DE2251197C3 - Verfahren zur Herstellung von hxxochdosierten Tabletten von Tetracyclin- Derivaten - Google Patents
Verfahren zur Herstellung von hxxochdosierten Tabletten von Tetracyclin- DerivatenInfo
- Publication number
- DE2251197C3 DE2251197C3 DE2251197A DE2251197A DE2251197C3 DE 2251197 C3 DE2251197 C3 DE 2251197C3 DE 2251197 A DE2251197 A DE 2251197A DE 2251197 A DE2251197 A DE 2251197A DE 2251197 C3 DE2251197 C3 DE 2251197C3
- Authority
- DE
- Germany
- Prior art keywords
- tablets
- production
- tetracycline
- tetracycline derivatives
- dose tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title claims description 13
- 235000019364 tetracycline Nutrition 0.000 title claims description 13
- 150000003522 tetracyclines Chemical class 0.000 title claims description 13
- 229960002180 tetracycline Drugs 0.000 title claims description 12
- 229930101283 tetracycline Natural products 0.000 title claims description 12
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 239000000203 mixture Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 description 2
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 239000004099 Chlortetracycline Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960004475 chlortetracycline Drugs 0.000 description 1
- 235000019365 chlortetracycline Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2251197A DE2251197C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung von hxxochdosierten Tabletten von Tetracyclin- Derivaten |
| NLAANVRAGE7314091,A NL179452C (nl) | 1972-10-19 | 1973-10-12 | Werkwijze voor het vervaardigen van tabletten met een hoge dosis tetracycline-derivaat. |
| CH1464473A CH595102A5 (en) | 1972-10-19 | 1973-10-16 | Prepn of small tablets, contg pyrazolones |
| SE7314145A SE387535B (sv) | 1972-10-19 | 1973-10-17 | Forfarande for framstellning av hogdoserade tabletter av tetracyklinderivat |
| AU61515/73A AU489047B2 (en) | 1972-10-19 | 1973-10-17 | Process forthe manufacture of tablets containing antibiotics |
| FR7337174A FR2247209B1 (Direct) | 1972-10-19 | 1973-10-18 | |
| AT884673A AT343816B (de) | 1972-10-19 | 1973-10-18 | Verfahren zur herstellung hochdosierter tabletten von tetracyclin-derivaten |
| DK566073A DK147695C (da) | 1972-10-19 | 1973-10-18 | Fremgangsmaade til fremstilling af hoejt doserede tabletter af tetracyclin-derivater |
| BE136878A BE806291A (fr) | 1972-10-19 | 1973-10-19 | Procede de preparation de comprimes contenant des antibiotiques |
| GB4883673A GB1440832A (en) | 1972-10-19 | 1973-10-19 | Pharmaceutical preparation comprising antibiotics |
| JP48116999A JPS5218249B2 (Direct) | 1972-10-19 | 1973-10-19 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2251197A DE2251197C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung von hxxochdosierten Tabletten von Tetracyclin- Derivaten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2251197A1 DE2251197A1 (de) | 1974-05-02 |
| DE2251197B2 DE2251197B2 (de) | 1979-08-30 |
| DE2251197C3 true DE2251197C3 (de) | 1980-05-08 |
Family
ID=5859449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2251197A Expired DE2251197C3 (de) | 1972-10-19 | 1972-10-19 | Verfahren zur Herstellung von hxxochdosierten Tabletten von Tetracyclin- Derivaten |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5218249B2 (Direct) |
| AT (1) | AT343816B (Direct) |
| BE (1) | BE806291A (Direct) |
| DE (1) | DE2251197C3 (Direct) |
| DK (1) | DK147695C (Direct) |
| FR (1) | FR2247209B1 (Direct) |
| GB (1) | GB1440832A (Direct) |
| NL (1) | NL179452C (Direct) |
| SE (1) | SE387535B (Direct) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5414470U (Direct) * | 1977-06-30 | 1979-01-30 | ||
| ATE179606T1 (de) * | 1992-02-25 | 1999-05-15 | Spirig Ag | Minocyclin enthaltende pellets |
| SE9704401D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | Matrix pellets for greasy, oily or sticky drug substances |
-
1972
- 1972-10-19 DE DE2251197A patent/DE2251197C3/de not_active Expired
-
1973
- 1973-10-12 NL NLAANVRAGE7314091,A patent/NL179452C/xx not_active IP Right Cessation
- 1973-10-17 SE SE7314145A patent/SE387535B/xx unknown
- 1973-10-18 DK DK566073A patent/DK147695C/da not_active IP Right Cessation
- 1973-10-18 AT AT884673A patent/AT343816B/de not_active IP Right Cessation
- 1973-10-18 FR FR7337174A patent/FR2247209B1/fr not_active Expired
- 1973-10-19 BE BE136878A patent/BE806291A/xx not_active IP Right Cessation
- 1973-10-19 JP JP48116999A patent/JPS5218249B2/ja not_active Expired
- 1973-10-19 GB GB4883673A patent/GB1440832A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2251197B2 (de) | 1979-08-30 |
| DK147695C (da) | 1985-05-20 |
| JPS5218249B2 (Direct) | 1977-05-20 |
| AU6151573A (en) | 1975-04-17 |
| NL179452B (nl) | 1986-04-16 |
| JPS4971130A (Direct) | 1974-07-10 |
| FR2247209B1 (Direct) | 1978-11-03 |
| NL179452C (nl) | 1986-09-16 |
| SE387535B (sv) | 1976-09-13 |
| AT343816B (de) | 1978-06-26 |
| FR2247209A1 (Direct) | 1975-05-09 |
| GB1440832A (en) | 1976-06-30 |
| NL7314091A (Direct) | 1974-04-23 |
| BE806291A (fr) | 1974-04-19 |
| DK147695B (da) | 1984-11-19 |
| DE2251197A1 (de) | 1974-05-02 |
| ATA884673A (de) | 1977-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |