FR2316234A1 - Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine) - Google Patents

Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine)

Info

Publication number
FR2316234A1
FR2316234A1 FR7620102A FR7620102A FR2316234A1 FR 2316234 A1 FR2316234 A1 FR 2316234A1 FR 7620102 A FR7620102 A FR 7620102A FR 7620102 A FR7620102 A FR 7620102A FR 2316234 A1 FR2316234 A1 FR 2316234A1
Authority
FR
France
Prior art keywords
chlorhydra
acteophenone
lofepramine
dibenz
azepinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7620102A
Other languages
English (en)
Other versions
FR2316234B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo AB
Original Assignee
Leo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo AB filed Critical Leo AB
Publication of FR2316234A1 publication Critical patent/FR2316234A1/fr
Application granted granted Critical
Publication of FR2316234B1 publication Critical patent/FR2316234B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7620102A 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine) Granted FR2316234A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28145/75A GB1497306A (en) 1975-07-03 1975-07-03 Preparation of lofepramine and its hydrochloride

Publications (2)

Publication Number Publication Date
FR2316234A1 true FR2316234A1 (fr) 1977-01-28
FR2316234B1 FR2316234B1 (fr) 1979-06-08

Family

ID=10270996

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7620102A Granted FR2316234A1 (fr) 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de 4'-chloro-2-((3-(10,11-dihydro-5h-dibenz (b, f) azepinyl-(5))-propyl)-methylamino)-acetophenone (ou chlorhydrate de lofepramine)

Country Status (10)

Country Link
US (1) US4172074A (fr)
JP (1) JPS6014030B2 (fr)
BE (1) BE843691A (fr)
CA (1) CA1079274A (fr)
CH (1) CH618686A5 (fr)
DE (1) DE2628558A1 (fr)
FR (1) FR2316234A1 (fr)
GB (1) GB1497306A (fr)
IE (1) IE43255B1 (fr)
SE (1) SE7607565L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019599A1 (fr) * 1991-03-13 1992-11-12 Jellalabad Ltd. Procede de purification de la lofepramine par cristallisation

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011009A1 (fr) 1994-10-05 1996-04-18 Cari Loder Traitement de la sclerose en plaques (ms) et d'autres maladies demyelinisantes utilisant la lofepramine en combinaison avec l-phenylalanine, tyrosine ou tryptophane et eventuellement un compose de la vitamine b¿12?
GB2308065B (en) * 1994-10-05 1999-01-13 Cari Loder Treatment of multiple sclerosis (MS) and other demyelinating conditions
WO2005060968A1 (fr) 2003-12-11 2005-07-07 Sepracor Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
AU2005290980A1 (en) * 2004-10-01 2006-04-13 Neurocure Ltd Use of pharmaceutical compositions of lofepramine for the treatment of ADHD, CFS, FM and depression
US20070015138A1 (en) * 2005-07-08 2007-01-18 Braincells, Inc. Methods for identifying agents and conditions that modulate neurogenesis
WO2007053596A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (fr) 2006-05-09 2009-02-25 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080167363A1 (en) * 2006-12-28 2008-07-10 Braincells, Inc Modulation of Neurogenesis By Melatoninergic Agents
WO2008086483A2 (fr) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation de la neurogenèse en utilisant du modafinil
WO2009128058A1 (fr) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Produits psycho-pharmaceutiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019599A1 (fr) * 1991-03-13 1992-11-12 Jellalabad Ltd. Procede de purification de la lofepramine par cristallisation

Also Published As

Publication number Publication date
CH618686A5 (fr) 1980-08-15
DE2628558C2 (fr) 1989-11-16
FR2316234B1 (fr) 1979-06-08
BE843691A (fr) 1977-01-03
US4172074A (en) 1979-10-23
JPS6014030B2 (ja) 1985-04-11
DE2628558A1 (de) 1977-01-20
IE43255B1 (en) 1981-01-14
IE43255L (en) 1977-01-03
JPS527982A (en) 1977-01-21
SE7607565L (sv) 1977-01-04
GB1497306A (en) 1978-01-05
CA1079274A (fr) 1980-06-10

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