DE2504373A1 - Attenuierte influenza-b-virus- rekombinante, verfahren zu ihrer herstellung und influenza-b-virus-lebendvaccine - Google Patents
Attenuierte influenza-b-virus- rekombinante, verfahren zu ihrer herstellung und influenza-b-virus-lebendvaccineInfo
- Publication number
- DE2504373A1 DE2504373A1 DE19752504373 DE2504373A DE2504373A1 DE 2504373 A1 DE2504373 A1 DE 2504373A1 DE 19752504373 DE19752504373 DE 19752504373 DE 2504373 A DE2504373 A DE 2504373A DE 2504373 A1 DE2504373 A1 DE 2504373A1
- Authority
- DE
- Germany
- Prior art keywords
- virus
- influenza
- strain
- atcc
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 241000713196 Influenza B virus Species 0.000 title claims description 55
- 230000002238 attenuated effect Effects 0.000 title claims description 28
- 238000004519 manufacturing process Methods 0.000 title claims description 18
- 235000013601 eggs Nutrition 0.000 claims description 49
- 229960005486 vaccine Drugs 0.000 claims description 47
- 241000700605 Viruses Species 0.000 claims description 41
- 230000012447 hatching Effects 0.000 claims description 34
- 239000001888 Peptone Substances 0.000 claims description 14
- 108010080698 Peptones Proteins 0.000 claims description 14
- 235000019319 peptone Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- 239000003381 stabilizer Substances 0.000 claims description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 10
- 229960004793 sucrose Drugs 0.000 claims description 10
- 241000712431 Influenza A virus Species 0.000 claims description 7
- 230000006798 recombination Effects 0.000 claims description 5
- 238000005215 recombination Methods 0.000 claims description 5
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 3
- 230000000644 propagated effect Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 31
- 239000012530 fluid Substances 0.000 description 25
- 239000011521 glass Substances 0.000 description 17
- 239000000463 material Substances 0.000 description 17
- 238000002255 vaccination Methods 0.000 description 14
- 230000035931 haemagglutination Effects 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 238000010790 dilution Methods 0.000 description 11
- 239000012895 dilution Substances 0.000 description 11
- 239000003112 inhibitor Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- 239000002504 physiological saline solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 101710154606 Hemagglutinin Proteins 0.000 description 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 6
- 101710176177 Protein A56 Proteins 0.000 description 6
- 239000000185 hemagglutinin Substances 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 229960003971 influenza vaccine Drugs 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 210000003711 chorioallantoic membrane Anatomy 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000003067 hemagglutinative effect Effects 0.000 description 4
- 230000036512 infertility Effects 0.000 description 4
- 206010022000 influenza Diseases 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000008542 thermal sensitivity Effects 0.000 description 4
- 241000282339 Mustela Species 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 208000037798 influenza B Diseases 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229940031416 bivalent vaccine Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 229960001226 live attenuated influenza Drugs 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000007918 pathogenicity Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- 238000009331 sowing Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 1
- DWKNOLCXIFYNFV-HSZRJFAPSA-N 2-[[(2r)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-n,n,6-trimethylpyridine-4-carboxamide Chemical compound CN(C)C(=O)C1=CC(C)=NC(NC(=O)[C@@H]2N(C(=O)CC2)C2CCN(CC=3C=C(C)C(Cl)=CC=3)CC2)=C1 DWKNOLCXIFYNFV-HSZRJFAPSA-N 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000282341 Mustela putorius furo Species 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000009021 pre-vaccination Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43917674A | 1974-02-04 | 1974-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2504373A1 true DE2504373A1 (de) | 1975-08-07 |
Family
ID=23743623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752504373 Withdrawn DE2504373A1 (de) | 1974-02-04 | 1975-02-03 | Attenuierte influenza-b-virus- rekombinante, verfahren zu ihrer herstellung und influenza-b-virus-lebendvaccine |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS50107122A (en, 2012) |
| AT (1) | AT338416B (en, 2012) |
| BE (1) | BE824970A (en, 2012) |
| CA (1) | CA1047922A (en, 2012) |
| CH (1) | CH596316A5 (en, 2012) |
| CS (1) | CS202545B2 (en, 2012) |
| DD (1) | DD116474A5 (en, 2012) |
| DE (1) | DE2504373A1 (en, 2012) |
| DK (1) | DK141926B (en, 2012) |
| ES (1) | ES434384A1 (en, 2012) |
| FI (1) | FI750260A7 (en, 2012) |
| FR (1) | FR2259616B1 (en, 2012) |
| GB (1) | GB1439742A (en, 2012) |
| HU (1) | HU170522B (en, 2012) |
| IE (1) | IE42043B1 (en, 2012) |
| IL (1) | IL46446A (en, 2012) |
| LU (1) | LU71784A1 (en, 2012) |
| NL (1) | NL7501028A (en, 2012) |
| NO (1) | NO750295L (en, 2012) |
| SE (1) | SE424503B (en, 2012) |
| ZA (1) | ZA75248B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2588918A (en) * | 1947-11-07 | 1952-03-11 | William T Graham | Mechanism for raising and lowering plow frames relative to the ground wheels |
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
-
1975
- 1975-01-14 ZA ZA00750248A patent/ZA75248B/xx unknown
- 1975-01-16 IL IL46446A patent/IL46446A/xx unknown
- 1975-01-16 DK DK9775AA patent/DK141926B/da not_active IP Right Cessation
- 1975-01-20 SE SE7500549A patent/SE424503B/xx unknown
- 1975-01-23 CA CA218,508A patent/CA1047922A/en not_active Expired
- 1975-01-24 FR FR7502331A patent/FR2259616B1/fr not_active Expired
- 1975-01-27 IE IE160/75A patent/IE42043B1/en unknown
- 1975-01-29 NL NL7501028A patent/NL7501028A/xx not_active Application Discontinuation
- 1975-01-30 BE BE152864A patent/BE824970A/xx not_active IP Right Cessation
- 1975-01-30 NO NO750295A patent/NO750295L/no unknown
- 1975-01-31 FI FI750260A patent/FI750260A7/fi not_active Application Discontinuation
- 1975-02-01 ES ES434384A patent/ES434384A1/es not_active Expired
- 1975-02-03 GB GB453575A patent/GB1439742A/en not_active Expired
- 1975-02-03 AT AT76675A patent/AT338416B/de not_active IP Right Cessation
- 1975-02-03 DD DD183973A patent/DD116474A5/xx unknown
- 1975-02-03 CH CH124275A patent/CH596316A5/xx not_active IP Right Cessation
- 1975-02-03 JP JP50014790A patent/JPS50107122A/ja active Pending
- 1975-02-03 HU HUTE805A patent/HU170522B/hu unknown
- 1975-02-03 DE DE19752504373 patent/DE2504373A1/de not_active Withdrawn
- 1975-02-03 CS CS75669A patent/CS202545B2/cs unknown
- 1975-02-03 LU LU71784A patent/LU71784A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE424503B (sv) | 1982-07-26 |
| ATA76675A (de) | 1976-12-15 |
| LU71784A1 (en, 2012) | 1975-06-24 |
| DK9775A (en, 2012) | 1975-09-29 |
| HU170522B (en, 2012) | 1977-06-28 |
| NL7501028A (nl) | 1975-08-06 |
| CA1047922A (en) | 1979-02-06 |
| NO750295L (en, 2012) | 1975-09-01 |
| DD116474A5 (en, 2012) | 1975-11-20 |
| CH596316A5 (en, 2012) | 1978-03-15 |
| FR2259616B1 (en, 2012) | 1980-01-04 |
| FR2259616A1 (en, 2012) | 1975-08-29 |
| CS202545B2 (en) | 1981-01-30 |
| GB1439742A (en) | 1976-06-16 |
| ES434384A1 (es) | 1976-12-01 |
| ZA75248B (en) | 1976-01-28 |
| AT338416B (de) | 1977-08-25 |
| IE42043B1 (en) | 1980-05-21 |
| JPS50107122A (en, 2012) | 1975-08-23 |
| BE824970A (fr) | 1975-07-30 |
| DK141926B (da) | 1980-07-21 |
| SE7500549L (en, 2012) | 1975-08-05 |
| FI750260A7 (en, 2012) | 1975-08-05 |
| AU7734675A (en) | 1976-07-15 |
| DK141926C (en, 2012) | 1981-01-19 |
| IL46446A (en) | 1978-01-31 |
| IL46446A0 (en) | 1975-04-25 |
| IE42043L (en) | 1975-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OGA | New person/name/address of the applicant | ||
| 8139 | Disposal/non-payment of the annual fee |