FR2424280A1 - Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs. - Google Patents

Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs.

Info

Publication number
FR2424280A1
FR2424280A1 FR7812401A FR7812401A FR2424280A1 FR 2424280 A1 FR2424280 A1 FR 2424280A1 FR 7812401 A FR7812401 A FR 7812401A FR 7812401 A FR7812401 A FR 7812401A FR 2424280 A1 FR2424280 A1 FR 2424280A1
Authority
FR
France
Prior art keywords
tetrazolo
cpds
cephalosporin
reacting
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7812401A
Other languages
French (fr)
Other versions
FR2424280B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Cusi SA
Original Assignee
Laboratorios Cusi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Cusi SA filed Critical Laboratorios Cusi SA
Priority to FR7812401A priority Critical patent/FR2424280A1/en
Publication of FR2424280A1 publication Critical patent/FR2424280A1/en
Application granted granted Critical
Publication of FR2424280B1 publication Critical patent/FR2424280B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Abstract

Cephalosporins of formula (I) and their non-toxic salts are new. In (I), R is H, alkyl; X is H, alkyl, halogen, OH; z is H, OCH3. (I) are antibacterials active against both Gram-positive and Gram-negative organisms. Specific (I) include that in which R is methyl and X and Z are both H. In an example, this is prepd. by reacting 2-(5-methyl-1,3,4-thiadiazol-2-ylthio)acetic acid with pivaloyl chloride in the presence of triethylamine, reacting the product with 7-aminocephalosporanic acid in the presence of triethylamine, and reacting the resulting 7-acylaminocephalosporanic acid with tetrazolo/4,5-b/pyridazine-6-thiol.
FR7812401A 1978-04-26 1978-04-26 Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs. Granted FR2424280A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7812401A FR2424280A1 (en) 1978-04-26 1978-04-26 Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7812401A FR2424280A1 (en) 1978-04-26 1978-04-26 Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs.

Publications (2)

Publication Number Publication Date
FR2424280A1 true FR2424280A1 (en) 1979-11-23
FR2424280B1 FR2424280B1 (en) 1981-07-03

Family

ID=9207622

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812401A Granted FR2424280A1 (en) 1978-04-26 1978-04-26 Antibacterial tetrazolo-pyridazinyl:thio-cephalosporin cpds. - prepd. e.g. by reacting cephalosporin-C cpds. with tetrazolo-(4,5-b)-pyridazine-6-thiol derivs.

Country Status (1)

Country Link
FR (1) FR2424280A1 (en)

Also Published As

Publication number Publication date
FR2424280B1 (en) 1981-07-03

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