GB1480189A - Melting device - Google Patents

Melting device

Info

Publication number
GB1480189A
GB1480189A GB53147/75A GB5314775A GB1480189A GB 1480189 A GB1480189 A GB 1480189A GB 53147/75 A GB53147/75 A GB 53147/75A GB 5314775 A GB5314775 A GB 5314775A GB 1480189 A GB1480189 A GB 1480189A
Authority
GB
United Kingdom
Prior art keywords
heated
screws
phenacetin
housing
april
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB53147/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1480189A publication Critical patent/GB1480189A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/25—Component parts, details or accessories; Auxiliary operations
    • B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
    • B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
    • B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
    • B29C48/402—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders the screws having intermeshing parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
    • B29C48/04—Particle-shaped

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Glanulating (AREA)

Abstract

1480189 Mixing screws BAYER AG 4 April 1975 [6 April 1974] 53147/75 Divided out of 1480187 Heading B1C [Also in Division B5] A melt-spraying device for the production of granules of phenacetin comprises intermeshing self-cleaning screws 3, 4 mounted for rotation in the same direction in a heated housing, the clearance between adjacent parts of the screws and of the housing being 4-30 x 10<SP>-3</SP> times the screw diameter, a spray nozzle, and a heated pump for feeding melt from the heated housing to the spray nozzle. Water or steam are passed through a heating jacket 9 and cooling fluid through a jacket 8 at the inlet 5 to prevent premature melting. The screws 3, 4 may be heated. The heated surfaces may be much hotter than the temperature to which the phenacetin is heated due to the short residence time e.g. at from 150‹ to 303‹C. The molten phenacetin at 140‹C is passed through a line 10 (Fig. 1 not shown) and pumped by a piston pump (11) through a vortex nozzle 12 to be atomised and acidified in air or water at 20‹C.
GB53147/75A 1974-04-06 1975-04-04 Melting device Expired GB1480189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2416904A DE2416904A1 (en) 1974-04-06 1974-04-06 PROCESS FOR MANUFACTURING SPHERICAL PHENACETIN GRAINS AND DEVICE FOR CARRYING OUT THE PROCESS

Publications (1)

Publication Number Publication Date
GB1480189A true GB1480189A (en) 1977-07-20

Family

ID=5912382

Family Applications (2)

Application Number Title Priority Date Filing Date
GB53147/75A Expired GB1480189A (en) 1974-04-06 1975-04-04 Melting device
GB13920/75A Expired GB1480187A (en) 1974-04-06 1975-04-04 Process for the preparation of phenacetin granules

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB13920/75A Expired GB1480187A (en) 1974-04-06 1975-04-04 Process for the preparation of phenacetin granules

Country Status (10)

Country Link
JP (1) JPS50142724A (en)
BE (1) BE827561A (en)
DD (1) DD118525A5 (en)
DE (1) DE2416904A1 (en)
DK (1) DK146075A (en)
FR (1) FR2266692B1 (en)
GB (2) GB1480189A (en)
LU (1) LU72207A1 (en)
NL (1) NL7504057A (en)
PL (1) PL99139B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3833446A1 (en) * 1988-10-01 1990-04-05 Hoechst Ag METHOD FOR THE PRODUCTION OF MEDICAMENT PARTICLES WITH IMPROVED FLUID, STORAGE AND FORMULATION PROPERTIES AND MEDICAMENTS CONTAINING SUCH MEDICAMENT PARTICLES
FR2657257B1 (en) * 1990-01-19 1994-09-02 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF DRUGS IN THE FORM OF PEARLS.

Also Published As

Publication number Publication date
BE827561A (en) 1975-10-06
DE2416904A1 (en) 1975-10-16
FR2266692A1 (en) 1975-10-31
DK146075A (en) 1975-10-07
FR2266692B1 (en) 1979-03-09
GB1480187A (en) 1977-07-20
DD118525A5 (en) 1976-03-12
PL99139B1 (en) 1978-06-30
LU72207A1 (en) 1976-03-02
JPS50142724A (en) 1975-11-17
NL7504057A (en) 1975-10-08

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee