JPS5555149A - Dipeptide-type cephem derivative - Google Patents

Dipeptide-type cephem derivative

Info

Publication number
JPS5555149A
JPS5555149A JP12814378A JP12814378A JPS5555149A JP S5555149 A JPS5555149 A JP S5555149A JP 12814378 A JP12814378 A JP 12814378A JP 12814378 A JP12814378 A JP 12814378A JP S5555149 A JPS5555149 A JP S5555149A
Authority
JP
Japan
Prior art keywords
lower alkyl
dipeptide
formula
alkyl group
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12814378A
Other languages
Japanese (ja)
Other versions
JPS6132320B2 (en
Inventor
Minoru Yoshikawa
Makoto Sato
Yasuaki Osada
Shigetake Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP12814378A priority Critical patent/JPS5555149A/en
Publication of JPS5555149A publication Critical patent/JPS5555149A/en
Publication of JPS6132320B2 publication Critical patent/JPS6132320B2/ja
Granted legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NEW MATERIAL:A dipeptide-type cephem derivative of formula I: (R1 is H, lower alkyl group, etc.; R2 is H, lower alkyl group, etc.; R3 is amino or lower alkyl substituent on the thiazole ring at the 2- or 5-position; R4 is five-membered ring having 2W4 hetero atoms which may be substituted by a lower alkyl group), or its salt.
EXAMPLE: 7β- [2- (2-Aminopropionamido) -2- (2-aminothiazol-4-yl) -actamido] -3- (1-methyl-1H-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylic acid.
USE: Antibacterials having a great antibacterial activity against Gram-negative and Gram-positive bacteria, particularly Gram-negative bacilli.
PROCESS: A dipeptide or amino acid is neacted with pivaloyl chloride in a solvent, e.g. THF, to give a mixed acid anhydride, which is reacted with a compound of formula I. The protecting proup is eliminated to form the title compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP12814378A 1978-10-18 1978-10-18 Dipeptide-type cephem derivative Granted JPS5555149A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12814378A JPS5555149A (en) 1978-10-18 1978-10-18 Dipeptide-type cephem derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12814378A JPS5555149A (en) 1978-10-18 1978-10-18 Dipeptide-type cephem derivative

Publications (2)

Publication Number Publication Date
JPS5555149A true JPS5555149A (en) 1980-04-22
JPS6132320B2 JPS6132320B2 (en) 1986-07-25

Family

ID=14977449

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12814378A Granted JPS5555149A (en) 1978-10-18 1978-10-18 Dipeptide-type cephem derivative

Country Status (1)

Country Link
JP (1) JPS5555149A (en)

Also Published As

Publication number Publication date
JPS6132320B2 (en) 1986-07-25

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