DE2405658A1 - 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE2405658A1
DE2405658A1 DE19742405658 DE2405658A DE2405658A1 DE 2405658 A1 DE2405658 A1 DE 2405658A1 DE 19742405658 DE19742405658 DE 19742405658 DE 2405658 A DE2405658 A DE 2405658A DE 2405658 A1 DE2405658 A1 DE 2405658A1
Authority
DE
Germany
Prior art keywords
group
low molecular
molecular weight
groups
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19742405658
Other languages
German (de)
English (en)
Inventor
Michel Dr Laubie
Georges Remond
Michel Vincent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of DE2405658A1 publication Critical patent/DE2405658A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19742405658 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel Pending DE2405658A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB703773A GB1409865A (en) 1973-02-13 1973-02-13 Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them

Publications (1)

Publication Number Publication Date
DE2405658A1 true DE2405658A1 (de) 1974-08-29

Family

ID=9825435

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19742405658 Pending DE2405658A1 (de) 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE19742462086 Withdrawn DE2462086A1 (de) 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19742462086 Withdrawn DE2462086A1 (de) 1973-02-13 1974-02-06 4-aryl-1,4-dihydropyridine, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Country Status (9)

Country Link
JP (1) JPS5112632B2 (enrdf_load_stackoverflow)
BE (1) BE810921A (enrdf_load_stackoverflow)
CA (1) CA1061346A (enrdf_load_stackoverflow)
DE (2) DE2405658A1 (enrdf_load_stackoverflow)
ES (1) ES423155A1 (enrdf_load_stackoverflow)
FR (1) FR2217016B1 (enrdf_load_stackoverflow)
GB (1) GB1409865A (enrdf_load_stackoverflow)
NL (1) NL7401914A (enrdf_load_stackoverflow)
SU (1) SU575025A3 (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629892A1 (de) * 1975-07-02 1977-01-27 Fujisawa Pharmaceutical Co 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0009206A3 (en) * 1978-09-25 1980-04-16 Bayer Aktiengesellschaft Fluor-containing 1,4-dihydropyridines, process for their preparation and their application in pharmaceuticals
EP0088274A1 (de) * 1982-03-05 1983-09-14 Bayer Ag Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE3529997A1 (de) * 1984-08-22 1986-03-06 Glaxo S.P.A., Verona Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester
DE3628215A1 (de) * 1985-08-21 1987-02-26 Glaxo Spa Heterocyclische verbindungen, verfahren zu ihrer herstellung und pharmazeutische zubereitung
EP0225574A1 (de) * 1985-12-13 1987-06-16 Bayer Ag Neue, fluorhaltige 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE3907508A1 (de) * 1988-03-08 1989-09-21 Egyt Gyogyszervegyeszeti Gyar Verfahren und zwischenprodukte, gegebenenfalls n-substituierte, (2-(nitro)-phenyl)-methylenimine zur herstellung von 1,4-di-(hydro)-2,6-di-(methyl)-4-(2'-(nitro) -phenyl)-pyridin-3,5-di-(carbonsaeure- dimethylester) sowie verfahren zur herstellung dieser zwischenprodukte
EP0411549A1 (en) * 1989-08-02 1991-02-06 Kaken Pharmaceutical Co., Ltd. 1,4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
WO2000005209A1 (en) * 1998-07-23 2000-02-03 Lin, Tong-Ho GUAIACOXYPROPANOLAMINES WITH α/β-ADRENERGIC BLOCKING ACTIVITY

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5046994U (enrdf_load_stackoverflow) * 1973-08-29 1975-05-10
JPS5822679Y2 (ja) * 1980-11-07 1983-05-14 有限会社 米田製作所 面体清掃具
US4458099A (en) * 1981-03-19 1984-07-03 Hitachi, Ltd. Three-phase combined type gas insulated electrical apparatus
JPS60143511A (ja) * 1983-12-29 1985-07-29 スタツクス工業株式会社 マイクロフォンのシールド装置
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
GB8503428D0 (en) * 1985-02-11 1985-03-13 Ici Plc Nitrogen-containing compounds
GB8503429D0 (en) * 1985-02-11 1985-03-13 Ici Plc Chemical compounds
GB8503427D0 (en) * 1985-02-11 1985-03-13 Ici Plc Basic compounds
GB8503424D0 (en) * 1985-02-11 1985-03-13 Ici Plc Heterocyclic derivatives
GB8503426D0 (en) * 1985-02-11 1985-03-13 Ici Plc Pyridine derivatives
GB8503425D0 (en) * 1985-02-11 1985-03-13 Ici Plc Alkanolamine derivatives
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
IT1204459B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
EP0461264A4 (en) * 1989-12-29 1992-02-19 Kaken Pharmaceutical Co., Ltd. Ethynylphenyl derivative, production thereof, and remedy for diseases of circulatory organs containing the same as active ingredient
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
EP2797597B1 (en) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
SI3141542T1 (sl) 2011-12-28 2020-11-30 Global Blood Therapeutics, Inc. Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG11201507349TA (en) 2013-03-15 2015-10-29 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
WO2014150268A1 (en) 2013-03-15 2014-09-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) * 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
ES2860648T5 (es) 2014-02-07 2024-11-27 Global Blood Therapeutics Inc Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1H-pirazol-5-il)piridin-3-il)metoxi)benzaldehído
SG10201912511WA (en) 2015-12-04 2020-02-27 Global Blood Therapeutics Inc Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629892A1 (de) * 1975-07-02 1977-01-27 Fujisawa Pharmaceutical Co 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
EP0009206A3 (en) * 1978-09-25 1980-04-16 Bayer Aktiengesellschaft Fluor-containing 1,4-dihydropyridines, process for their preparation and their application in pharmaceuticals
EP0088274A1 (de) * 1982-03-05 1983-09-14 Bayer Ag Neue 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihrer Verwendung in Arzneimitteln
DE3529997A1 (de) * 1984-08-22 1986-03-06 Glaxo S.P.A., Verona Substituierte 4-phenyl-1,4-dihydropyridincarbonsaeureester
DE3628215A1 (de) * 1985-08-21 1987-02-26 Glaxo Spa Heterocyclische verbindungen, verfahren zu ihrer herstellung und pharmazeutische zubereitung
EP0225574A1 (de) * 1985-12-13 1987-06-16 Bayer Ag Neue, fluorhaltige 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4798840A (en) * 1985-12-13 1989-01-17 Bayer Aktiengesellschaft Coronary-active fluorine-containing 1,4-dihydropyridines
DE3907508A1 (de) * 1988-03-08 1989-09-21 Egyt Gyogyszervegyeszeti Gyar Verfahren und zwischenprodukte, gegebenenfalls n-substituierte, (2-(nitro)-phenyl)-methylenimine zur herstellung von 1,4-di-(hydro)-2,6-di-(methyl)-4-(2'-(nitro) -phenyl)-pyridin-3,5-di-(carbonsaeure- dimethylester) sowie verfahren zur herstellung dieser zwischenprodukte
EP0411549A1 (en) * 1989-08-02 1991-02-06 Kaken Pharmaceutical Co., Ltd. 1,4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
US5158963A (en) * 1989-08-02 1992-10-27 Kaken Pharmaceutical Co., Ltd. 1-4-dihydropyridine derivative, process for preparing the same and pharmaceutical composition containing the same
WO2000005209A1 (en) * 1998-07-23 2000-02-03 Lin, Tong-Ho GUAIACOXYPROPANOLAMINES WITH α/β-ADRENERGIC BLOCKING ACTIVITY

Also Published As

Publication number Publication date
FR2217016A1 (enrdf_load_stackoverflow) 1974-09-06
DE2462086A1 (de) 1975-10-23
FR2217016B1 (enrdf_load_stackoverflow) 1977-07-01
ES423155A1 (es) 1976-10-16
GB1409865A (en) 1975-10-15
NL7401914A (enrdf_load_stackoverflow) 1974-08-15
CA1061346A (fr) 1979-08-28
BE810921A (fr) 1974-08-12
JPS5112632B2 (enrdf_load_stackoverflow) 1976-04-21
SU575025A3 (ru) 1977-09-30
JPS5040576A (enrdf_load_stackoverflow) 1975-04-14

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