JPS5492982A - Dipeptide-type cephem derivative - Google Patents

Dipeptide-type cephem derivative

Info

Publication number
JPS5492982A
JPS5492982A JP15901077A JP15901077A JPS5492982A JP S5492982 A JPS5492982 A JP S5492982A JP 15901077 A JP15901077 A JP 15901077A JP 15901077 A JP15901077 A JP 15901077A JP S5492982 A JPS5492982 A JP S5492982A
Authority
JP
Japan
Prior art keywords
formula
group
dipeptide
compound
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15901077A
Other languages
Japanese (ja)
Other versions
JPS6339599B2 (en
Inventor
Minoru Furukawa
Yasuaki Osada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP15901077A priority Critical patent/JPS5492982A/en
Publication of JPS5492982A publication Critical patent/JPS5492982A/en
Publication of JPS6339599B2 publication Critical patent/JPS6339599B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A dipeptide-type cephem derivative of formula I: [R is phenyl, thiazole group, etc.; R is chain amino acid residue which may have thienyl group bonded to the α-carbon atom; R3 is H,-S-Hetero(Hetero is five-membered ring having 2W4 0, S, or N atoms)].
EXAMPLE: 7β-[D-2-(D-2-Aminopropionamide)-2-phenyl acetamide]-3-{[5-methyl- 1,3,4-thiadiazole-2-yl)thio]methyl}-3cephem-4-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria (particularly bacilli).
PROCESS: A mixed acid anhydride of a dipeptide of formula II: (Y is H or amino group; R5 is phenyl group, thiazole group, etc.) is reacted with a compound of formula III. to form a compound of formula IV, whose protective group is removed with a mixed acid of hydrochloric and acetic acids to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP15901077A 1977-12-28 1977-12-28 Dipeptide-type cephem derivative Granted JPS5492982A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15901077A JPS5492982A (en) 1977-12-28 1977-12-28 Dipeptide-type cephem derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15901077A JPS5492982A (en) 1977-12-28 1977-12-28 Dipeptide-type cephem derivative

Publications (2)

Publication Number Publication Date
JPS5492982A true JPS5492982A (en) 1979-07-23
JPS6339599B2 JPS6339599B2 (en) 1988-08-05

Family

ID=15684262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15901077A Granted JPS5492982A (en) 1977-12-28 1977-12-28 Dipeptide-type cephem derivative

Country Status (1)

Country Link
JP (1) JPS5492982A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118789A (en) * 1982-12-27 1984-07-09 Shionogi & Co Ltd Oxacephem derivative, its preparation and use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082085A (en) * 1973-09-13 1975-07-03
DE2724073A1 (en) * 1976-06-03 1977-12-22 Fujisawa Pharmaceutical Co 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBONIC ACIDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5082085A (en) * 1973-09-13 1975-07-03
DE2724073A1 (en) * 1976-06-03 1977-12-22 Fujisawa Pharmaceutical Co 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBONIC ACIDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118789A (en) * 1982-12-27 1984-07-09 Shionogi & Co Ltd Oxacephem derivative, its preparation and use

Also Published As

Publication number Publication date
JPS6339599B2 (en) 1988-08-05

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