DE2348176A1 - Arzneimittel zur erniedrigung des blutcholesterinspiegels - Google Patents
Arzneimittel zur erniedrigung des blutcholesterinspiegelsInfo
- Publication number
- DE2348176A1 DE2348176A1 DE19732348176 DE2348176A DE2348176A1 DE 2348176 A1 DE2348176 A1 DE 2348176A1 DE 19732348176 DE19732348176 DE 19732348176 DE 2348176 A DE2348176 A DE 2348176A DE 2348176 A1 DE2348176 A1 DE 2348176A1
- Authority
- DE
- Germany
- Prior art keywords
- cholesterol
- diosgenin
- formula
- spirostan
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims description 109
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- 239000008280 blood Substances 0.000 title claims description 6
- 229940126601 medicinal product Drugs 0.000 title 1
- WQLVFSAGQJTQCK-VKROHFNGSA-N diosgenin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)CC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 WQLVFSAGQJTQCK-VKROHFNGSA-N 0.000 claims description 33
- DWCSNWXARWMZTG-UHFFFAOYSA-N Trigonegenin A Natural products CC1C(C2(CCC3C4(C)CCC(O)C=C4CCC3C2C2)C)C2OC11CCC(C)CO1 DWCSNWXARWMZTG-UHFFFAOYSA-N 0.000 claims description 32
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 claims description 32
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 claims description 17
- 229960001214 clofibrate Drugs 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
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- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 5
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- 239000000375 suspending agent Substances 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003700 epoxy group Chemical group 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
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- FVFFOZVQDWVGCD-RAZYJPRQSA-N (1S,2S,4S,6R,7S,8R,9S,12S,13R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane] Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CCCCC4=CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CCC(C)CO1 FVFFOZVQDWVGCD-RAZYJPRQSA-N 0.000 description 4
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- CZCROZIJKBXZDP-OCGSZLBCSA-N C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)OC(C)=O)O[C@]11CCC(C)CO1 Chemical compound C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)OC(C)=O)O[C@]11CCC(C)CO1 CZCROZIJKBXZDP-OCGSZLBCSA-N 0.000 description 3
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- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
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- ZQWYUWMVMXZCNA-UHFFFAOYSA-N ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(OC)C=C1 ZQWYUWMVMXZCNA-UHFFFAOYSA-N 0.000 description 2
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- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
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- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229930193551 sterin Natural products 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- CZCROZIJKBXZDP-UHFFFAOYSA-N yamogenin acetate Natural products CC1C(C2(CCC3C4(C)CCC(CC4=CCC3C2C2)OC(C)=O)C)C2OC11CCC(C)CO1 CZCROZIJKBXZDP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA153,515A CA985172A (en) | 1972-10-06 | 1972-10-06 | Compositions and methods for reducing blood cholesterol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2348176A1 true DE2348176A1 (de) | 1974-04-11 |
Family
ID=4094630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732348176 Pending DE2348176A1 (de) | 1972-10-06 | 1973-09-25 | Arzneimittel zur erniedrigung des blutcholesterinspiegels |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3890438A (OSRAM) |
| AU (1) | AU477269B2 (OSRAM) |
| BE (1) | BE805634A (OSRAM) |
| CA (1) | CA985172A (OSRAM) |
| CS (1) | CS197387B1 (OSRAM) |
| DD (1) | DD106948A5 (OSRAM) |
| DE (1) | DE2348176A1 (OSRAM) |
| ES (1) | ES419355A1 (OSRAM) |
| FR (1) | FR2201893B1 (OSRAM) |
| GB (1) | GB1439625A (OSRAM) |
| HU (1) | HU169814B (OSRAM) |
| IE (1) | IE38274B1 (OSRAM) |
| IN (1) | IN138921B (OSRAM) |
| NL (1) | NL7313519A (OSRAM) |
| SE (1) | SE403886B (OSRAM) |
| ZA (1) | ZA737246B (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3838716A1 (de) * | 1988-11-15 | 1990-05-17 | Kanoldt Arzneimittel Gmbh | Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie |
| US6929807B1 (en) * | 1996-08-09 | 2005-08-16 | Mannatech, Inc. | Compositions of plant carbohydrates as dietary supplements |
| GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| US20030118673A1 (en) * | 1998-03-26 | 2003-06-26 | Zongqin Xia | Smilagenin and anzurogenin-D for the treatment of alzheimer's disease |
| PT1066042E (pt) * | 1998-03-26 | 2006-12-29 | Phytopharm Plc | Saponinas esteroides para o tratamento de doença de alzheimer |
| GB2347676A (en) * | 1999-03-08 | 2000-09-13 | Phytopharm Plc | Screening method |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
| GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
| WO2003022287A1 (fr) * | 2001-08-24 | 2003-03-20 | Jilin Tianyao Science And Technology Co. Ltd. | UTILISATION DE 3β-HYDROXY-5-SPIROSTENE POUR PREVENIR OU TRAITER DES MALADIES OU DES ETATS CARDIO-VASCULAIRES, INHIBER DES TUMEURS ET REDUIRE LES LIPIDES SANGUINS |
| CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
| US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
| WO2003086411A1 (fr) * | 2002-04-15 | 2003-10-23 | Chengdu Di'ao Pharmaceutical Group Co., Ltd. | Composes et techniques de preparation de carboxylate de diosgenine et d'un derive de succinate monoester de diosgenine |
| GB0409567D0 (en) | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
| US20090208588A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | GERD carbohydrate compositions |
| US20090209486A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions of carbohydrates as dietary supplements |
| US20090209488A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of exercise induced asthma |
| US20090209489A1 (en) * | 2008-02-19 | 2009-08-20 | Roger Wayne Brown | Compositions for the treatment of diabetis, system PH disorders, high blood pressure, and a cancer marker system |
| EP2595621A1 (en) | 2010-07-20 | 2013-05-29 | Phytopharm PLC | Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders |
| FR3133158A1 (fr) | 2022-03-04 | 2023-09-08 | Psa Automobiles Sa | Procédé de gestion énergetique d’une prise d’alimentation d’accessoire dans un véhicule automobile à l’arrêt |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE630211A (OSRAM) * | 1962-03-28 |
-
1972
- 1972-10-06 CA CA153,515A patent/CA985172A/en not_active Expired
-
1973
- 1973-09-11 ZA ZA00737246A patent/ZA737246B/xx unknown
- 1973-09-17 US US398130A patent/US3890438A/en not_active Expired - Lifetime
- 1973-09-24 IE IE1698/73A patent/IE38274B1/xx unknown
- 1973-09-25 DE DE19732348176 patent/DE2348176A1/de active Pending
- 1973-10-01 IN IN2210/CAL/73A patent/IN138921B/en unknown
- 1973-10-02 NL NL7313519A patent/NL7313519A/xx not_active Application Discontinuation
- 1973-10-03 BE BE136318A patent/BE805634A/xx unknown
- 1973-10-04 HU HUAE394A patent/HU169814B/hu unknown
- 1973-10-05 DD DD173898A patent/DD106948A5/xx unknown
- 1973-10-05 CS CS736877A patent/CS197387B1/cs unknown
- 1973-10-05 GB GB4656473A patent/GB1439625A/en not_active Expired
- 1973-10-05 FR FR7335748A patent/FR2201893B1/fr not_active Expired
- 1973-10-05 ES ES419355A patent/ES419355A1/es not_active Expired
- 1973-10-05 SE SE7313618A patent/SE403886B/xx unknown
- 1973-10-08 AU AU61108/73A patent/AU477269B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU477269B2 (en) | 1976-10-21 |
| HU169814B (OSRAM) | 1977-02-28 |
| IE38274L (en) | 1974-04-06 |
| SE403886B (sv) | 1978-09-11 |
| AU6110873A (en) | 1975-04-10 |
| US3890438A (en) | 1975-06-17 |
| FR2201893A1 (OSRAM) | 1974-05-03 |
| DD106948A5 (OSRAM) | 1974-07-12 |
| NL7313519A (OSRAM) | 1974-04-09 |
| ZA737246B (en) | 1975-04-30 |
| BE805634A (fr) | 1974-04-03 |
| IE38274B1 (en) | 1978-02-01 |
| CS197387B1 (en) | 1980-05-30 |
| ES419355A1 (es) | 1976-03-01 |
| FR2201893B1 (OSRAM) | 1977-09-09 |
| CA985172A (en) | 1976-03-09 |
| IN138921B (OSRAM) | 1976-04-17 |
| GB1439625A (en) | 1976-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHA | Expiration of time for request for examination |