DE2416904A1 - Verfahren zur herstellung kugelfoermigen phenacetingranulates und vorrichtung zur durchfuehrung des verfahrens - Google Patents
Verfahren zur herstellung kugelfoermigen phenacetingranulates und vorrichtung zur durchfuehrung des verfahrensInfo
- Publication number
- DE2416904A1 DE2416904A1 DE2416904A DE2416904A DE2416904A1 DE 2416904 A1 DE2416904 A1 DE 2416904A1 DE 2416904 A DE2416904 A DE 2416904A DE 2416904 A DE2416904 A DE 2416904A DE 2416904 A1 DE2416904 A1 DE 2416904A1
- Authority
- DE
- Germany
- Prior art keywords
- screw
- phenacetin
- spherical
- granules
- residence time
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 title claims description 36
- 229960003893 phenacetin Drugs 0.000 title claims description 21
- 238000000034 method Methods 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- 238000002844 melting Methods 0.000 claims description 14
- 230000008018 melting Effects 0.000 claims description 14
- 239000000155 melt Substances 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 5
- 241000237858 Gastropoda Species 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims description 2
- 238000007790 scraping Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 description 5
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 230000008646 thermal stress Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000007711 solidification Methods 0.000 description 3
- 230000008023 solidification Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 210000001080 enamel organ Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/04—Particle-shaped
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2416904A DE2416904A1 (de) | 1974-04-06 | 1974-04-06 | Verfahren zur herstellung kugelfoermigen phenacetingranulates und vorrichtung zur durchfuehrung des verfahrens |
| DK146075A DK146075A (en, 2012) | 1974-04-06 | 1975-04-04 | |
| NL7504057A NL7504057A (nl) | 1974-04-06 | 1975-04-04 | Werkwijze ter vervaardiging van kogelvormige fenacetinegranulaten en inrichting voor de uitvoering van deze werkwijze. |
| GB13920/75A GB1480187A (en) | 1974-04-06 | 1975-04-04 | Process for the preparation of phenacetin granules |
| LU72207A LU72207A1 (en, 2012) | 1974-04-06 | 1975-04-04 | |
| GB53147/75A GB1480189A (en) | 1974-04-06 | 1975-04-04 | Melting device |
| JP50040469A JPS50142724A (en, 2012) | 1974-04-06 | 1975-04-04 | |
| PL1975179331A PL99139B1 (pl) | 1974-04-06 | 1975-04-04 | Sposob wytwarzania kulistego granulatu fenacetyny |
| FR7510588A FR2266692B1 (en, 2012) | 1974-04-06 | 1975-04-04 | |
| DD185235A DD118525A5 (en, 2012) | 1974-04-06 | 1975-04-04 | |
| BE155087A BE827561A (fr) | 1974-04-06 | 1975-04-04 | Procede et dispositif de production de granules de phenacetine en particules spheriques |
| US05/720,650 US4086346A (en) | 1974-04-06 | 1976-09-07 | Preparation of melt-sprayed spherical phenacetin granules |
| US05/798,447 US4092089A (en) | 1974-04-06 | 1977-05-19 | Apparatus for the preparation of melt-sprayed spherical phenacetin granules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2416904A DE2416904A1 (de) | 1974-04-06 | 1974-04-06 | Verfahren zur herstellung kugelfoermigen phenacetingranulates und vorrichtung zur durchfuehrung des verfahrens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2416904A1 true DE2416904A1 (de) | 1975-10-16 |
Family
ID=5912382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2416904A Pending DE2416904A1 (de) | 1974-04-06 | 1974-04-06 | Verfahren zur herstellung kugelfoermigen phenacetingranulates und vorrichtung zur durchfuehrung des verfahrens |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS50142724A (en, 2012) |
| BE (1) | BE827561A (en, 2012) |
| DD (1) | DD118525A5 (en, 2012) |
| DE (1) | DE2416904A1 (en, 2012) |
| DK (1) | DK146075A (en, 2012) |
| FR (1) | FR2266692B1 (en, 2012) |
| GB (2) | GB1480187A (en, 2012) |
| LU (1) | LU72207A1 (en, 2012) |
| NL (1) | NL7504057A (en, 2012) |
| PL (1) | PL99139B1 (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3833446A1 (de) * | 1988-10-01 | 1990-04-05 | Hoechst Ag | Verfahren zur herstellung von arzneimittelwirkstoff-partikeln mit verbesserten fliess-, lager- und formulierungseigenschaften sowie arzneimittel, die diese arzneimittelwirkstoff-partikeln enthalten |
| FR2657257B1 (fr) * | 1990-01-19 | 1994-09-02 | Rhone Poulenc Sante | Procede de preparation de medicaments sous forme de perles. |
-
1974
- 1974-04-06 DE DE2416904A patent/DE2416904A1/de active Pending
-
1975
- 1975-04-04 DK DK146075A patent/DK146075A/da not_active IP Right Cessation
- 1975-04-04 GB GB13920/75A patent/GB1480187A/en not_active Expired
- 1975-04-04 NL NL7504057A patent/NL7504057A/xx not_active Application Discontinuation
- 1975-04-04 LU LU72207A patent/LU72207A1/xx unknown
- 1975-04-04 FR FR7510588A patent/FR2266692B1/fr not_active Expired
- 1975-04-04 PL PL1975179331A patent/PL99139B1/pl unknown
- 1975-04-04 GB GB53147/75A patent/GB1480189A/en not_active Expired
- 1975-04-04 JP JP50040469A patent/JPS50142724A/ja active Pending
- 1975-04-04 BE BE155087A patent/BE827561A/xx unknown
- 1975-04-04 DD DD185235A patent/DD118525A5/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS50142724A (en, 2012) | 1975-11-17 |
| PL99139B1 (pl) | 1978-06-30 |
| DK146075A (en, 2012) | 1975-10-07 |
| NL7504057A (nl) | 1975-10-08 |
| LU72207A1 (en, 2012) | 1976-03-02 |
| FR2266692B1 (en, 2012) | 1979-03-09 |
| BE827561A (fr) | 1975-10-06 |
| FR2266692A1 (en, 2012) | 1975-10-31 |
| DD118525A5 (en, 2012) | 1976-03-12 |
| GB1480189A (en) | 1977-07-20 |
| GB1480187A (en) | 1977-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |