DE2405593A1 - Verfahren zur verminderung der nucleinsaeuremenge in proteinmaterial - Google Patents
Verfahren zur verminderung der nucleinsaeuremenge in proteinmaterialInfo
- Publication number
- DE2405593A1 DE2405593A1 DE19742405593 DE2405593A DE2405593A1 DE 2405593 A1 DE2405593 A1 DE 2405593A1 DE 19742405593 DE19742405593 DE 19742405593 DE 2405593 A DE2405593 A DE 2405593A DE 2405593 A1 DE2405593 A1 DE 2405593A1
- Authority
- DE
- Germany
- Prior art keywords
- process according
- treated
- protein
- water
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000463 material Substances 0.000 title claims description 46
- 108020004707 nucleic acids Proteins 0.000 title claims description 42
- 102000039446 nucleic acids Human genes 0.000 title claims description 42
- 150000007523 nucleic acids Chemical class 0.000 title claims description 42
- 102000004169 proteins and genes Human genes 0.000 title claims description 41
- 108090000623 proteins and genes Proteins 0.000 title claims description 40
- 238000000034 method Methods 0.000 title claims description 39
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 239000003513 alkali Substances 0.000 claims description 26
- 239000002904 solvent Substances 0.000 claims description 24
- 244000005700 microbiome Species 0.000 claims description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 14
- 229930195733 hydrocarbon Natural products 0.000 claims description 13
- 150000002430 hydrocarbons Chemical class 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 239000003960 organic solvent Substances 0.000 claims description 9
- 239000007789 gas Substances 0.000 claims description 8
- 150000001298 alcohols Chemical class 0.000 claims description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 239000011343 solid material Substances 0.000 claims description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 3
- 241000235015 Yarrowia lipolytica Species 0.000 claims description 3
- 239000000908 ammonium hydroxide Substances 0.000 claims description 3
- 241000222178 Candida tropicalis Species 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 1
- 150000002896 organic halogen compounds Chemical class 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 31
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 13
- 239000007787 solid Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 4
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 229940116269 uric acid Drugs 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000012223 aqueous fraction Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000001223 reverse osmosis Methods 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010058643 Fungal Proteins Proteins 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000556720 Manga Species 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 108010092464 Urate Oxidase Proteins 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000010779 crude oil Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/08—Reducing the nucleic acid content
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/20—Proteins from microorganisms or unicellular algae
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/23—Removal of unwanted matter, e.g. deodorisation or detoxification by extraction with solvents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/276—Treatment with inorganic compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB621373A GB1400691A (en) | 1973-02-08 | 1973-02-08 | Process for the production of proteinaceous material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2405593A1 true DE2405593A1 (de) | 1974-08-15 |
Family
ID=9810482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19742405593 Withdrawn DE2405593A1 (de) | 1973-02-08 | 1974-02-06 | Verfahren zur verminderung der nucleinsaeuremenge in proteinmaterial |
Country Status (7)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2633666A1 (de) * | 1976-07-27 | 1978-02-02 | Hoechst Ag | Verfahren zur verminderung des lipid- und nucleinsaeure-gehaltes in mikrobiellen zellmassen |
| DE2748885A1 (de) * | 1977-11-02 | 1979-05-03 | Hoechst Ag | Verfahren zur verbesserung der eigenschaften von schroten oder mehlen aus oelsaaten |
| EP0017956A1 (de) * | 1979-04-19 | 1980-10-29 | Hoechst Aktiengesellschaft | Verfahren zur Entfernung von lipoiden und wasserlöslichen Verbindungen aus Rohproteinen tierischen Ursprungs |
| EP0018534A1 (de) * | 1979-04-19 | 1980-11-12 | Hoechst Aktiengesellschaft | Verfahren zur Verbesserung der Eigenschaften von Schroten oder Mehlen aus Ölsaaten |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206243A (en) | 1976-07-27 | 1980-06-03 | Hoechst Aktiengesellschaft | Process for reducing the contents of lipids and nucleic acid in microbial cell masses |
| EP0041650A3 (en) * | 1980-06-10 | 1982-05-12 | Provesta Corporation | A method of reducing the nucleic acid level in single cell protein and method for producing a single cell protein product |
-
1973
- 1973-02-08 GB GB621373A patent/GB1400691A/en not_active Expired
-
1974
- 1974-02-06 IT IT7448175A patent/IT1056079B/it active
- 1974-02-06 NL NL7401632A patent/NL7401632A/xx not_active Application Discontinuation
- 1974-02-06 DE DE19742405593 patent/DE2405593A1/de not_active Withdrawn
- 1974-02-07 FR FR7404180A patent/FR2216928B1/fr not_active Expired
- 1974-02-07 ES ES423262A patent/ES423262A1/es not_active Expired
- 1974-02-08 BE BE140703A patent/BE810786A/xx unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2633666A1 (de) * | 1976-07-27 | 1978-02-02 | Hoechst Ag | Verfahren zur verminderung des lipid- und nucleinsaeure-gehaltes in mikrobiellen zellmassen |
| DE2748885A1 (de) * | 1977-11-02 | 1979-05-03 | Hoechst Ag | Verfahren zur verbesserung der eigenschaften von schroten oder mehlen aus oelsaaten |
| EP0017956A1 (de) * | 1979-04-19 | 1980-10-29 | Hoechst Aktiengesellschaft | Verfahren zur Entfernung von lipoiden und wasserlöslichen Verbindungen aus Rohproteinen tierischen Ursprungs |
| EP0018534A1 (de) * | 1979-04-19 | 1980-11-12 | Hoechst Aktiengesellschaft | Verfahren zur Verbesserung der Eigenschaften von Schroten oder Mehlen aus Ölsaaten |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2216928A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-09-06 |
| IT1056079B (it) | 1982-01-30 |
| BE810786A (fr) | 1974-08-08 |
| GB1400691A (en) | 1975-07-23 |
| NL7401632A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-12 |
| ES423262A1 (es) | 1976-05-01 |
| FR2216928B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee | ||
| 8141 | Disposal/no request for examination |