positive and Gram-negative bacteria. <IMAGE>
GB34106/76A 1976-08-17 1976-08-17 Beta-lactam antibiotics Expired GB1531141A (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
GB34106/76A GB1531141A (en) 1976-08-17 1976-08-17 Beta-lactam antibiotics
IL52638A IL52638A (en) 1976-08-17 1977-08-02 Clivanic acid derivatives,their preparation and pharmaceutical compositions containing them
NZ184808A NZ184808A (en) 1976-08-17 1977-08-02 Heterocyclic compounds and pharmaceutical compositions
PT66882A PT66882B (en) 1976-08-17 1977-08-03 PROCESS FOR THE PREPARATION OF ANTI-BACTERIAL COMPOUNDS
ZA00774703A ZA774703B (en) 1976-08-17 1977-08-04 Antibacterial compounds
SE7709071A SE7709071L (en) 1976-08-17 1977-08-10 OLIVANIC ACID ESTERS
BE180166A BE857781A (en) 1976-08-17 1977-08-12 BETA-LACTAM ANTIBACTERIAL COMPOUNDS
FR7724894A FR2362142A1 (en) 1976-08-17 1977-08-12 BETA-LACTAM ANTIBACTERIAL COMPOUNDS
DE19772736482 DE2736482A1 (en) 1976-08-17 1977-08-12 SALTS OF DERIVATIVES OF 6- (1-SULFATO-AETHYL) -7-OXO-1-AZABICYCLO SQUARE CLAMP ON 3.2.0 SQUARE CLAMP ON HEPT-2-EN-2-CARBONIC ACID ESTERS, METHOD FOR THE PRODUCTION THEREOF AND THEIR SALTS INCLUDE
FI772432A FI772432A (en) 1976-08-17 1977-08-12 ANTIBAKTERIELLA FOERENINGAR
CH996577A CH639664A5 (en) 1976-08-17 1977-08-15 Process for the preparation of salts of 6-(1-sulphatoethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxyic acid esters
CA284,777A CA1104139A (en) 1976-08-17 1977-08-16 Antibacterial compounds
DK364177A DK364177A (en) 1976-08-17 1977-08-16 PROCEDURE FOR THE PREPARATION OF ANTIBACTERIAL ACTIVE COMPOUNDS
NL7709007A NL7709007A (en) 1976-08-17 1977-08-16 METHOD FOR PREPARING NEW COMPOUNDS WITH ANTI-BACTERIAL ACTION, AND FORMED PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
IE1713/77A IE45559B1 (en) 1976-08-17 1977-08-16 Lactam antibiotics
AT592177A AT351678B (en) 1976-08-17 1977-08-16 METHOD FOR PRODUCING NEW ESTERS OF SALTS OF 6- (1-SULFATOAETHYL) -7-OXO-1- AZABICYCLO (3,2,0) HEPT-2-EN-2-CARBONIC ACID
ES461691A ES461691A1 (en) 1976-08-17 1977-08-17 Beta-lactam antibiotics
AU27986/77A AU518375B2 (en) 1976-08-17 1977-08-17 Ester of mm4550, mm13902 and mm17880
JP9909877A JPS5323995A (en) 1976-08-17 1977-08-17 Antiibacterial compound
FR7831817A FR2405260A1 (en) 1976-08-17 1978-11-10 ANTI-BACTERIAL COMPOUNDS WITH BETA-LACTAM CYCLE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34106/76A GB1531141A (en) 1976-08-17 1976-08-17 Beta-lactam antibiotics

Publications (1)

Publication Number Publication Date
GB1531141A true GB1531141A (en) 1978-11-01

Family

ID=10361448

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34106/76A Expired GB1531141A (en) 1976-08-17 1976-08-17 Beta-lactam antibiotics

Country Status (19)

Country Link
JP (1) JPS5323995A (en)
AT (1) AT351678B (en)
AU (1) AU518375B2 (en)
BE (1) BE857781A (en)
CA (1) CA1104139A (en)
CH (1) CH639664A5 (en)
DE (1) DE2736482A1 (en)
DK (1) DK364177A (en)
ES (1) ES461691A1 (en)
FI (1) FI772432A (en)
FR (2) FR2362142A1 (en)
GB (1) GB1531141A (en)
IE (1) IE45559B1 (en)
IL (1) IL52638A (en)
NL (1) NL7709007A (en)
NZ (1) NZ184808A (en)
PT (1) PT66882B (en)
SE (1) SE7709071L (en)
ZA (1) ZA774703B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044142A1 (en) * 1980-07-03 1982-01-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics
EP0057565A1 (en) * 1981-02-04 1982-08-11 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
US4530791A (en) * 1979-04-16 1985-07-23 Kowa Co., Ltd. β-Lactam antibiotics

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002564B1 (en) * 1977-11-12 1984-06-20 Beecham Group Plc Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates
EP0004132A1 (en) * 1978-03-04 1979-09-19 Beecham Group Plc Esters of beta-lactam antibiotics, a process for their preparation pharmaceutical compositions containing them and the compounds for use as antibacterial agents
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
DE2963580D1 (en) * 1978-08-02 1982-10-21 Beecham Group Plc Beta-lactam antibacterial agents, a process for their preparation and pharmaceutical compositions containing them
DE3070269D1 (en) * 1979-08-10 1985-04-18 Beecham Group Plc Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH633554A5 (en) * 1975-11-21 1982-12-15 Merck & Co Inc Process for the preparation of novel thienamycin derivatives.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4530791A (en) * 1979-04-16 1985-07-23 Kowa Co., Ltd. β-Lactam antibiotics
EP0044142A1 (en) * 1980-07-03 1982-01-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics
EP0057565A1 (en) * 1981-02-04 1982-08-11 Beecham Group Plc Beta-lactam antibiotics, their preparation and use

Also Published As

Publication number Publication date
JPS5323995A (en) 1978-03-06
FR2405260B1 (en) 1980-10-31
CH639664A5 (en) 1983-11-30
FI772432A (en) 1978-02-18
CA1104139A (en) 1981-06-30
AT351678B (en) 1979-08-10
BE857781A (en) 1978-02-13
DK364177A (en) 1978-02-18
AU518375B2 (en) 1981-10-01
DE2736482A1 (en) 1978-02-23
ES461691A1 (en) 1978-06-01
FR2362142B1 (en) 1981-11-06
PT66882B (en) 1979-01-24
PT66882A (en) 1977-09-01
SE7709071A0 (en) 1978-02-17
SE7709071L (en) 1978-02-17
IE45559L (en) 1978-02-17
NL7709007A (en) 1978-02-21
IE45559B1 (en) 1982-09-22
FR2405260A1 (en) 1979-05-04
AU2798677A (en) 1979-02-22
ZA774703B (en) 1978-06-28
IL52638A0 (en) 1977-10-31
IL52638A (en) 1980-12-31
FR2362142A1 (en) 1978-03-17
ATA592177A (en) 1979-01-15
NZ184808A (en) 1980-04-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee