DE2450523C3 - Verfahren zum immunologischen Nachweis von Proteinen - Google Patents
Verfahren zum immunologischen Nachweis von ProteinenInfo
- Publication number
- DE2450523C3 DE2450523C3 DE2450523A DE2450523A DE2450523C3 DE 2450523 C3 DE2450523 C3 DE 2450523C3 DE 2450523 A DE2450523 A DE 2450523A DE 2450523 A DE2450523 A DE 2450523A DE 2450523 C3 DE2450523 C3 DE 2450523C3
- Authority
- DE
- Germany
- Prior art keywords
- receptors
- antigen
- receptor
- sample
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 23
- 238000001514 detection method Methods 0.000 title claims description 8
- 102000004169 proteins and genes Human genes 0.000 title claims description 8
- 108090000623 proteins and genes Proteins 0.000 title claims description 8
- 230000001900 immune effect Effects 0.000 title claims description 4
- 102000036639 antigens Human genes 0.000 claims description 65
- 108091007433 antigens Proteins 0.000 claims description 65
- 239000000427 antigen Substances 0.000 claims description 64
- 239000000523 sample Substances 0.000 claims description 29
- 208000006454 hepatitis Diseases 0.000 claims description 14
- 231100000283 hepatitis Toxicity 0.000 claims description 14
- 239000012496 blank sample Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000007790 solid phase Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- 239000007787 solid Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 238000004435 EPR spectroscopy Methods 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/410,066 US3949064A (en) | 1973-10-26 | 1973-10-26 | Method of detecting antigens or antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2450523A1 DE2450523A1 (de) | 1975-05-22 |
| DE2450523B2 DE2450523B2 (de) | 1976-10-07 |
| DE2450523C3 true DE2450523C3 (de) | 1978-06-22 |
Family
ID=23623067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2450523A Expired DE2450523C3 (de) | 1973-10-26 | 1974-10-24 | Verfahren zum immunologischen Nachweis von Proteinen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US3949064A (https=) |
| JP (1) | JPS5762020B2 (https=) |
| AU (1) | AU476619B2 (https=) |
| BE (1) | BE820660A (https=) |
| BR (1) | BR7408886A (https=) |
| CA (1) | CA1036493A (https=) |
| DE (1) | DE2450523C3 (https=) |
| ES (1) | ES431413A1 (https=) |
| FR (1) | FR2249334B1 (https=) |
| GB (1) | GB1436934A (https=) |
| IL (1) | IL45707A (https=) |
| LU (1) | LU71027A1 (https=) |
| NL (1) | NL7413552A (https=) |
| SE (1) | SE7413484L (https=) |
| ZA (1) | ZA746098B (https=) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172117A (en) * | 1974-05-20 | 1979-10-23 | Biotest-Serum-Institut Gmbh | Method for the simultaneous measurement of antigens and their antibodies by solid-phase radioimmunoassay |
| US4225784A (en) * | 1976-06-17 | 1980-09-30 | Smith Kline Instruments, Inc. | Covalently bound biological substances to plastic materials and use in radioassay |
| AT343822B (de) * | 1976-08-20 | 1978-06-26 | Immuno Ag | Radioimmunologisches verfahren und einrichtung zur bestimmung von antigenen |
| JPS604422B2 (ja) * | 1976-10-07 | 1985-02-04 | 持田製薬株式会社 | 抗原の定量方法 |
| USRE34394E (en) * | 1978-01-23 | 1993-09-28 | Baxter Diagnostics Inc. | Method and composition for double receptor, specific binding assays |
| JPS608745B2 (ja) * | 1978-02-14 | 1985-03-05 | 三洋化成工業株式会社 | 免疫活性物質−つや消しガラス複合体，その製造法及び該複合体を含有してなる測定試薬 |
| US4242322A (en) * | 1978-06-07 | 1980-12-30 | Electro-Nucleonics Laboratories, Inc. | Methods and materials for detecting antigens and antibodies |
| US4393040A (en) * | 1981-03-24 | 1983-07-12 | Lopapa Institute, Inc. | In-vitro diagnostic method for detection of acetylsalicylic acid ingestion |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| EP0135277B1 (en) * | 1983-07-21 | 1986-10-29 | Scripps Clinic And Research Foundation | Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mrnas, receptors, methods and diagnostics using the same |
| US5242798A (en) * | 1983-07-21 | 1993-09-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same |
| DE3586772T2 (de) * | 1984-07-24 | 1993-03-04 | Coselco Mimotopes Pty Ltd | Verfahren zur bestimmung von mimotopen. |
| US5182082A (en) * | 1991-01-23 | 1993-01-26 | Becton, Dickinson And Company | Multiple aliquot device for distributing a liquid solution into a well |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5877028A (en) * | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US5998220A (en) * | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US5348867A (en) * | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
| US5698686A (en) * | 1994-10-20 | 1997-12-16 | Arch Development Corporation | Yeast telomerase compositions |
| US5807552A (en) * | 1995-08-04 | 1998-09-15 | Board Of Regents, The University Of Texas System | Compositions for conferring immunogenicity to a substance and uses thereof |
| JP2002515965A (ja) * | 1995-08-18 | 2002-05-28 | ダブリュー． ランドリ，ドナルド | 抗体触媒反応の調節による有機化合物の検出 |
| US6689757B1 (en) | 1996-02-12 | 2004-02-10 | M.L. Laboratories Plc | Methods for vaccination and vaccines therefor |
| US20020034732A1 (en) * | 1997-07-30 | 2002-03-21 | Daniel J. Capon | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
| US6610838B1 (en) | 1997-09-10 | 2003-08-26 | Symbicom Aktiebolag | P13 antigens from Borrelia |
| US6656471B1 (en) | 1998-11-17 | 2003-12-02 | Board Of Regents, The University Of Texas System | HIV-specific T-cell induction |
| CN1484700A (zh) * | 2000-11-02 | 2004-03-24 | �¼��¹�����ѧ | aopB基因,蛋白,同系物,片段和它们的变体,以及它们在细胞表面展示方面的应用 |
| WO2004058181A2 (en) | 2002-12-20 | 2004-07-15 | Board Of Regents, The University Of Texas System | Vmp-like sequences of pathogenic borrelia species and strains |
| CN1820020B (zh) * | 2003-05-06 | 2010-04-28 | 技术持有有限公司 | Sars-冠状病毒病毒样颗粒以及应用方法 |
| WO2005032455A2 (en) | 2003-05-23 | 2005-04-14 | Board Of Regents | Combinatorially selected phosphorodithioate aptamer targeting ap-1 |
| AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| CN101657464A (zh) * | 2007-02-02 | 2010-02-24 | 贝勒研究院 | 与靶向人源化单克隆抗体复合的多变量抗原 |
| KR20090114430A (ko) | 2007-02-02 | 2009-11-03 | 베일러 리서치 인스티튜트 | 항원-제시 세포 상에서 발현된 ｄｃｉｒ에 대한 항원 표적화에 기초한 백신 |
| TWI422594B (zh) * | 2007-02-02 | 2014-01-11 | Baylor Res Inst | 經由樹狀細胞去唾液酸糖蛋白受體（ｄｃ-ａｓｇｐｒ）接合抗原呈現細胞之藥劑 |
| NZ595319A (en) * | 2007-02-23 | 2012-09-28 | Baylor Res Inst | Activation of human antigen-presenting cells through clec-6 |
| EP2132226B1 (en) | 2007-02-23 | 2019-03-27 | Baylor Research Institute | Activation of human antigen-presenting cells through dendritic cell lectin-like oxidized ldl receptor-1 (lox-1) |
| MX2009008926A (es) | 2007-02-23 | 2009-09-14 | Baylor Res Inst | Aplicaciones terapeuticas de activacion de celulas que presentan antigeno humano por medio de detectina a-1. |
| US9138470B2 (en) * | 2007-11-02 | 2015-09-22 | The Johns Hopkins University | Multi-component L2 vaccine for prevention of human papilloma virus infection |
| ES2685823T3 (es) | 2008-07-16 | 2018-10-11 | Baylor Research Institute | Anticuerpos antagonistas anti-CD40 |
| EP2341929B1 (en) | 2008-10-06 | 2017-01-25 | University Of Chicago | Compositions and methods related to bacterial emp proteins |
| HUE026855T2 (en) | 2009-04-03 | 2016-07-28 | Univ Chicago | Compositions and methods related to protein a (spa) variants |
| WO2011100508A2 (en) | 2010-02-12 | 2011-08-18 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and compositions related to glycoprotein-immunoglobulin fusions |
| EP2555794A4 (en) | 2010-04-05 | 2014-01-15 | Univ Chicago | COMPOSITIONS AND METHODS RELATING TO PROTEIN A (SPA) ANTIBODIES AS IMMUNE REACTION AMPLIFIERS |
| CA2803298C (en) | 2010-07-02 | 2020-07-14 | The University Of Chicago | Compositions and methods related to protein a (spa) variants |
| EP2614074A1 (en) | 2010-09-09 | 2013-07-17 | The University of Chicago | Methods and compositions involving protective staphylococcal antigens |
| US9567346B2 (en) | 2010-10-29 | 2017-02-14 | Life Technologies Corporation | Biotin derivatives |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| JP6670106B2 (ja) | 2012-04-26 | 2020-03-18 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌コアグラーゼ抗原およびその使用方法 |
| BR112015006840A2 (pt) | 2012-09-27 | 2017-11-21 | Res Found Dev | vírus chikungunya atenuado |
| US10358667B2 (en) | 2013-03-07 | 2019-07-23 | University Of Maryland, Baltimore | Immunotherapeutic potential of modified lipooligosaccharides/lipid A |
| WO2015175957A1 (en) | 2014-05-16 | 2015-11-19 | Baylor Research Institute | Methods and compositions for treating autoimmune and inflammatory conditions |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| WO2019183500A1 (en) | 2018-03-23 | 2019-09-26 | Hung Chiung Yu | Coccidioides antigens and methods of their use |
| WO2020041360A1 (en) | 2018-08-21 | 2020-02-27 | Quidel Corporation | Dbpa antibodies and uses thereof |
| WO2020193718A1 (en) | 2019-03-27 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Recombinant proteins with cd40 activating properties |
| US12514914B2 (en) | 2019-05-14 | 2026-01-06 | The University Of Chicago | Methods and compositions comprising Staphylococcus protein a (SpA) variants |
| JP2023502712A (ja) | 2019-11-21 | 2023-01-25 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | 抗ｐｄ－１／ｉｌ－１５免疫サイトカインによる新しいｐｄ－１標的免疫療法 |
| US11376320B2 (en) | 2020-03-05 | 2022-07-05 | Iowa State University Research Foundation, Inc. | Immunogenic and vaccine compositions against SARS-CoV-2 |
| US20230183366A1 (en) | 2020-05-13 | 2023-06-15 | Inserm (Institut National De La Santé Et De La Recherch Médicale) | Recombinant proteins with ox40 activating properties |
| EP4469079A1 (en) | 2022-01-28 | 2024-12-04 | Pfizer Inc. | Coronavirus antigen variants |
| WO2025017036A1 (en) | 2023-07-17 | 2025-01-23 | Institut National de la Santé et de la Recherche Médicale | Alphavirus nsp3 helical tubular scaffolds |
| WO2025027492A1 (en) | 2023-07-31 | 2025-02-06 | Pfizer Inc. | Coronavirus antigen variants |
| WO2025257397A1 (en) | 2024-06-14 | 2025-12-18 | Institut National de la Santé et de la Recherche Médicale | Live attenuated bordetella vaccines capable of producing and secreting heterologous antigens |
| WO2026022374A1 (en) | 2024-07-26 | 2026-01-29 | Institut National de la Santé et de la Recherche Médicale | Methods for the prophylactic treatment of chikungunya virus infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE337223B (https=) * | 1967-05-23 | 1971-08-02 | Pharmacia Ab | |
| SE343210B (https=) * | 1967-12-20 | 1972-03-06 | Pharmacia Ab | |
| US3646346A (en) * | 1968-12-26 | 1972-02-29 | Pharmacia Ab | Antibody-coated tube system for radioimmunoassay |
| US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
-
1973
- 1973-10-26 US US05/410,066 patent/US3949064A/en not_active Expired - Lifetime
-
1974
- 1974-09-23 IL IL45707A patent/IL45707A/en unknown
- 1974-09-25 ZA ZA00746098A patent/ZA746098B/xx unknown
- 1974-09-27 GB GB4199674A patent/GB1436934A/en not_active Expired
- 1974-09-28 JP JP49112223A patent/JPS5762020B2/ja not_active Expired
- 1974-09-30 AU AU73787/74A patent/AU476619B2/en not_active Expired
- 1974-09-30 CA CA210,357A patent/CA1036493A/en not_active Expired
- 1974-10-01 LU LU71027A patent/LU71027A1/xx unknown
- 1974-10-03 BE BE149173A patent/BE820660A/xx unknown
- 1974-10-15 NL NL7413552A patent/NL7413552A/xx not_active Application Discontinuation
- 1974-10-15 FR FR7434561A patent/FR2249334B1/fr not_active Expired
- 1974-10-24 DE DE2450523A patent/DE2450523C3/de not_active Expired
- 1974-10-24 BR BR8886/74A patent/BR7408886A/pt unknown
- 1974-10-25 SE SE7413484A patent/SE7413484L/xx not_active Application Discontinuation
- 1974-10-26 ES ES431413A patent/ES431413A1/es not_active Expired
-
1978
- 1978-03-13 US US05/885,829 patent/USRE29955E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL45707A0 (en) | 1974-11-29 |
| AU476619B2 (en) | 1976-09-30 |
| AU7378774A (en) | 1976-04-01 |
| ZA746098B (en) | 1975-11-26 |
| ES431413A1 (es) | 1976-10-16 |
| USRE29955E (en) | 1979-04-03 |
| SE7413484L (https=) | 1975-04-28 |
| GB1436934A (en) | 1976-05-26 |
| IL45707A (en) | 1977-01-31 |
| JPS5762020B2 (https=) | 1982-12-27 |
| DE2450523A1 (de) | 1975-05-22 |
| FR2249334B1 (https=) | 1977-03-25 |
| JPS5075095A (https=) | 1975-06-20 |
| US3949064A (en) | 1976-04-06 |
| LU71027A1 (https=) | 1975-04-17 |
| FR2249334A1 (https=) | 1975-05-23 |
| CA1036493A (en) | 1978-08-15 |
| BE820660A (fr) | 1975-02-03 |
| DE2450523B2 (de) | 1976-10-07 |
| BR7408886A (pt) | 1976-05-04 |
| NL7413552A (nl) | 1975-04-29 |
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