DE2335466A1 - Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel - Google Patents
Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittelInfo
- Publication number
- DE2335466A1 DE2335466A1 DE19732335466 DE2335466A DE2335466A1 DE 2335466 A1 DE2335466 A1 DE 2335466A1 DE 19732335466 DE19732335466 DE 19732335466 DE 2335466 A DE2335466 A DE 2335466A DE 2335466 A1 DE2335466 A1 DE 2335466A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- formula
- ester
- salts
- given above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19732335466 DE2335466A1 (de) | 1973-07-12 | 1973-07-12 | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
CA204,204A CA1025450A (en) | 1973-07-12 | 1974-07-05 | 1,4-dihydropyridine esters |
AU70969/74A AU477107B2 (en) | 1973-07-12 | 1974-07-08 | New alkoxyalkyl-1. 4-dihydropyridines their preparation, and their medicinal use |
AT569674A AT337699B (de) | 1973-07-12 | 1974-07-10 | Verfahren zur herstellung von neuen alkoxyalkyl-1,4-dihydropyridinestern und ihren salzen |
LU70498A LU70498A1 (no) | 1973-07-12 | 1974-07-10 | |
JP49078370A JPS6011030B2 (ja) | 1973-07-12 | 1974-07-10 | アルコキシアルキル1,4−ジヒドロピリジンエステルまたはその塩の製造方法 |
NL7409344A NL7409344A (nl) | 1973-07-12 | 1974-07-10 | Werkwijze voor het bereiden van alkoxyalkyl 1.4-dihydropyridinen, alsmede de toepassing daarvan als farmaceutische preparaten. |
FI2120/74A FI212074A (no) | 1973-07-12 | 1974-07-10 | |
PL1974183228A PL91873B1 (no) | 1973-07-12 | 1974-07-10 | |
IL45233A IL45233A (en) | 1973-07-12 | 1974-07-10 | Alkoxyalkyl-1,4-dihydropyridine-3,5-dicarboxylic acid diester derivatives,their preparation and pharmaceutical compositions containing them |
DD179837A DD118631A5 (no) | 1973-07-12 | 1974-07-10 | |
PL1974172611A PL94266B1 (no) | 1973-07-12 | 1974-07-10 | |
SE7409146A SE7409146L (sv) | 1973-07-12 | 1974-07-11 | Alkoxialkyl-1,4-dihydropyridiner till anvendning som lekemedel och sett for deras framstellning. |
GB3074674A GB1436289A (en) | 1973-07-12 | 1974-07-11 | Alkoxyalkyl-1,4-dihydropyridines their preparation and their medicinal use |
DK373974A DK373974A (no) | 1973-07-12 | 1974-07-11 | |
HU74BA00003114A HU171401B (hu) | 1973-07-12 | 1974-07-11 | Sposob poluchenija proizvodnykh 2-alkoksial'kil-1,4-digidropiridina |
CH960374A CH614196A5 (en) | 1973-07-12 | 1974-07-11 | Process for the preparation of alkoxyalkyl-1,4-dihydropyridines |
BE146464A BE817540A (fr) | 1973-07-12 | 1974-07-11 | Nouveaux esters d'alkoxyalkyl-1 |
ZA00744461A ZA744461B (en) | 1973-07-12 | 1974-07-11 | New alkoxyalkyl-1,4-dihydropyridines, their preparation and their medicinal use |
ES428185A ES428185A1 (es) | 1973-07-12 | 1974-07-11 | Procedimiento para la obtencion de esteres de alcoxialquil-hidropiridinas. |
IE1466/74A IE39602B1 (en) | 1973-07-12 | 1974-07-11 | New alkoxyalkyl-1,4-dihydropyridines, their preparation, and their medicinal use |
FR7424425A FR2236497B1 (no) | 1973-07-12 | 1974-07-12 | |
US05/576,724 US3974278A (en) | 1973-07-12 | 1975-05-12 | 1,4-Dihydropyridine esters |
ES448396A ES448396A1 (es) | 1973-07-12 | 1975-05-31 | Procedimiento para la obtencion de esteres de alcoxialquil- hidropiridinas. |
ES448395A ES448395A1 (es) | 1973-07-12 | 1975-05-31 | Procedimiento para la obtencion de esteres de alcoxialquil- hidropiridinas. |
US05/585,963 US4020178A (en) | 1973-07-12 | 1975-06-11 | 1,4-Dihydropyridine esters used as coronary dilators and anti-hypertensives |
US05/609,153 US3971796A (en) | 1973-07-12 | 1975-08-29 | 1,4-Dihydropyridine esters |
ES448394A ES448394A1 (es) | 1973-07-12 | 1976-05-31 | Procedimiento para la obtencion de esteres de alcoxialquil- hidropiridina. |
ES448397A ES448397A1 (es) | 1973-07-12 | 1976-05-31 | Procedimiento para la obtencion de esteres de alcoxialquil- hidropiridinas. |
CH1241077A CH622507A5 (en) | 1973-07-12 | 1977-10-11 | Process for the preparation of 1,4-dihydropyridines |
JP57000455A JPS5943952B2 (ja) | 1973-07-12 | 1982-01-06 | アルコキシアルキル−1,4−ジヒドロピリジンエステルまたはその塩の製造方法 |
JP57000454A JPS5943951B2 (ja) | 1973-07-12 | 1982-01-06 | アルコキシアルキル−1,4−ジヒドロピリジンエステルまたはその塩の製造法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19732335466 DE2335466A1 (de) | 1973-07-12 | 1973-07-12 | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2335466A1 true DE2335466A1 (de) | 1975-01-30 |
Family
ID=5886689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19732335466 Withdrawn DE2335466A1 (de) | 1973-07-12 | 1973-07-12 | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Country Status (21)
Country | Link |
---|---|
JP (3) | JPS6011030B2 (no) |
AT (1) | AT337699B (no) |
AU (1) | AU477107B2 (no) |
BE (1) | BE817540A (no) |
CA (1) | CA1025450A (no) |
CH (2) | CH614196A5 (no) |
DD (1) | DD118631A5 (no) |
DE (1) | DE2335466A1 (no) |
DK (1) | DK373974A (no) |
ES (5) | ES428185A1 (no) |
FI (1) | FI212074A (no) |
FR (1) | FR2236497B1 (no) |
GB (1) | GB1436289A (no) |
HU (1) | HU171401B (no) |
IE (1) | IE39602B1 (no) |
IL (1) | IL45233A (no) |
LU (1) | LU70498A1 (no) |
NL (1) | NL7409344A (no) |
PL (2) | PL91873B1 (no) |
SE (1) | SE7409146L (no) |
ZA (1) | ZA744461B (no) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2756226A1 (de) * | 1976-12-17 | 1978-06-29 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel |
EP0124743A2 (de) * | 1983-04-05 | 1984-11-14 | Bayer Ag | Verfahren zur Herstellung von unsymmetrischen 1,4-Di-hydropyridindicarbonsäureestern |
EP0124742A2 (de) * | 1983-04-05 | 1984-11-14 | Bayer Ag | Verfahren zur Herstellung von symmetrischen 1,4-Dihydropyridindicarbonsäureestern |
EP0173943A1 (de) * | 1984-09-05 | 1986-03-12 | Bayer Ag | Neue Pyridylethyl-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
WO1986002836A1 (en) * | 1984-11-12 | 1986-05-22 | Sandoz Ag | New use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
FR2672890A1 (fr) * | 1991-02-20 | 1992-08-21 | Inst Investigacion Desarrol | Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres. |
AT395586B (de) * | 1988-03-08 | 1993-01-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT399872B (de) * | 1988-03-08 | 1995-08-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT399873B (de) * | 1988-03-08 | 1995-08-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT400241B (de) * | 1988-03-08 | 1995-11-27 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
JPS53146941U (no) * | 1977-04-26 | 1978-11-18 | ||
DE3222367A1 (de) * | 1982-06-15 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung |
US4678796A (en) * | 1984-11-30 | 1987-07-07 | Warner-Lambert Company | 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
FI862343A (fi) | 1985-06-17 | 1986-12-18 | Warner Lambert Co | Foerfarande foer framstaellning av terapeutiskt verkande 1,4-dihydropyridinfoereningar. |
US4732898A (en) * | 1986-04-29 | 1988-03-22 | Warner-Lambert Company | 2-(2-aryl-2-oxoalkylidene) analogs of-3,5-pyridinedicarboxylic acid dialkyl esters useful for treatment of cardiovascular disorders |
JPS6378289A (ja) * | 1986-09-20 | 1988-04-08 | 株式会社富士通ゼネラル | 車両の台数検出装置 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
-
1973
- 1973-07-12 DE DE19732335466 patent/DE2335466A1/de not_active Withdrawn
-
1974
- 1974-07-05 CA CA204,204A patent/CA1025450A/en not_active Expired
- 1974-07-08 AU AU70969/74A patent/AU477107B2/en not_active Expired
- 1974-07-10 DD DD179837A patent/DD118631A5/xx unknown
- 1974-07-10 JP JP49078370A patent/JPS6011030B2/ja not_active Expired
- 1974-07-10 PL PL1974183228A patent/PL91873B1/pl unknown
- 1974-07-10 FI FI2120/74A patent/FI212074A/fi unknown
- 1974-07-10 PL PL1974172611A patent/PL94266B1/pl unknown
- 1974-07-10 IL IL45233A patent/IL45233A/xx unknown
- 1974-07-10 LU LU70498A patent/LU70498A1/xx unknown
- 1974-07-10 AT AT569674A patent/AT337699B/de not_active IP Right Cessation
- 1974-07-10 NL NL7409344A patent/NL7409344A/xx not_active Application Discontinuation
- 1974-07-11 ES ES428185A patent/ES428185A1/es not_active Expired
- 1974-07-11 DK DK373974A patent/DK373974A/da unknown
- 1974-07-11 SE SE7409146A patent/SE7409146L/xx unknown
- 1974-07-11 GB GB3074674A patent/GB1436289A/en not_active Expired
- 1974-07-11 HU HU74BA00003114A patent/HU171401B/hu unknown
- 1974-07-11 BE BE146464A patent/BE817540A/xx unknown
- 1974-07-11 ZA ZA00744461A patent/ZA744461B/xx unknown
- 1974-07-11 IE IE1466/74A patent/IE39602B1/xx unknown
- 1974-07-11 CH CH960374A patent/CH614196A5/xx not_active IP Right Cessation
- 1974-07-12 FR FR7424425A patent/FR2236497B1/fr not_active Expired
-
1975
- 1975-05-31 ES ES448395A patent/ES448395A1/es not_active Expired
- 1975-05-31 ES ES448396A patent/ES448396A1/es not_active Expired
-
1976
- 1976-05-31 ES ES448397A patent/ES448397A1/es not_active Expired
- 1976-05-31 ES ES448394A patent/ES448394A1/es not_active Expired
-
1977
- 1977-10-11 CH CH1241077A patent/CH622507A5/de not_active IP Right Cessation
-
1982
- 1982-01-06 JP JP57000455A patent/JPS5943952B2/ja not_active Expired
- 1982-01-06 JP JP57000454A patent/JPS5943951B2/ja not_active Expired
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2756226A1 (de) * | 1976-12-17 | 1978-06-29 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridin-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel |
EP0124743A3 (en) * | 1983-04-05 | 1987-05-20 | Bayer Ag | Process for the preparation of asymmetric 1,4-dihydropyridine-carboxylic acid esters |
EP0124743A2 (de) * | 1983-04-05 | 1984-11-14 | Bayer Ag | Verfahren zur Herstellung von unsymmetrischen 1,4-Di-hydropyridindicarbonsäureestern |
EP0124742A2 (de) * | 1983-04-05 | 1984-11-14 | Bayer Ag | Verfahren zur Herstellung von symmetrischen 1,4-Dihydropyridindicarbonsäureestern |
EP0124742A3 (en) * | 1983-04-05 | 1987-05-27 | Bayer Ag | Process for the preparation of symmetric 1,4-dihydropyridine-carboxylic esters |
EP0173943A1 (de) * | 1984-09-05 | 1986-03-12 | Bayer Ag | Neue Pyridylethyl-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
WO1986002836A1 (en) * | 1984-11-12 | 1986-05-22 | Sandoz Ag | New use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
AT395586B (de) * | 1988-03-08 | 1993-01-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT399872B (de) * | 1988-03-08 | 1995-08-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT399873B (de) * | 1988-03-08 | 1995-08-25 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
AT400241B (de) * | 1988-03-08 | 1995-11-27 | Egyt Gyogyszervegyeszeti Gyar | Verfahren zur herstellung eines 1,4-dihydro-pyridin-derivates |
FR2672890A1 (fr) * | 1991-02-20 | 1992-08-21 | Inst Investigacion Desarrol | Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres. |
EP0500426A1 (fr) * | 1991-02-20 | 1992-08-26 | Instituto de Investigacion Y Desarrollo Quimico-Biologico S.A. | Dérivés de 2,6-diméthyl-4-(4'-hydroxy-3',5'-di-t-butylphényl)-1,4-dihydropyridine, leur procédé de préparation et leur utilisation comme capteurs de radicaux libres |
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