DE2640599A1 - Verfahren zur herstellung von 1,4- benzodiazepinen - Google Patents

Verfahren zur herstellung von 1,4- benzodiazepinen

Info

Publication number
DE2640599A1
DE2640599A1 DE19762640599 DE2640599A DE2640599A1 DE 2640599 A1 DE2640599 A1 DE 2640599A1 DE 19762640599 DE19762640599 DE 19762640599 DE 2640599 A DE2640599 A DE 2640599A DE 2640599 A1 DE2640599 A1 DE 2640599A1
Authority
DE
Germany
Prior art keywords
benzophenone
trifluoroethyl
chloro
ammonium
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19762640599
Other languages
German (de)
English (en)
Other versions
DE2640599C2 (cg-RX-API-DMAC7.html
Inventor
Walter Schlesinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD International Holdings GmbH
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Priority to DE19762640599 priority Critical patent/DE2640599A1/de
Publication of DE2640599A1 publication Critical patent/DE2640599A1/de
Application granted granted Critical
Publication of DE2640599C2 publication Critical patent/DE2640599C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19762640599 1976-09-09 1976-09-09 Verfahren zur herstellung von 1,4- benzodiazepinen Granted DE2640599A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19762640599 DE2640599A1 (de) 1976-09-09 1976-09-09 Verfahren zur herstellung von 1,4- benzodiazepinen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762640599 DE2640599A1 (de) 1976-09-09 1976-09-09 Verfahren zur herstellung von 1,4- benzodiazepinen

Publications (2)

Publication Number Publication Date
DE2640599A1 true DE2640599A1 (de) 1978-03-16
DE2640599C2 DE2640599C2 (cg-RX-API-DMAC7.html) 1987-11-05

Family

ID=5987537

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762640599 Granted DE2640599A1 (de) 1976-09-09 1976-09-09 Verfahren zur herstellung von 1,4- benzodiazepinen

Country Status (1)

Country Link
DE (1) DE2640599A1 (cg-RX-API-DMAC7.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8796261B2 (en) 2010-12-02 2014-08-05 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9493483B2 (en) 2012-06-06 2016-11-15 Constellation Pharmaceuticals, Inc. Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2120441C1 (ru) * 1996-10-18 1998-10-20 Олег Иванович Лукашов Способ получения 7-бром-1,3-дигидро-5-/2-хлорфенил/-2н-1,4-бензидиазепин-2-она, промежуточное соединение 5-бром-2-/2-хлорацетамидо/-2'-хлорбензофенон

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.Het.Chem., 7, 1173, 1970 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8796261B2 (en) 2010-12-02 2014-08-05 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9522920B2 (en) 2010-12-02 2016-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9493483B2 (en) 2012-06-06 2016-11-15 Constellation Pharmaceuticals, Inc. Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
US9925197B2 (en) 2012-06-06 2018-03-27 Constellation Pharmaceuticals, Inc. Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide

Also Published As

Publication number Publication date
DE2640599C2 (cg-RX-API-DMAC7.html) 1987-11-05

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition