DE2407715C2 - Cephalosporine, Verfahren zu ihrer Herstellung sowie Arzneimittel - Google Patents
Cephalosporine, Verfahren zu ihrer Herstellung sowie ArzneimittelInfo
- Publication number
- DE2407715C2 DE2407715C2 DE2407715A DE2407715A DE2407715C2 DE 2407715 C2 DE2407715 C2 DE 2407715C2 DE 2407715 A DE2407715 A DE 2407715A DE 2407715 A DE2407715 A DE 2407715A DE 2407715 C2 DE2407715 C2 DE 2407715C2
- Authority
- DE
- Germany
- Prior art keywords
- parts
- weight
- oxo
- conh
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 239000001257 hydrogen Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- LLCOIQRNSJBFSN-UHFFFAOYSA-N methane;sulfurochloridic acid Chemical compound C.OS(Cl)(=O)=O LLCOIQRNSJBFSN-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 201000000901 ornithosis Diseases 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- FDJABJJEKWDNQO-UHFFFAOYSA-N pentane;propan-2-one Chemical compound CC(C)=O.CCCCC FDJABJJEKWDNQO-UHFFFAOYSA-N 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- QIQITDHWZYEEPA-UHFFFAOYSA-N thiophene-2-carbonyl chloride Chemical compound ClC(=O)C1=CC=CS1 QIQITDHWZYEEPA-UHFFFAOYSA-N 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2407715A DE2407715C2 (de) | 1974-02-18 | 1974-02-18 | Cephalosporine, Verfahren zu ihrer Herstellung sowie Arzneimittel |
| AR257669A AR207586A1 (es) | 1974-02-18 | 1975-01-01 | Procedimiento para la produccion de nuevas cefalosporinas |
| NO750351A NO750351L (en, 2012) | 1974-02-18 | 1975-02-04 | |
| BG028956A BG26394A3 (bg) | 1974-02-18 | 1975-02-12 | Метод за получаване на цефалоспорини |
| AU78208/75A AU489917B2 (en) | 1974-02-18 | 1975-02-14 | Cephalosporins, process for their preparation and their use as medicaments |
| FI750417A FI750417A7 (en, 2012) | 1974-02-18 | 1975-02-14 | |
| SU2105526A SU544376A3 (ru) | 1974-02-18 | 1975-02-14 | Способ получени производных цефалоспорина или их солей в виде смеси диастереоизомеров или отдельных диастереоизомеров |
| IL7546631A IL46631A0 (en) | 1974-02-18 | 1975-02-14 | New cephalosporins,their preparation and pharmaceutical compositions containing them |
| EG64/75A EG11586A (en) | 1974-02-18 | 1975-02-15 | Cephalosporins,processes for preparation and their use as medicaments |
| PL1975178088A PL98594B1 (pl) | 1974-02-18 | 1975-02-15 | Sposob wytwarzania cefalosporyn |
| JP50018955A JPS50116489A (en, 2012) | 1974-02-18 | 1975-02-17 | |
| ES434797A ES434797A1 (es) | 1974-02-18 | 1975-02-17 | Procedimiento para preparar cefalosporinas. |
| BE153428A BE825623A (fr) | 1974-02-18 | 1975-02-17 | Nouvelles cephalosporines, leur procede de preparation et medicament les contenent |
| SE7501719A SE7501719L (en, 2012) | 1974-02-18 | 1975-02-17 | |
| GB658675A GB1476905A (en) | 1974-02-18 | 1975-02-17 | Cephalosporins processes for their preparation and their use as medicaments |
| ZA00750965A ZA75965B (en) | 1974-02-18 | 1975-02-17 | Cephalosporins, processes for their preparation and their use as medicaments |
| DD184251A DD118649A5 (en, 2012) | 1974-02-18 | 1975-02-17 | |
| LU71860A LU71860A1 (en, 2012) | 1974-02-18 | 1975-02-17 | |
| DK57275*#A DK57275A (en, 2012) | 1974-02-18 | 1975-02-17 | |
| RO197581437A RO66018A (fr) | 1974-02-18 | 1975-02-18 | Procede pour la preparation des cephalosporines |
| AT118975A AT334533B (de) | 1974-02-18 | 1975-02-18 | Verfahren zur herstellung von neuen cephalosporinen |
| FR7505043A FR2261010B1 (en, 2012) | 1974-02-18 | 1975-02-18 | |
| HUBA3208A HU168594B (en, 2012) | 1974-02-18 | 1975-02-18 | |
| NL7501914A NL7501914A (nl) | 1974-02-18 | 1975-02-18 | Werkwijze voor het bereiden van cefalosporinen, alsmede de toepassing daarvan als farmaceutische preparaten. |
| US05/590,794 US4107304A (en) | 1974-02-18 | 1975-06-27 | Oxo-imidazolidine substituted cephalosporins and antibacterial compositions and methods of combatting bacteria employing them |
| US05/685,706 US4086340A (en) | 1974-02-18 | 1976-05-12 | Cephalosporins and their production |
| US05/686,103 US4093722A (en) | 1974-02-18 | 1976-05-13 | Sulfonylimidazolidone substituted cephalosporins, antibacterial compositions containing them, and methods of combatting bacteria employing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2407715A DE2407715C2 (de) | 1974-02-18 | 1974-02-18 | Cephalosporine, Verfahren zu ihrer Herstellung sowie Arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2407715A1 DE2407715A1 (de) | 1975-09-04 |
| DE2407715C2 true DE2407715C2 (de) | 1982-12-02 |
Family
ID=5907728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2407715A Expired DE2407715C2 (de) | 1974-02-18 | 1974-02-18 | Cephalosporine, Verfahren zu ihrer Herstellung sowie Arzneimittel |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS50116489A (en, 2012) |
| AR (1) | AR207586A1 (en, 2012) |
| AT (1) | AT334533B (en, 2012) |
| BE (1) | BE825623A (en, 2012) |
| BG (1) | BG26394A3 (en, 2012) |
| DD (1) | DD118649A5 (en, 2012) |
| DE (1) | DE2407715C2 (en, 2012) |
| DK (1) | DK57275A (en, 2012) |
| EG (1) | EG11586A (en, 2012) |
| ES (1) | ES434797A1 (en, 2012) |
| FI (1) | FI750417A7 (en, 2012) |
| FR (1) | FR2261010B1 (en, 2012) |
| GB (1) | GB1476905A (en, 2012) |
| HU (1) | HU168594B (en, 2012) |
| IL (1) | IL46631A0 (en, 2012) |
| LU (1) | LU71860A1 (en, 2012) |
| NL (1) | NL7501914A (en, 2012) |
| NO (1) | NO750351L (en, 2012) |
| PL (1) | PL98594B1 (en, 2012) |
| RO (1) | RO66018A (en, 2012) |
| SE (1) | SE7501719L (en, 2012) |
| SU (1) | SU544376A3 (en, 2012) |
| ZA (1) | ZA75965B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2525541C2 (de) * | 1975-06-07 | 1984-01-12 | Bayer Ag, 5090 Leverkusen | β-Lactam-Antibiotica, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel |
| DE2528079A1 (de) * | 1975-06-24 | 1977-01-20 | Bayer Ag | Penicilline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| IL49846A (en) * | 1975-06-24 | 1979-07-25 | Bayer Ag | Penicillin and cephalosporin compounds containing an imidazolidinone ring substituted by a carbocycle or heterocycletheir preparation and pharmaceutical compositions comprising them |
| DE2528077A1 (de) * | 1975-06-24 | 1977-01-20 | Bayer Ag | Beta-lactamantibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| FR2362146A1 (fr) * | 1976-08-17 | 1978-03-17 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 7-(n-substitue-2-phenylglycinamido)-3-substitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne |
| DE2658906A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Beta-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS545974A (en) * | 1977-06-16 | 1979-01-17 | Ajinomoto Co Inc | Imidazoledicaroboxylic acid derivatives |
| DE2810083A1 (de) | 1978-03-08 | 1979-09-20 | Bayer Ag | Beta-lactam-verbindungen |
| EP0015240A1 (de) * | 1979-02-16 | 1980-09-03 | Ciba-Geigy Ag | Azacyclyl (thio) ureidoacetyl-Verbindungen und Verfahren zu ihrer Herstellung |
| US4464366A (en) * | 1979-12-19 | 1984-08-07 | Ciba Geigy Corporation | Cephem compounds having a terminal aminocarboxylic acid grouping and containing an azacyclyl(thio)ureido group |
| CN114552015B (zh) * | 2022-02-25 | 2024-04-05 | 珠海市赛纬电子材料股份有限公司 | 电解液添加剂、锂离子电池电解液及锂离子电池 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
| DE2104580C3 (de) * | 1971-02-01 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | Acylureidopenicilline |
| BE786271A (fr) * | 1971-07-17 | 1973-01-15 | Takeda Chemical Industries Ltd | Cephalosporines |
| BE790440A (en, 2012) * | 1971-10-23 | 1973-04-24 | Bayer Ag |
-
1974
- 1974-02-18 DE DE2407715A patent/DE2407715C2/de not_active Expired
-
1975
- 1975-01-01 AR AR257669A patent/AR207586A1/es active
- 1975-02-04 NO NO750351A patent/NO750351L/no unknown
- 1975-02-12 BG BG028956A patent/BG26394A3/xx unknown
- 1975-02-14 IL IL7546631A patent/IL46631A0/xx unknown
- 1975-02-14 FI FI750417A patent/FI750417A7/fi not_active Application Discontinuation
- 1975-02-14 SU SU2105526A patent/SU544376A3/ru active
- 1975-02-15 EG EG64/75A patent/EG11586A/xx active
- 1975-02-15 PL PL1975178088A patent/PL98594B1/pl unknown
- 1975-02-17 JP JP50018955A patent/JPS50116489A/ja active Pending
- 1975-02-17 GB GB658675A patent/GB1476905A/en not_active Expired
- 1975-02-17 ES ES434797A patent/ES434797A1/es not_active Expired
- 1975-02-17 LU LU71860A patent/LU71860A1/xx unknown
- 1975-02-17 DK DK57275*#A patent/DK57275A/da unknown
- 1975-02-17 ZA ZA00750965A patent/ZA75965B/xx unknown
- 1975-02-17 DD DD184251A patent/DD118649A5/xx unknown
- 1975-02-17 SE SE7501719A patent/SE7501719L/xx unknown
- 1975-02-17 BE BE153428A patent/BE825623A/xx unknown
- 1975-02-18 HU HUBA3208A patent/HU168594B/hu unknown
- 1975-02-18 NL NL7501914A patent/NL7501914A/xx not_active Application Discontinuation
- 1975-02-18 FR FR7505043A patent/FR2261010B1/fr not_active Expired
- 1975-02-18 AT AT118975A patent/AT334533B/de not_active IP Right Cessation
- 1975-02-18 RO RO197581437A patent/RO66018A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK57275A (en, 2012) | 1975-10-20 |
| DD118649A5 (en, 2012) | 1976-03-12 |
| BG26394A3 (bg) | 1979-03-15 |
| AR207586A1 (es) | 1976-10-15 |
| IL46631A0 (en) | 1975-04-25 |
| PL98594B1 (pl) | 1978-05-31 |
| GB1476905A (en) | 1977-06-16 |
| SE7501719L (en, 2012) | 1975-08-19 |
| NL7501914A (nl) | 1975-08-20 |
| ZA75965B (en) | 1976-01-28 |
| JPS50116489A (en, 2012) | 1975-09-11 |
| DE2407715A1 (de) | 1975-09-04 |
| ATA118975A (de) | 1976-05-15 |
| FI750417A7 (en, 2012) | 1975-08-19 |
| AU7820875A (en) | 1976-08-19 |
| LU71860A1 (en, 2012) | 1975-12-09 |
| AT334533B (de) | 1976-01-25 |
| FR2261010A1 (en, 2012) | 1975-09-12 |
| RO66018A (fr) | 1980-01-15 |
| BE825623A (fr) | 1975-08-18 |
| SU544376A3 (ru) | 1977-01-25 |
| HU168594B (en, 2012) | 1976-06-28 |
| ES434797A1 (es) | 1977-02-01 |
| EG11586A (en) | 1978-06-30 |
| FR2261010B1 (en, 2012) | 1980-01-11 |
| NO750351L (en, 2012) | 1975-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| D2 | Grant after examination | ||
| 8339 | Ceased/non-payment of the annual fee |