DE2257132C3 - Verfahren zur Reduktion von 3-Ketosteroiden - Google Patents

Verfahren zur Reduktion von 3-Ketosteroiden

Info

Publication number
DE2257132C3
DE2257132C3 DE2257132A DE2257132A DE2257132C3 DE 2257132 C3 DE2257132 C3 DE 2257132C3 DE 2257132 A DE2257132 A DE 2257132A DE 2257132 A DE2257132 A DE 2257132A DE 2257132 C3 DE2257132 C3 DE 2257132C3
Authority
DE
Germany
Prior art keywords
steroids
hydroxy
yield
pregnan
melting point
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2257132A
Other languages
German (de)
English (en)
Other versions
DE2257132A1 (de
DE2257132B2 (de
Inventor
Ulrich Dr. Kerb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE2257132A priority Critical patent/DE2257132C3/de
Priority to DD174637A priority patent/DD108080A5/xx
Priority to CH1599673A priority patent/CH586237A5/xx
Priority to DK618373A priority patent/DK134782C/da
Priority to CS7848A priority patent/CS166850B2/cs
Priority to US416095A priority patent/US3875195A/en
Priority to FR7340869A priority patent/FR2207129A1/fr
Priority to JP12908973A priority patent/JPS5710879B2/ja
Priority to HUSCHE452*1A priority patent/HU166940B/hu
Priority to NL7315781A priority patent/NL7315781A/xx
Priority to GB5364273A priority patent/GB1455578A/en
Publication of DE2257132A1 publication Critical patent/DE2257132A1/de
Publication of DE2257132B2 publication Critical patent/DE2257132B2/de
Application granted granted Critical
Publication of DE2257132C3 publication Critical patent/DE2257132C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2257132A 1972-11-18 1972-11-18 Verfahren zur Reduktion von 3-Ketosteroiden Expired DE2257132C3 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE2257132A DE2257132C3 (de) 1972-11-18 1972-11-18 Verfahren zur Reduktion von 3-Ketosteroiden
DD174637A DD108080A5 (US07655688-20100202-C00086.png) 1972-11-18 1973-11-14
CH1599673A CH586237A5 (US07655688-20100202-C00086.png) 1972-11-18 1973-11-14
CS7848A CS166850B2 (US07655688-20100202-C00086.png) 1972-11-18 1973-11-15
US416095A US3875195A (en) 1972-11-18 1973-11-15 Reduction of 3-keto-5 beta-H steroids to 3 beta-hydroxy-5beta-H steroids
DK618373A DK134782C (da) 1972-11-18 1973-11-15 Fremgangsmade til fremstilling af 3beta-hydroxy-5beta-h-steroider
FR7340869A FR2207129A1 (US07655688-20100202-C00086.png) 1972-11-18 1973-11-16
JP12908973A JPS5710879B2 (US07655688-20100202-C00086.png) 1972-11-18 1973-11-16
HUSCHE452*1A HU166940B (US07655688-20100202-C00086.png) 1972-11-18 1973-11-16
NL7315781A NL7315781A (US07655688-20100202-C00086.png) 1972-11-18 1973-11-16
GB5364273A GB1455578A (en) 1972-11-18 1973-11-19 Process for the reduction of 3-keto-steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2257132A DE2257132C3 (de) 1972-11-18 1972-11-18 Verfahren zur Reduktion von 3-Ketosteroiden

Publications (3)

Publication Number Publication Date
DE2257132A1 DE2257132A1 (de) 1974-05-30
DE2257132B2 DE2257132B2 (de) 1981-07-23
DE2257132C3 true DE2257132C3 (de) 1982-05-13

Family

ID=5862375

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2257132A Expired DE2257132C3 (de) 1972-11-18 1972-11-18 Verfahren zur Reduktion von 3-Ketosteroiden

Country Status (11)

Country Link
US (1) US3875195A (US07655688-20100202-C00086.png)
JP (1) JPS5710879B2 (US07655688-20100202-C00086.png)
CH (1) CH586237A5 (US07655688-20100202-C00086.png)
CS (1) CS166850B2 (US07655688-20100202-C00086.png)
DD (1) DD108080A5 (US07655688-20100202-C00086.png)
DE (1) DE2257132C3 (US07655688-20100202-C00086.png)
DK (1) DK134782C (US07655688-20100202-C00086.png)
FR (1) FR2207129A1 (US07655688-20100202-C00086.png)
GB (1) GB1455578A (US07655688-20100202-C00086.png)
HU (1) HU166940B (US07655688-20100202-C00086.png)
NL (1) NL7315781A (US07655688-20100202-C00086.png)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4031117A (en) * 1975-09-22 1977-06-21 Becton, Dickinson And Company Testosterone derivatives
JPS60135172U (ja) * 1984-02-20 1985-09-07 株式会社エバニュ− ロ−ラ−スケ−トの車輪
JPS60135171U (ja) * 1984-02-20 1985-09-07 株式会社エバニュ− ロ−ラ−スケ−トの車輪
JP2545522B2 (ja) * 1985-10-23 1996-10-23 アルコン・ラボラトーリーズ，インコーポレイテッド テトラヒドロ脈管形成抑制ステロイド
JPH01130377U (US07655688-20100202-C00086.png) * 1988-02-24 1989-09-05
EP1558627B1 (en) * 2002-10-28 2010-03-03 Phytopharm Plc Stereospecific reduction of sapogen-3-ones

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Org. Chem., Vol. 28, 1963, S. 3386-3391 *
Organic Reactions in Steroid Chemistry, Vol. 1, 1972, S. 134 *

Also Published As

Publication number Publication date
JPS4981360A (US07655688-20100202-C00086.png) 1974-08-06
JPS5710879B2 (US07655688-20100202-C00086.png) 1982-03-01
CH586237A5 (US07655688-20100202-C00086.png) 1977-03-31
DD108080A5 (US07655688-20100202-C00086.png) 1974-09-05
FR2207129A1 (US07655688-20100202-C00086.png) 1974-06-14
US3875195A (en) 1975-04-01
DK134782B (da) 1977-01-17
HU166940B (US07655688-20100202-C00086.png) 1975-06-28
DK134782C (da) 1977-06-06
DE2257132A1 (de) 1974-05-30
NL7315781A (US07655688-20100202-C00086.png) 1974-05-21
DE2257132B2 (de) 1981-07-23
GB1455578A (en) 1976-11-17
CS166850B2 (US07655688-20100202-C00086.png) 1976-03-29

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Legal Events

Date Code Title Description
OD Request for examination
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee