JPS57156496A - Preparation of cephalosporin derivative - Google Patents

Preparation of cephalosporin derivative

Info

Publication number
JPS57156496A
JPS57156496A JP56175388A JP17538881A JPS57156496A JP S57156496 A JPS57156496 A JP S57156496A JP 56175388 A JP56175388 A JP 56175388A JP 17538881 A JP17538881 A JP 17538881A JP S57156496 A JPS57156496 A JP S57156496A
Authority
JP
Japan
Prior art keywords
compound
added
formula
ethoxycarbonyloxyethyl
aminothiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56175388A
Other languages
Japanese (ja)
Inventor
Senji Kakeya
Kazuhiko Kitao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyoto Pharmaceutical Industries Ltd
Original Assignee
Kyoto Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Industries Ltd filed Critical Kyoto Pharmaceutical Industries Ltd
Priority to JP56175388A priority Critical patent/JPS57156496A/en
Priority to AU81661/82A priority patent/AU8166182A/en
Priority to GR67640A priority patent/GR76477B/el
Priority to EP82102243A priority patent/EP0061162A3/en
Priority to IL65297A priority patent/IL65297A0/en
Priority to DK124682A priority patent/DK124682A/en
Priority to FI820999A priority patent/FI820999L/en
Priority to AR288824A priority patent/AR231293A1/en
Priority to ES510626A priority patent/ES510626A0/en
Priority to NO820935A priority patent/NO820935L/en
Publication of JPS57156496A publication Critical patent/JPS57156496A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

NEW MATERIAL:A compound (salt) of formulaI(R1 is lower alkyl; R2 is H or lower alkyl; R3 is alkyl).
EXAMPLE: 1'-Ethoxycarbonyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer).
USE: A remedy for microbism used in the oral adhministration against Gram- positive, Gram-negative bacteria, etc.
PROCESS: A compound of formula II, preferably having the amino group protected by a protecting group, e.g. 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetic acid, is added to an inert solvent, e.g. 2.2% phosphorus pentachloride.methylene dichloride solution, at -20W-15°C. Triethylamine is then added thereto, and a compound of formula III, e.g. 1'-ethoxycarbonyloxyethyl-7-aminocephem-4-carboxylate, is added thereto and reacted with the compound of formula II.
COPYRIGHT: (C)1982,JPO&Japio
JP56175388A 1981-03-23 1981-10-30 Preparation of cephalosporin derivative Pending JPS57156496A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP56175388A JPS57156496A (en) 1981-10-30 1981-10-30 Preparation of cephalosporin derivative
AU81661/82A AU8166182A (en) 1981-03-23 1982-03-18 Cephalosporin derivatives
GR67640A GR76477B (en) 1981-03-23 1982-03-18
EP82102243A EP0061162A3 (en) 1981-03-23 1982-03-19 Cephalosporin derivatives, pharmaceutical compositions containing the same and production thereof
IL65297A IL65297A0 (en) 1981-03-23 1982-03-19 Cephalosporin derivatives,pharmaceutical compositions containing the same and production thereof
DK124682A DK124682A (en) 1981-03-23 1982-03-19 PROCEDURE FOR PREPARING CEPHALOSPORIN DERIVATIVES OR ACID ADDITION SALTS
FI820999A FI820999L (en) 1981-03-23 1982-03-22 PROCEDURE FOR THE FRAMEWORK OF THE PHARMACEUTICAL SYSTEM
AR288824A AR231293A1 (en) 1981-03-23 1982-03-22 PROCEDURE FOR PREPARING 7-2-AMINOTIAZOL-4-II-ALCOXI-IMINOACETAMIDO-3-CEFEM-4-CARBOXILATO OF 1-ETOXICARBONILOXI-ETILO AND ITS SALTS
ES510626A ES510626A0 (en) 1981-03-23 1982-03-22 "A METHOD OF PRODUCING CEPHALOSPORIN DERIVATIVES".
NO820935A NO820935L (en) 1981-03-23 1982-03-22 CEPHALOSPORIN DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56175388A JPS57156496A (en) 1981-10-30 1981-10-30 Preparation of cephalosporin derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP4271881A Division JPS57156495A (en) 1981-03-23 1981-03-23 Cephalosporin derivative and remedy for microbism used in oral administration

Publications (1)

Publication Number Publication Date
JPS57156496A true JPS57156496A (en) 1982-09-27

Family

ID=15995229

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56175388A Pending JPS57156496A (en) 1981-03-23 1981-10-30 Preparation of cephalosporin derivative

Country Status (1)

Country Link
JP (1) JPS57156496A (en)

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