DE2614542C3 - Entnahme von Reaktionsgut aus steril geführten Prozessen und Vorrichtung zu seiner Durchführung - Google Patents
Entnahme von Reaktionsgut aus steril geführten Prozessen und Vorrichtung zu seiner DurchführungInfo
- Publication number
- DE2614542C3 DE2614542C3 DE2614542A DE2614542A DE2614542C3 DE 2614542 C3 DE2614542 C3 DE 2614542C3 DE 2614542 A DE2614542 A DE 2614542A DE 2614542 A DE2614542 A DE 2614542A DE 2614542 C3 DE2614542 C3 DE 2614542C3
- Authority
- DE
- Germany
- Prior art keywords
- sampling
- sterile
- reactor
- way valve
- flows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 28
- 239000000463 material Substances 0.000 title claims description 12
- 238000005070 sampling Methods 0.000 claims description 64
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 230000000994 depressogenic effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 40
- 239000003570 air Substances 0.000 description 31
- 239000002775 capsule Substances 0.000 description 24
- 238000011109 contamination Methods 0.000 description 9
- 229910052782 aluminium Inorganic materials 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 239000011888 foil Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
- G01N2001/1436—Ejector
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Hydrology & Water Resources (AREA)
- Sampling And Sample Adjustment (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2614542A DE2614542C3 (de) | 1976-04-03 | 1976-04-03 | Entnahme von Reaktionsgut aus steril geführten Prozessen und Vorrichtung zu seiner Durchführung |
| DE2659923A DE2659923C2 (de) | 1976-04-03 | 1976-04-03 | Entnahme von durch Umgebungsluft unkontaminierten Probegutes aus unter sterilen Bedingungen arbeitenden Reaktoren |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2614542A DE2614542C3 (de) | 1976-04-03 | 1976-04-03 | Entnahme von Reaktionsgut aus steril geführten Prozessen und Vorrichtung zu seiner Durchführung |
| DE2659923A DE2659923C2 (de) | 1976-04-03 | 1976-04-03 | Entnahme von durch Umgebungsluft unkontaminierten Probegutes aus unter sterilen Bedingungen arbeitenden Reaktoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2614542A1 DE2614542A1 (de) | 1977-11-10 |
| DE2614542B2 DE2614542B2 (enExample) | 1978-03-02 |
| DE2614542C3 true DE2614542C3 (de) | 1978-11-02 |
Family
ID=32772722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2614542A Expired DE2614542C3 (de) | 1976-04-03 | 1976-04-03 | Entnahme von Reaktionsgut aus steril geführten Prozessen und Vorrichtung zu seiner Durchführung |
| DE2659923A Expired DE2659923C2 (de) | 1976-04-03 | 1976-04-03 | Entnahme von durch Umgebungsluft unkontaminierten Probegutes aus unter sterilen Bedingungen arbeitenden Reaktoren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2659923A Expired DE2659923C2 (de) | 1976-04-03 | 1976-04-03 | Entnahme von durch Umgebungsluft unkontaminierten Probegutes aus unter sterilen Bedingungen arbeitenden Reaktoren |
Country Status (1)
| Country | Link |
|---|---|
| DE (2) | DE2614542C3 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172838B1 (de) * | 1984-02-20 | 1988-05-25 | Pio Meyer | Probenahme - vorrichtung |
| SE453752B (sv) * | 1986-07-04 | 1988-02-29 | Alfa Laval Food & Dairy Eng | Forfarande och anordning for aseptisk overforing av en vetskemengd, serskilt vid provtagning |
| US4999307A (en) * | 1989-02-13 | 1991-03-12 | Baxter International Inc. | Apparatus and method for periodic aseptic withdrawal of liquid samples from a sterile liquid source |
| DE4432599C2 (de) * | 1994-09-13 | 1996-10-31 | Thomae Gmbh Dr K | Probenahmeverfahren für die Bioprozeßanalytik |
| EP1072877A1 (de) * | 1999-07-24 | 2001-01-31 | Jacob Dr.-Ing. Hoiss | Vorrichtung zum Prüfen der mikrobiologischen Qualität eines gasförmigen Mediums |
| EP1508791A1 (en) * | 2003-08-22 | 2005-02-23 | Ismatec SA, Laboratoriumstechnik | Device for automated bioreactor sampling |
-
1976
- 1976-04-03 DE DE2614542A patent/DE2614542C3/de not_active Expired
- 1976-04-03 DE DE2659923A patent/DE2659923C2/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2614542B2 (enExample) | 1978-03-02 |
| DE2614542A1 (de) | 1977-11-10 |
| DE2659923B1 (de) | 1978-09-14 |
| DE2659923C2 (de) | 1979-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OI | Miscellaneous see part 1 | ||
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |