DE2250993C2 - Antibakterielles Mittel - Google Patents
Antibakterielles MittelInfo
- Publication number
- DE2250993C2 DE2250993C2 DE2250993A DE2250993A DE2250993C2 DE 2250993 C2 DE2250993 C2 DE 2250993C2 DE 2250993 A DE2250993 A DE 2250993A DE 2250993 A DE2250993 A DE 2250993A DE 2250993 C2 DE2250993 C2 DE 2250993C2
- Authority
- DE
- Germany
- Prior art keywords
- mcn
- combination
- proteus
- strains
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003242 anti bacterial agent Substances 0.000 title claims description 5
- 150000003839 salts Chemical class 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 125000004185 ester group Chemical group 0.000 claims description 5
- 230000003301 hydrolyzing effect Effects 0.000 claims description 5
- 238000001727 in vivo Methods 0.000 claims description 5
- 239000011885 synergistic combination Substances 0.000 claims description 4
- 241000588769 Proteus <enterobacteria> Species 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- -1 Acetoxymethyl Chemical group 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 238000013207 serial dilution Methods 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- BWWVAEOLVKTZFQ-NTZNESFSSA-N Amdinocillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)=CN1CCCCCC1 BWWVAEOLVKTZFQ-NTZNESFSSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 241000588767 Proteus vulgaris Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical class OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 229940007042 proteus vulgaris Drugs 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108020004256 Beta-lactamase Proteins 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000588770 Proteus mirabilis Species 0.000 description 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007330 chocolate agar Substances 0.000 description 1
- 229940105050 combination of penicillins Drugs 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5067571A GB1405886A (en) | 1971-11-01 | 1971-11-01 | Synergistic compositions comprising penicillin and cephalosporin antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2250993A1 DE2250993A1 (de) | 1973-05-10 |
| DE2250993C2 true DE2250993C2 (de) | 1982-12-30 |
Family
ID=10456894
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2250993A Expired DE2250993C2 (de) | 1971-11-01 | 1972-10-18 | Antibakterielles Mittel |
| DE2265533A Expired DE2265533C2 (de) | 1971-11-01 | 1972-10-18 | Antibakterielles Mittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2265533A Expired DE2265533C2 (de) | 1971-11-01 | 1972-10-18 | Antibakterielles Mittel |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4956179A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS4852917A (cg-RX-API-DMAC7.html) |
| AT (1) | AT324550B (cg-RX-API-DMAC7.html) |
| AU (1) | AU474065B2 (cg-RX-API-DMAC7.html) |
| DE (2) | DE2250993C2 (cg-RX-API-DMAC7.html) |
| FI (1) | FI792124A7 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2158427B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1405886A (cg-RX-API-DMAC7.html) |
| NL (1) | NL176525C (cg-RX-API-DMAC7.html) |
| NO (1) | NO794295L (cg-RX-API-DMAC7.html) |
| SE (1) | SE401087B (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1479838A (en) * | 1974-02-28 | 1977-07-13 | Fujisawa Pharmaceutical Co | Antibacterial composition |
| GB1579931A (en) * | 1976-04-15 | 1980-11-26 | Leo Pharm Prod Ltd | Bis-penicillanoyl-oxy-alkanes |
| US4345071A (en) | 1976-06-29 | 1982-08-17 | Leo Pharmaceutical Products, Ltd. A/S | Derivatives of penicillanic acid |
| LU77362A1 (cg-RX-API-DMAC7.html) * | 1977-05-17 | 1979-01-19 | ||
| JPS542337A (en) * | 1977-06-08 | 1979-01-09 | Toyama Chem Co Ltd | Bactericidal composition for medical use |
| IL54859A (en) * | 1977-06-21 | 1982-01-31 | Rech Applications Therap | Derivatives of amidinopenicillanic acid,their production and pharmaceutical compositions containing them |
| JPS54126735A (en) * | 1978-03-24 | 1979-10-02 | Toyama Chem Co Ltd | Bactericidal composition for medical use |
| NZ194785A (en) * | 1979-09-21 | 1983-05-31 | Leo Pharm Prod Ltd | Double-layer tablet containing penicillanic acid pro-drug in each layer |
| US6638312B2 (en) * | 2000-08-04 | 2003-10-28 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa (SIS) |
| US8366787B2 (en) * | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
| AU2002320517B2 (en) | 2001-07-16 | 2008-03-13 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorable scaffolds |
| AU2002354913B2 (en) | 2001-07-16 | 2008-07-17 | Depuy Products, Inc. | Unitary surgical device and method |
| US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
| US8337537B2 (en) | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
| US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
| AU2002316696B2 (en) * | 2001-07-16 | 2007-08-30 | Depuy Products, Inc. | Cartilage repair and regeneration scaffold and method |
| US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
| US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
| US7569233B2 (en) | 2004-05-04 | 2009-08-04 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
| US7513866B2 (en) | 2004-10-29 | 2009-04-07 | Depuy Products, Inc. | Intestine processing device and associated method |
| US7354627B2 (en) | 2004-12-22 | 2008-04-08 | Depuy Products, Inc. | Method for organizing the assembly of collagen fibers and compositions formed therefrom |
| US7595062B2 (en) | 2005-07-28 | 2009-09-29 | Depuy Products, Inc. | Joint resurfacing orthopaedic implant and associated method |
| US20070112360A1 (en) * | 2005-11-15 | 2007-05-17 | Patrick De Deyne | Bioprosthetic device |
| US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1167424A (fr) * | 1952-10-29 | 1958-11-25 | American Home Prod | Procédé de fabrication de compositions de pénicilline |
| GB1272660A (en) * | 1969-12-24 | 1972-05-03 | Beecham Group Ltd | Therapeutic compositions |
| US4221781A (en) * | 1971-11-01 | 1980-09-09 | Astra Lakemedel Aktiebolag | Synergistic penicillin-cephalosporin compositions and methods |
-
1971
- 1971-11-01 GB GB5067571A patent/GB1405886A/en not_active Expired
-
1972
- 1972-10-18 DE DE2250993A patent/DE2250993C2/de not_active Expired
- 1972-10-18 DE DE2265533A patent/DE2265533C2/de not_active Expired
- 1972-10-25 AT AT910172A patent/AT324550B/de not_active IP Right Cessation
- 1972-10-25 AU AU48126/72A patent/AU474065B2/en not_active Expired
- 1972-10-26 NL NLAANVRAGE7214478,A patent/NL176525C/xx not_active IP Right Cessation
- 1972-10-31 SE SE7214083A patent/SE401087B/xx unknown
- 1972-10-31 FR FR7238691A patent/FR2158427B1/fr not_active Expired
- 1972-11-01 JP JP47108956A patent/JPS4852917A/ja active Pending
-
1979
- 1979-07-05 FI FI792124A patent/FI792124A7/fi not_active Application Discontinuation
- 1979-12-27 NO NO794295A patent/NO794295L/no unknown
-
1987
- 1987-07-02 US US07/069,787 patent/US4956179A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2158427A1 (cg-RX-API-DMAC7.html) | 1973-06-15 |
| SE401087B (sv) | 1978-04-24 |
| DE2250993A1 (de) | 1973-05-10 |
| AU4812672A (en) | 1974-04-26 |
| FR2158427B1 (cg-RX-API-DMAC7.html) | 1976-07-02 |
| AU474065B2 (en) | 1976-07-15 |
| FI792124A7 (fi) | 1981-01-01 |
| NL176525C (nl) | 1985-05-01 |
| JPS4852917A (cg-RX-API-DMAC7.html) | 1973-07-25 |
| NL7214478A (cg-RX-API-DMAC7.html) | 1973-05-03 |
| DE2265533C2 (de) | 1983-12-29 |
| NO794295L (no) | 1973-05-03 |
| US4956179A (en) | 1990-09-11 |
| NL176525B (nl) | 1984-12-03 |
| AT324550B (de) | 1975-09-10 |
| GB1405886A (en) | 1975-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2250993C2 (de) | Antibakterielles Mittel | |
| DE3686956T2 (de) | Nichtantibakterielle tetracyclinzusammensetzungen mit anticollagenolytischen eigenschaften. | |
| DE69323568T2 (de) | Antimikrobielle Zusammensetzungen und pharmazeutische Präparate hiervon | |
| DE3205018C2 (de) | Verwendung von Cyclodextrin als Bifidobakterien vermehrendes Mittel | |
| EP0655249B1 (de) | Moenomycin als Arzneimittel zur Behandlung von Magengeschwüren | |
| DE2942107A1 (de) | Pharmazeutische zubereitung mit einer antibakteriellen wirkung und ihre verwendung zur behandlung von durch grampositive und gram-negative krankheitserregende keime hervorgerufene infektionen | |
| DE69028520T2 (de) | Arzneimittelzubereitung bei der behandlung von tonsillitis | |
| DE2824610C2 (de) | Arzneimittelgemisch aus einer Penicillansäure und aus einem Penicillin oder Cephalosporin | |
| EP0248361B1 (de) | Pharmazeutische Zubereitung zur Behandlung bakterieller Infektionen | |
| DE2521922A1 (de) | Pharmazeutisches mittel | |
| DE1792223C3 (de) | Arzneipräparate, geeignet zur Behandlung von durch gramnegative Bakterien hervorgerufenen Infektionen | |
| DE2448564C3 (de) | Verwendung von heterocyclischen Carbonsäuren | |
| DE2522081C2 (cg-RX-API-DMAC7.html) | ||
| DE2106154A1 (en) | Antibiotic - resistans streptococcus faecalis - for treatment and prophylaxis of digestive disturbances | |
| DE2027528A1 (de) | Antibakterielles Präparat | |
| EP0000891B1 (de) | Synergistische Kombinationen von Penicillinen und sie enthaltende antibiotische Mittel | |
| DE2508443C2 (de) | Pharmazeutisches Mischpräparat mit antibiotischer Wirkung | |
| DE2650608A1 (de) | Arzneipraeparat zur behandlung von mastitis bei milchvieh | |
| DE3934855A1 (de) | Antibakterielles synergistisches praeparat | |
| AT392903B (de) | Pharmazeutische zubereitung enthaltend ein cephalosporin und ein penemantibiotikum | |
| DE3111035A1 (de) | Aminopenicillin derivat, verfahren zu seiner herstellung und dieses als aktiven wirkstoff enthaltende therapeutische verbindungen | |
| DE2262787A1 (de) | Antibakterielle zusammensetzung | |
| DE1692038A1 (de) | Arzneimittel | |
| DE2259624A1 (de) | Antibakterielles mittel | |
| DE2745946A1 (de) | Antibioticumpraeparat auf erythromycinbasis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OI | Miscellaneous see part 1 | ||
| OI | Miscellaneous see part 1 | ||
| D2 | Grant after examination | ||
| AH | Division in |
Ref country code: DE Ref document number: 2265533 Format of ref document f/p: P |