DE2257265C3 - Stabilisierte Lösungen von Benzidin, o-Dianisidin, o-Dianisidin-Hydrochlorid und bzw. oder o-Tolidln - Google Patents
Stabilisierte Lösungen von Benzidin, o-Dianisidin, o-Dianisidin-Hydrochlorid und bzw. oder o-TolidlnInfo
- Publication number
- DE2257265C3 DE2257265C3 DE2257265A DE2257265A DE2257265C3 DE 2257265 C3 DE2257265 C3 DE 2257265C3 DE 2257265 A DE2257265 A DE 2257265A DE 2257265 A DE2257265 A DE 2257265A DE 2257265 C3 DE2257265 C3 DE 2257265C3
- Authority
- DE
- Germany
- Prior art keywords
- dianisidine
- benzidine
- reagents
- hydrochloride
- propanediol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 title claims description 14
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 title claims description 7
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 title claims description 6
- QHRTZMDBPOUHPU-UHFFFAOYSA-N 4-(4-amino-3-methoxyphenyl)-2-methoxyaniline;hydrochloride Chemical compound Cl.C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 QHRTZMDBPOUHPU-UHFFFAOYSA-N 0.000 title description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 10
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 235000013772 propylene glycol Nutrition 0.000 claims description 6
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 3
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 2
- 230000000087 stabilizing effect Effects 0.000 claims 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 238000010998 test method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 239000012086 standard solution Substances 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 3
- 239000004366 Glucose oxidase Substances 0.000 description 3
- 102000003992 Peroxidases Human genes 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- 239000008351 acetate buffer Substances 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010339 medical test Methods 0.000 description 2
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000036515 potency Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
- Y10T436/144444—Glucose
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20084271A | 1971-11-22 | 1971-11-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2257265A1 DE2257265A1 (de) | 1973-05-30 |
| DE2257265B2 DE2257265B2 (enExample) | 1974-11-07 |
| DE2257265C3 true DE2257265C3 (de) | 1975-06-26 |
Family
ID=22743433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2257265A Expired DE2257265C3 (de) | 1971-11-22 | 1972-11-22 | Stabilisierte Lösungen von Benzidin, o-Dianisidin, o-Dianisidin-Hydrochlorid und bzw. oder o-Tolidln |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3753863A (enExample) |
| JP (1) | JPS49133092A (enExample) |
| AU (1) | AU469201B2 (enExample) |
| DE (1) | DE2257265C3 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876375A (en) * | 1971-11-22 | 1975-04-08 | Jonas Maurukas | Biological composition for use as a reference control in diagnostic analysis |
| US3920580A (en) * | 1973-07-12 | 1975-11-18 | Miles Lab | Liquid control solution |
| US4380585A (en) * | 1979-11-13 | 1983-04-19 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4290773A (en) * | 1979-11-13 | 1981-09-22 | Miles Laboratories, Inc. | Stabilization of benzidine-type indicators with various enhancers |
| US4279993A (en) * | 1979-11-13 | 1981-07-21 | Magers Thomas A | Indicator composition and test device containing amine oxide, and method of use |
| JPS59192962A (ja) * | 1983-04-15 | 1984-11-01 | Kyowa Hakko Kogyo Co Ltd | ラテツクス試薬 |
| EP0196743A3 (en) * | 1985-01-31 | 1988-10-19 | Savyon Diagnostics Ltd. | Stable chemical compositions containing chromogenic materials and peroxides, and method for obtaining them |
| US8071384B2 (en) * | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
| US20060117475A1 (en) * | 2004-12-06 | 2006-06-08 | William Hsu | Portable and disposable toilet for temporary use |
| JP4656603B2 (ja) * | 2005-09-29 | 2011-03-23 | 三浦工業株式会社 | 残留塩素濃度測定用組成物 |
-
1971
- 1971-11-22 US US00200842A patent/US3753863A/en not_active Expired - Lifetime
-
1972
- 1972-11-14 AU AU48844/72A patent/AU469201B2/en not_active Expired
- 1972-11-22 DE DE2257265A patent/DE2257265C3/de not_active Expired
- 1972-11-22 JP JP47116723A patent/JPS49133092A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2257265B2 (enExample) | 1974-11-07 |
| DE2257265A1 (de) | 1973-05-30 |
| AU4884472A (en) | 1974-05-16 |
| JPS49133092A (enExample) | 1974-12-20 |
| AU469201B2 (en) | 1976-02-05 |
| US3753863A (en) | 1973-08-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2257265C3 (de) | Stabilisierte Lösungen von Benzidin, o-Dianisidin, o-Dianisidin-Hydrochlorid und bzw. oder o-Tolidln | |
| DE69333605T2 (de) | Stabile injizierbare Paclitaxel Lösung | |
| DE1523133C3 (de) | Vergleichsstandard zur kolorimetrischen Bestimmung des Gesamtcholesterins im menschlichen Blutplasma | |
| DE1189763B (de) | Reagens zur Kontrolle der Gerinnungsfaehigkeit des Blutes waehrend einer Antikoagulantien-Therapie und Verfahren zur Herstellung des Reagens | |
| DE2602997C2 (de) | Lyophilisierte Kollagenzubereitung und Verfahren zu ihrer Herstellung | |
| SCHAUS | The ascorbic acid content of human pituitary, cerebral cortex, heart, and skeletal muscle and its relation to age | |
| DE2928880C2 (de) | Bilirubin-Standard-Zubereitung mit verbesserter Stabilität | |
| DE3107060A1 (de) | Kontroll- oder eichserum und verfahren zu seiner herstellung | |
| EP0141922A1 (de) | Verfahren zur Verringerung einer Trübung in Kontrollseren | |
| DE2256331B2 (de) | Verfahren zur quantitativen kolorimetrischen Harnsäurebestimmung | |
| Dick et al. | Further observations on the determination of molybdenum in plant and animal tissue. | |
| DE2845156A1 (de) | Verfahren zur bestimmung der aktivitaet von alkalischer phosphatase | |
| DE68903670T2 (de) | Physiologisch aktive, fluessige, allergenische zusammensetzungen aus biologischen rohmaterialien. | |
| DE2314263A1 (de) | Synthetischer kontrollstandard zur analyse der cerebrospinalen fluessigkeit und seine herstellung | |
| Briefer | Photometric and electrometric measurements of gelatin behavior | |
| DE1543967C (de) | Reagenz zur Bestimmung der alkalischen Phosphatase | |
| DE2302721B1 (de) | Verfahren zur Bestimmung der Creatinkinase | |
| DE1236239B (de) | Reagens zur Bestimmung gonadotroper Hormone | |
| DE1916132A1 (de) | Papierstreifen zur klinischen Diagnose und Verfahren zu seiner Herstellung | |
| DE2722077C3 (de) | Verfahren sowie wäßrige und lyophilisierte Zusammensetzungen zur Bestimmung des Endotoxingehaltes einer wäßrigen Flüssigkeit | |
| DE1598322C2 (de) | Laboratoriumsreagens zur Bestimmung der Glucose | |
| DE646655C (de) | Verfahren zur Bestimmung des Fettgehaltes, insbesondere von Milch und Milchprodukten | |
| DE1798285C3 (de) | Neues Mittel und Verfahren zur Lipasebesti m mu ng | |
| DE1543967B2 (de) | Reagenz zur Bestimmung der alkalischen Phosphatase | |
| DE2623800A1 (de) | Uebersaettigte waessrige isosorbiddinitratloesung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 |