DE2308037A1 - Verfahren zur herstellung eines antiserums zur serologischen identifizierung von pathogenen arten von candida - Google Patents
Verfahren zur herstellung eines antiserums zur serologischen identifizierung von pathogenen arten von candidaInfo
- Publication number
- DE2308037A1 DE2308037A1 DE19732308037 DE2308037A DE2308037A1 DE 2308037 A1 DE2308037 A1 DE 2308037A1 DE 19732308037 DE19732308037 DE 19732308037 DE 2308037 A DE2308037 A DE 2308037A DE 2308037 A1 DE2308037 A1 DE 2308037A1
- Authority
- DE
- Germany
- Prior art keywords
- antiserum
- yeast
- candida
- antigen
- mannan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 25
- 241000222120 Candida <Saccharomycetales> Species 0.000 title claims description 10
- 230000000405 serological effect Effects 0.000 title claims description 7
- 244000052769 pathogen Species 0.000 title claims description 6
- 241000222122 Candida albicans Species 0.000 claims description 31
- 229920000057 Mannan Polymers 0.000 claims description 31
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 30
- 239000000427 antigen Substances 0.000 claims description 30
- 102000036639 antigens Human genes 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- 102000006395 Globulins Human genes 0.000 claims description 17
- 108010044091 Globulins Proteins 0.000 claims description 17
- 241000235645 Pichia kudriavzevii Species 0.000 claims description 10
- 241001465754 Metazoa Species 0.000 claims description 9
- 229940095731 candida albicans Drugs 0.000 claims description 9
- 241000222178 Candida tropicalis Species 0.000 claims description 8
- 241000235048 Meyerozyma guilliermondii Species 0.000 claims description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 7
- 230000000890 antigenic effect Effects 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 210000002421 cell wall Anatomy 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 claims description 3
- 241001123676 Metschnikowia pulcherrima Species 0.000 claims description 3
- 241000521553 Pichia fermentans Species 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- LSTRKXWIZZZYAS-UHFFFAOYSA-N 2-bromoacetyl bromide Chemical compound BrCC(Br)=O LSTRKXWIZZZYAS-UHFFFAOYSA-N 0.000 claims description 2
- 108010049003 Fibrinogen Proteins 0.000 claims description 2
- 102000008946 Fibrinogen Human genes 0.000 claims description 2
- 210000000601 blood cell Anatomy 0.000 claims description 2
- 229940012952 fibrinogen Drugs 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000003918 triazines Chemical class 0.000 claims description 2
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 20
- 210000002966 serum Anatomy 0.000 description 14
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 101710186708 Agglutinin Proteins 0.000 description 11
- 101710146024 Horcolin Proteins 0.000 description 11
- 101710189395 Lectin Proteins 0.000 description 11
- 101710179758 Mannose-specific lectin Proteins 0.000 description 11
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 11
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 11
- 239000000910 agglutinin Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 230000009102 absorption Effects 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 9
- 210000005253 yeast cell Anatomy 0.000 description 8
- 244000285963 Kluyveromyces fragilis Species 0.000 description 6
- 241000222126 [Candida] glabrata Species 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 241000235646 Cyberlindnera jadinii Species 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 241000878745 Cyberlindnera saturnus Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 241000589220 Acetobacter Species 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000201990 Andira aubletii Species 0.000 description 1
- 244000206911 Candida holmii Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 241000222173 Candida parapsilosis Species 0.000 description 1
- 241001123652 Candida versatilis Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000144253 Crepidotus antillarum Species 0.000 description 1
- 241001007293 Curvularia catenulata Species 0.000 description 1
- 241001489196 Cyberlindnera bimundalis Species 0.000 description 1
- 241001489166 Cyberlindnera fabianii Species 0.000 description 1
- 241000480081 Cytospora intermedia Species 0.000 description 1
- 241001123230 Debaryomyces coudertii Species 0.000 description 1
- 241000235036 Debaryomyces hansenii Species 0.000 description 1
- 241001123229 Debaryomyces maramus Species 0.000 description 1
- 241001043481 Debaryomyces subglobosus Species 0.000 description 1
- 241001465310 Eremothecium coryli Species 0.000 description 1
- 244000042139 Eria javanica Species 0.000 description 1
- 244000187717 Eucalyptus intermedia Species 0.000 description 1
- 102220530479 F-box only protein 3_I96S_mutation Human genes 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 108010074864 Factor XI Proteins 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 241000410074 Festuca ovina Species 0.000 description 1
- 210000000712 G cell Anatomy 0.000 description 1
- 241000652008 Geobacillus tropicalis Species 0.000 description 1
- 241000233600 Glycine albicans Species 0.000 description 1
- 244000286779 Hansenula anomala Species 0.000 description 1
- 241001346126 Hebeloma matritense Species 0.000 description 1
- 241000291719 Hoplocampa minuta Species 0.000 description 1
- 244000014603 Kigelia pinnata Species 0.000 description 1
- 244000018606 Korthalsella japonica Species 0.000 description 1
- 241001661539 Kregervanrija fluxuum Species 0.000 description 1
- 241001304302 Kuraishia capsulata Species 0.000 description 1
- 241001123675 Metschnikowia reukaufii Species 0.000 description 1
- 241000320412 Ogataea angusta Species 0.000 description 1
- 241000572479 Ophiorrhiza rugosa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000235062 Pichia membranifaciens Species 0.000 description 1
- 241000531871 Pichia terricola Species 0.000 description 1
- 235000005205 Pinus Nutrition 0.000 description 1
- 241000218602 Pinus <genus> Species 0.000 description 1
- 241000866625 Polymorphus Species 0.000 description 1
- 241000241446 Propolis farinosa Species 0.000 description 1
- 240000004604 Ptychosperma elegans Species 0.000 description 1
- 241001417893 Robynsia glabrata Species 0.000 description 1
- 241000235072 Saccharomyces bayanus Species 0.000 description 1
- 244000206963 Saccharomyces cerevisiae var. diastaticus Species 0.000 description 1
- 241001123227 Saccharomyces pastorianus Species 0.000 description 1
- 241000582914 Saccharomyces uvarum Species 0.000 description 1
- 240000003114 Salix fragilis Species 0.000 description 1
- 241001123231 Schwanniomyces capriottii Species 0.000 description 1
- 240000003377 Shepherdia canadensis Species 0.000 description 1
- 244000041365 Streblochaete longiarista Species 0.000 description 1
- 241000253697 Tabernaemontana inconspicua Species 0.000 description 1
- 241000008919 Tammsia anomala Species 0.000 description 1
- 240000001449 Tephrosia candida Species 0.000 description 1
- 241000911206 Thelephora versatilis Species 0.000 description 1
- 241001180714 Thompsonella colliculosa Species 0.000 description 1
- 244000288561 Torulaspora delbrueckii Species 0.000 description 1
- 241000229115 Torulaspora globosa Species 0.000 description 1
- 240000002438 Trichosanthes globosa Species 0.000 description 1
- 241001452678 Wickerhamomyces canadensis Species 0.000 description 1
- 241001489164 Wickerhamomyces silvicola Species 0.000 description 1
- 241001193070 Wickerhamomyces subpelliculosus Species 0.000 description 1
- 241000235029 Zygosaccharomyces bailii Species 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000012568 clinical material Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0002—Fungal antigens, e.g. Trichophyton, Aspergillus, Candida
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56961—Plant cells or fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6638972A JPS516729B2 (OSRAM) | 1972-07-04 | 1972-07-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2308037A1 true DE2308037A1 (de) | 1974-01-24 |
Family
ID=13314408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19732308037 Pending DE2308037A1 (de) | 1972-07-04 | 1973-02-19 | Verfahren zur herstellung eines antiserums zur serologischen identifizierung von pathogenen arten von candida |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS516729B2 (OSRAM) |
| CH (1) | CH564352A5 (OSRAM) |
| DE (1) | DE2308037A1 (OSRAM) |
| FR (1) | FR2190424B1 (OSRAM) |
| GB (1) | GB1411661A (OSRAM) |
| NL (1) | NL7302127A (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082890A1 (de) * | 1981-11-03 | 1983-07-06 | Pál Dr. Sutka | Verfahren zur Herstellung von immunbiologischen Präparaten, geeignet für den Nachweis von, die Vorbeugung gegen und/oder die Behandlung von Infektionen durch Candida guilliermondii |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2598513B1 (fr) * | 1986-02-06 | 1991-12-13 | Chemunex | Nouveaux anticorps antilevures capables de reconnaitre plusieurs levures, lignees cellulaires hybrides produisant de tels anticorps, leur preparation et leurs utilisations et applications a la detection et eventuellement a la numeration de levures |
| FR2680519B1 (fr) * | 1991-08-22 | 1993-11-05 | Diagnostica Stago | Procede pour mettre en evidence l'affinite du fibrinogene et de ses derives aux formes filamentaires de levures, utilisation dans le domaine de la determination des levures pathogenes notamment en hemoculture. |
-
1972
- 1972-07-04 JP JP6638972A patent/JPS516729B2/ja not_active Expired
-
1973
- 1973-02-15 NL NL7302127A patent/NL7302127A/xx not_active Application Discontinuation
- 1973-02-16 CH CH226573A patent/CH564352A5/xx not_active IP Right Cessation
- 1973-02-16 FR FR7305603A patent/FR2190424B1/fr not_active Expired
- 1973-02-19 DE DE19732308037 patent/DE2308037A1/de active Pending
- 1973-03-27 GB GB1477873A patent/GB1411661A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082890A1 (de) * | 1981-11-03 | 1983-07-06 | Pál Dr. Sutka | Verfahren zur Herstellung von immunbiologischen Präparaten, geeignet für den Nachweis von, die Vorbeugung gegen und/oder die Behandlung von Infektionen durch Candida guilliermondii |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7302127A (OSRAM) | 1974-01-08 |
| FR2190424A1 (OSRAM) | 1974-02-01 |
| FR2190424B1 (OSRAM) | 1977-12-30 |
| JPS4926418A (OSRAM) | 1974-03-08 |
| GB1411661A (en) | 1975-10-29 |
| JPS516729B2 (OSRAM) | 1976-03-02 |
| CH564352A5 (OSRAM) | 1975-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |