DE2628558C2 - - Google Patents

Info

Publication number
DE2628558C2
DE2628558C2 DE2628558A DE2628558A DE2628558C2 DE 2628558 C2 DE2628558 C2 DE 2628558C2 DE 2628558 A DE2628558 A DE 2628558A DE 2628558 A DE2628558 A DE 2628558A DE 2628558 C2 DE2628558 C2 DE 2628558C2
Authority
DE
Germany
Prior art keywords
lofepramine
hydrochloride
acetate
propyl
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2628558A
Other languages
German (de)
English (en)
Other versions
DE2628558A1 (de
Inventor
Edgar Eriksoo
Sten Sture Haelsingborg Se Kelfve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AB
Original Assignee
LEO HAELSOVAEGEN HAELSINGBORG SE AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LEO HAELSOVAEGEN HAELSINGBORG SE AB filed Critical LEO HAELSOVAEGEN HAELSINGBORG SE AB
Publication of DE2628558A1 publication Critical patent/DE2628558A1/de
Application granted granted Critical
Publication of DE2628558C2 publication Critical patent/DE2628558C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19762628558 1975-07-03 1976-06-25 Verfahren zur herstellung von lofepraminhydrochlorid Granted DE2628558A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28145/75A GB1497306A (en) 1975-07-03 1975-07-03 Preparation of lofepramine and its hydrochloride

Publications (2)

Publication Number Publication Date
DE2628558A1 DE2628558A1 (de) 1977-01-20
DE2628558C2 true DE2628558C2 (enExample) 1989-11-16

Family

ID=10270996

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762628558 Granted DE2628558A1 (de) 1975-07-03 1976-06-25 Verfahren zur herstellung von lofepraminhydrochlorid

Country Status (10)

Country Link
US (1) US4172074A (enExample)
JP (1) JPS6014030B2 (enExample)
BE (1) BE843691A (enExample)
CA (1) CA1079274A (enExample)
CH (1) CH618686A5 (enExample)
DE (1) DE2628558A1 (enExample)
FR (1) FR2316234A1 (enExample)
GB (1) GB1497306A (enExample)
IE (1) IE43255B1 (enExample)
SE (1) SE7607565L (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108119A1 (de) * 1991-03-13 1992-09-17 Jellalabad Ltd Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ293642A (en) * 1994-10-05 1998-10-28 Cari Loder Prevention or treatment of nerve damage caused by multiple sclerosis and other demyelinating conditions with a tri- or tetracyclic antidepressant or a monoamine oxidase inhibitor and a neurotransmitter-inducer
GB2308065B (en) * 1994-10-05 1999-01-13 Cari Loder Treatment of multiple sclerosis (MS) and other demyelinating conditions
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
JP2008514689A (ja) * 2004-10-01 2008-05-08 ニューロキュア リミテッド Ａｄｈｄ、ｃｆｓ、ｆｍおよび鬱病の処置のためのロフェプラミンの薬学的な組成物の使用
WO2007008758A2 (en) 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (en) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation of neurogenesis by melatoninergic ligands
CA2675132A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
US20110034565A1 (en) 2008-04-18 2011-02-10 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108119A1 (de) * 1991-03-13 1992-09-17 Jellalabad Ltd Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten

Also Published As

Publication number Publication date
SE7607565L (sv) 1977-01-04
GB1497306A (en) 1978-01-05
CA1079274A (en) 1980-06-10
FR2316234A1 (fr) 1977-01-28
JPS6014030B2 (ja) 1985-04-11
CH618686A5 (enExample) 1980-08-15
IE43255B1 (en) 1981-01-14
FR2316234B1 (enExample) 1979-06-08
BE843691A (fr) 1977-01-03
US4172074A (en) 1979-10-23
IE43255L (en) 1977-01-03
DE2628558A1 (de) 1977-01-20
JPS527982A (en) 1977-01-21

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: BERENDT, T., DIPL.-CHEM. DR., PAT.-ANW., 8000 MUEN

8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: H. LUNDBECK AB, HELSINGBORG, SE

8328 Change in the person/name/address of the agent

Free format text: BERENDT, T., DIPL.-CHEM. DR. LEYH, H., DIPL.-ING. DR.-ING. HERING, H., DIPL.-ING., PAT.-ANWAELTE, 81667 MUENCHEN