GB1439742A - Live influenza type b virus vaccines and preparation thereof - Google Patents

Live influenza type b virus vaccines and preparation thereof

Info

Publication number
GB1439742A
GB1439742A GB453575A GB453575A GB1439742A GB 1439742 A GB1439742 A GB 1439742A GB 453575 A GB453575 A GB 453575A GB 453575 A GB453575 A GB 453575A GB 1439742 A GB1439742 A GB 1439742A
Authority
GB
United Kingdom
Prior art keywords
strain
attenuated
recombinant
influenza type
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB453575A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recherche et Industrie Therapeutiques
Original Assignee
Recherche et Industrie Therapeutiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recherche et Industrie Therapeutiques filed Critical Recherche et Industrie Therapeutiques
Publication of GB1439742A publication Critical patent/GB1439742A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16211Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1439742 Nasal influenza vaccine RECHERCHE ET INDUSTRIE THERAPEUTIQUES 3 Feb 1975 [4 Feb 1974] 4535/75 Heading A5B A live influenza virus vaccine suitable for nasal administration comprises, as active ingredient an attenuated influenza type B virus strain recombinant obtained from (i) a vaccinal and attenuated influenza type B virus strain and (ii) another influenza type B virus strain, said recombinant having at least one marker property of said attenuated strain which is not shared by said other strain and the antigenic composition of said other strain. The attenuated strain may be Brigit strain. The recombinant may be influenza type BR5, R22 or R22 strain (ATCC VR787, 788 and 789 respectively). The recombinant may be prepared by combining the attenuated strain and the other strain in the allantoic cavity of embryonated chicken eggs, and isolating the recombinant by selective pressure. The isolate may be grown in the allantoic cavity of chicken eggs, admixed with a stabilizer, e.g. peptone or sugar, and freeze-dried. The vaccine may also include an attenuated influenza type A virus vaccine, e.g. Alice strain (ATCC VR776).
GB453575A 1974-02-04 1975-02-03 Live influenza type b virus vaccines and preparation thereof Expired GB1439742A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43917674A 1974-02-04 1974-02-04

Publications (1)

Publication Number Publication Date
GB1439742A true GB1439742A (en) 1976-06-16

Family

ID=23743623

Family Applications (1)

Application Number Title Priority Date Filing Date
GB453575A Expired GB1439742A (en) 1974-02-04 1975-02-03 Live influenza type b virus vaccines and preparation thereof

Country Status (21)

Country Link
JP (1) JPS50107122A (en)
AT (1) AT338416B (en)
BE (1) BE824970A (en)
CA (1) CA1047922A (en)
CH (1) CH596316A5 (en)
CS (1) CS202545B2 (en)
DD (1) DD116474A5 (en)
DE (1) DE2504373A1 (en)
DK (1) DK141926B (en)
ES (1) ES434384A1 (en)
FI (1) FI750260A (en)
FR (1) FR2259616B1 (en)
GB (1) GB1439742A (en)
HU (1) HU170522B (en)
IE (1) IE42043B1 (en)
IL (1) IL46446A (en)
LU (1) LU71784A1 (en)
NL (1) NL7501028A (en)
NO (1) NO750295L (en)
SE (1) SE424503B (en)
ZA (1) ZA75248B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2588918A (en) * 1947-11-07 1952-03-11 William T Graham Mechanism for raising and lowering plow frames relative to the ground wheels
JPS6042209B2 (en) * 1974-05-31 1985-09-20 北里研究所(社団法人) A method for acclimating fresh influenza virus isolates to embryonated chicken eggs in a short period of time

Also Published As

Publication number Publication date
IL46446A (en) 1978-01-31
FR2259616A1 (en) 1975-08-29
ZA75248B (en) 1976-01-28
IE42043B1 (en) 1980-05-21
ES434384A1 (en) 1976-12-01
LU71784A1 (en) 1975-06-24
BE824970A (en) 1975-07-30
NO750295L (en) 1975-09-01
SE7500549L (en) 1975-08-05
JPS50107122A (en) 1975-08-23
SE424503B (en) 1982-07-26
DK9775A (en) 1975-09-29
FI750260A (en) 1975-08-05
DK141926B (en) 1980-07-21
CH596316A5 (en) 1978-03-15
AT338416B (en) 1977-08-25
FR2259616B1 (en) 1980-01-04
CS202545B2 (en) 1981-01-30
DD116474A5 (en) 1975-11-20
CA1047922A (en) 1979-02-06
NL7501028A (en) 1975-08-06
DK141926C (en) 1981-01-19
ATA76675A (en) 1976-12-15
AU7734675A (en) 1976-07-15
HU170522B (en) 1977-06-28
IE42043L (en) 1975-08-04
IL46446A0 (en) 1975-04-25
DE2504373A1 (en) 1975-08-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee