DE2234709C2 - Prostanoesäurederivate und Verfahren zu deren Herstellung - Google Patents

Prostanoesäurederivate und Verfahren zu deren Herstellung

Info

Publication number
DE2234709C2
DE2234709C2 DE2234709A DE2234709A DE2234709C2 DE 2234709 C2 DE2234709 C2 DE 2234709C2 DE 2234709 A DE2234709 A DE 2234709A DE 2234709 A DE2234709 A DE 2234709A DE 2234709 C2 DE2234709 C2 DE 2234709C2
Authority
DE
Germany
Prior art keywords
solution
mixture
compounds
formula
prostanoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2234709A
Other languages
German (de)
English (en)
Other versions
DE2234709A1 (de
Inventor
Keith Blakeney Macclesfield Cheshire Mallion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE2234709A1 publication Critical patent/DE2234709A1/de
Application granted granted Critical
Publication of DE2234709C2 publication Critical patent/DE2234709C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
DE2234709A 1971-07-14 1972-07-14 Prostanoesäurederivate und Verfahren zu deren Herstellung Expired DE2234709C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3304971 1971-07-14
GB3304971A GB1372541A (en) 1971-07-14 1971-12-16 Cyclopentane derivatives

Publications (2)

Publication Number Publication Date
DE2234709A1 DE2234709A1 (de) 1973-02-01
DE2234709C2 true DE2234709C2 (de) 1982-06-03

Family

ID=26261688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2234709A Expired DE2234709C2 (de) 1971-07-14 1972-07-14 Prostanoesäurederivate und Verfahren zu deren Herstellung

Country Status (12)

Country Link
JP (1) JPS5629665B1 (enExample)
BE (1) BE786251A (enExample)
CA (1) CA986926A (enExample)
CH (1) CH575902A5 (enExample)
DD (1) DD102141A5 (enExample)
DE (1) DE2234709C2 (enExample)
FR (1) FR2145697B1 (enExample)
GB (1) GB1372541A (enExample)
HU (1) HU166719B (enExample)
IE (1) IE36914B1 (enExample)
NL (1) NL7209817A (enExample)
SE (2) SE399706B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361410A1 (fr) * 1972-07-13 1978-03-10 Pfizer Alkylphosphonates de dialkyle, utiles comme intermediaires de synthese de prostaglandines
US4113723A (en) 1972-07-13 1978-09-12 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
GB1431561A (en) * 1973-01-31 1976-04-07 Ici Ltd Cyclopentane derivatives
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
ATE420857T1 (de) 1988-09-06 2009-01-15 Pfizer Health Ab Prostaglandin-derivate zur behandlung von glaukom und ocularer hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5741810A (en) 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
WO2004026245A2 (en) * 2002-09-19 2004-04-01 Ilex Oncology Research, Sarl Substituted phosphonate compounds having bone anabolic activity
US7642370B2 (en) 2006-08-07 2010-01-05 Daiichi Fine Chemical Co., Ltd. Method for preparing prostaglandin derivative

Also Published As

Publication number Publication date
DD102141A5 (enExample) 1973-12-05
SE7504707L (enExample) 1975-04-23
IE36914B1 (en) 1977-03-30
BE786251A (fr) 1973-01-15
AU4394072A (en) 1974-01-03
FR2145697B1 (enExample) 1976-04-16
CA986926A (en) 1976-04-06
FR2145697A1 (enExample) 1973-02-23
GB1372541A (en) 1974-10-30
CH575902A5 (enExample) 1976-05-31
NL7209817A (enExample) 1973-01-16
DE2234709A1 (de) 1973-02-01
IE36914L (en) 1973-01-14
JPS5629665B1 (enExample) 1981-07-09
HU166719B (enExample) 1975-05-28
SE399706B (sv) 1978-02-27

Similar Documents

Publication Publication Date Title
DE2223365C3 (de) Prostansäurederivate, Verfahren zu ihrer Herstellung, solche Derivate enthaltende pharmazeutische und veterinäre Zusammensetzungen sowie Zwischenprodukte zur Herstellung dieser Derivate
DE2154309C3 (de) 17-Phenyl-18,19,20-trinor-PGE↓2↓ und - PGF↓2↓ α und dieselben enthaltende Arzneimittel
DE2437388A1 (de) Prostansaeurederivate
DE2242239C2 (de) 2-Descarboxy-2- (tetrazol-5-yl) prostaglandine der A-, E- oder F-Reihe
DE2313868A1 (de) 11-deoxyprostaglandinderivate und deren herstellungsverfahren
DE2234709C2 (de) Prostanoesäurederivate und Verfahren zu deren Herstellung
DE3306123A1 (de) Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CH618968A5 (enExample)
DE2322142C2 (de) Prostansäurederivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische oder veterinäre Zuammensetzungen
DE2150361A1 (de) Prostanoesaeurederivate
DE2360893A1 (de) Cyclopentanderivate
DE2337581A1 (de) Derivate von 9-hydroxy-13-trans-prostensaeure
CH623570A5 (enExample)
DE2739277A1 (de) 11-deoxy-11-oxaprostaglandinverbindungen
DE2555210A1 (de) Neue analoga natuerlich vorkommender prostaglandine
DE2355042A1 (de) Neue prostaglandinanaloge und verfahren zu deren herstellung
DE2234708A1 (de) Prostanoesaeurederivate
DE2716075A1 (de) Neue zwischenprodukte und verfahren zur herstellung von thromboxan-analoga
DE2637384A1 (de) Prostanderivate
DE2917456A1 (de) Imidazolderivate und ihre ungiftigen salze, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzung
DD207901A5 (de) Verfahren zur herstellung von carbacyclinderivaten
DE2404654A1 (de) Cyclopentanderivate
DE3006708A1 (de) Thromboxananaloge und thromboxanzwischenprodukte
DE2626287A1 (de) Prostanderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittelzusammensetzung
DE2344838C3 (de) 18-Oxa- und 19-Oxa-prostaglandinverbindungen sowie 20-Oxa- und 19-Oxa-omega-homo-prostaglandinverbindungen und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8339 Ceased/non-payment of the annual fee