DE2244328A1 - Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben - Google Patents

Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben

Info

Publication number
DE2244328A1
DE2244328A1 DE2244328A DE2244328A DE2244328A1 DE 2244328 A1 DE2244328 A1 DE 2244328A1 DE 2244328 A DE2244328 A DE 2244328A DE 2244328 A DE2244328 A DE 2244328A DE 2244328 A1 DE2244328 A1 DE 2244328A1
Authority
DE
Germany
Prior art keywords
general formula
adenosine
adenosine derivatives
lower alkyl
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2244328A
Other languages
German (de)
English (en)
Inventor
Erich Dr Techn Fauland
Wolfgang Dr Rer Nat Kampe
Helmut Dr Rer Nat Schmidt
Kurt Dr Ing Stach
Harald Dr Med Stork
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2244328A priority Critical patent/DE2244328A1/de
Priority to AR249872A priority patent/AR196450A1/es
Priority to GB4131873A priority patent/GB1385830A/en
Priority to DK485973AA priority patent/DK130833B/da
Priority to ZA736044A priority patent/ZA736044B/xx
Priority to US393859A priority patent/US3880829A/en
Priority to CH735376A priority patent/CH579588A5/xx
Priority to DD173293A priority patent/DD108086A5/xx
Priority to CH1276773A priority patent/CH579586A5/xx
Priority to NL7312260A priority patent/NL7312260A/xx
Priority to CS7600006758A priority patent/CS181750B2/cs
Priority to CS7300006219A priority patent/CS181727B2/cs
Priority to HUBO1461A priority patent/HU168734B/hu
Priority to SU1962240A priority patent/SU515459A3/ru
Priority to ES418572A priority patent/ES418572A1/es
Priority to AT778473A priority patent/AT329192B/de
Priority to CA180,715A priority patent/CA1000273A/en
Priority to FR7332281A priority patent/FR2198749B1/fr
Priority to AU60132/73A priority patent/AU447933B2/en
Priority to SE7312206A priority patent/SE400770B/xx
Priority to ZA737172*A priority patent/ZA737172B/xx
Priority to JP48102014A priority patent/JPS5229755B2/ja
Priority to AR251431A priority patent/AR199237A1/es
Publication of DE2244328A1 publication Critical patent/DE2244328A1/de
Priority to AT845174A priority patent/AT330370B/de
Priority to US05/525,795 priority patent/US3966916A/en
Priority to SU2099424A priority patent/SU533338A3/ru
Priority to NL7512407A priority patent/NL7512407A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2244328A 1972-09-09 1972-09-09 Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben Pending DE2244328A1 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
DE2244328A DE2244328A1 (de) 1972-09-09 1972-09-09 Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben
AR249872A AR196450A1 (es) 1972-09-09 1973-09-03 Procedimiento para la preparacion de derivados n(6)-disustituidos de adenosina
GB4131873A GB1385830A (en) 1972-09-09 1973-09-03 N6-disubstituted adenosine derivatives methods for their preparation and compositions containing them
DK485973AA DK130833B (da) 1972-09-09 1973-09-04 Analogifremgangsmåde til fremstilling af N(6)-disubstituerede adenosinderivater.
ZA736044A ZA736044B (en) 1972-09-09 1973-09-04 New n(6)-disubstituted adenosine derivatives
US393859A US3880829A (en) 1972-09-09 1973-09-04 N(6)-disubstituted adenosine compounds
CH735376A CH579588A5 (https=) 1972-09-09 1973-09-05
DD173293A DD108086A5 (https=) 1972-09-09 1973-09-05
CH1276773A CH579586A5 (https=) 1972-09-09 1973-09-05
NL7312260A NL7312260A (https=) 1972-09-09 1973-09-06
CS7600006758A CS181750B2 (en) 1972-09-09 1973-09-06 Method of producing n/6/-disubstituted derivatives of adenosine
CS7300006219A CS181727B2 (en) 1972-09-09 1973-09-06 Process for preparing n/6/-disubstituted derivatives of adenosine
SU1962240A SU515459A3 (ru) 1972-09-09 1973-09-07 Способ получени /6//-дизамещенных производных аденозина"
HUBO1461A HU168734B (https=) 1972-09-09 1973-09-07
ES418572A ES418572A1 (es) 1972-09-09 1973-09-07 Procedimiento para la preparacion de derivados de adenosinadisustituidos en n (6).
AT778473A AT329192B (de) 1972-09-09 1973-09-07 Verfahren zur herstellung neuer n(6)-disubstituierter adenosin-derivate
CA180,715A CA1000273A (en) 1972-09-09 1973-09-07 N(6)-disubstituted adenosine derivatives
FR7332281A FR2198749B1 (https=) 1972-09-09 1973-09-07
AU60132/73A AU447933B2 (en) 1972-12-09 1973-09-07 New n(6)-disubstituted adenosine derivatives
SE7312206A SE400770B (sv) 1972-09-09 1973-09-07 Forfarande for framstellning av n(6)-disubstituerade adenosinderivat
ZA737172*A ZA737172B (en) 1972-09-09 1973-09-07 Process for separating cobalt and nickel
JP48102014A JPS5229755B2 (https=) 1972-09-09 1973-09-10
AR251431A AR199237A1 (es) 1972-09-09 1973-12-10 Un procedimiento para la preparacion de derivados n(6)-disubstituidos de adenosina
AT845174A AT330370B (de) 1972-09-09 1974-10-21 Verfahren zur herstellung neuer n(6)-disubstituierter adenosin-derivate
US05/525,795 US3966916A (en) 1972-09-09 1974-11-21 N(6)-disubstituted adenoisine compounds and therapeutic compositions
SU2099424A SU533338A3 (ru) 1972-09-09 1975-01-20 Способ получени /6/-дизамещенных производных аденозина или их солей
NL7512407A NL7512407A (nl) 1972-09-09 1975-10-23 Werkwijze voor het bereiden van een n(6)-digesub- stitueerd adenosinederivaat met farmacologische werking.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2244328A DE2244328A1 (de) 1972-09-09 1972-09-09 Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben

Publications (1)

Publication Number Publication Date
DE2244328A1 true DE2244328A1 (de) 1974-03-21

Family

ID=5855897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2244328A Pending DE2244328A1 (de) 1972-09-09 1972-09-09 Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben

Country Status (18)

Country Link
US (1) US3880829A (https=)
JP (1) JPS5229755B2 (https=)
AR (2) AR196450A1 (https=)
AT (1) AT329192B (https=)
CA (1) CA1000273A (https=)
CH (2) CH579588A5 (https=)
CS (2) CS181750B2 (https=)
DD (1) DD108086A5 (https=)
DE (1) DE2244328A1 (https=)
DK (1) DK130833B (https=)
ES (1) ES418572A1 (https=)
FR (1) FR2198749B1 (https=)
GB (1) GB1385830A (https=)
HU (1) HU168734B (https=)
NL (2) NL7312260A (https=)
SE (1) SE400770B (https=)
SU (2) SU515459A3 (https=)
ZA (2) ZA736044B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432166A (en) * 1991-05-30 1995-07-11 Burroughs Wellcome Co. Use of 1-(β-D-arabinofuranosyl) -5-propynyluracil for lowering serum cholesterol

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds
US9102698B2 (en) 2007-03-14 2015-08-11 Can-Fite Biopharma Ltd. Process for the synthesis of IB-MECA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128629C (https=) * 1966-05-07
DE1670077C3 (de) * 1966-05-07 1975-04-24 Boehringer Mannheim Gmbh, 6800 Mannheim Adenosin-Derivate und Verfahren zu ihrer Herstellung
US3506643A (en) * 1966-12-09 1970-04-14 Max Thiel N**6-aralkyl-adenosine derivatives
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432166A (en) * 1991-05-30 1995-07-11 Burroughs Wellcome Co. Use of 1-(β-D-arabinofuranosyl) -5-propynyluracil for lowering serum cholesterol

Also Published As

Publication number Publication date
DK130833B (da) 1975-04-21
SE400770B (sv) 1978-04-10
CS181727B2 (en) 1978-03-31
ES418572A1 (es) 1976-04-16
AR196450A1 (es) 1973-12-27
CH579586A5 (https=) 1976-09-15
SU515459A3 (ru) 1976-05-25
AT329192B (de) 1976-04-26
NL7512407A (nl) 1976-02-27
FR2198749A1 (https=) 1974-04-05
GB1385830A (en) 1975-03-05
JPS4966695A (https=) 1974-06-27
JPS5229755B2 (https=) 1977-08-03
ZA737172B (en) 1974-08-28
ZA736044B (en) 1974-09-25
CH579588A5 (https=) 1976-09-15
AU6013273A (en) 1974-05-02
AR199237A1 (es) 1974-08-14
DD108086A5 (https=) 1974-09-05
DK130833C (https=) 1975-09-22
ATA778473A (de) 1975-07-15
SU533338A3 (ru) 1976-10-25
CS181750B2 (en) 1978-03-31
US3880829A (en) 1975-04-29
HU168734B (https=) 1976-07-28
CA1000273A (en) 1976-11-23
FR2198749B1 (https=) 1977-01-28
NL7312260A (https=) 1974-03-12

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