DE2232827A1 - Neue steroide und verfahren zu ihrer herstellung - Google Patents

Neue steroide und verfahren zu ihrer herstellung

Info

Publication number
DE2232827A1
DE2232827A1 DE2232827A DE2232827A DE2232827A1 DE 2232827 A1 DE2232827 A1 DE 2232827A1 DE 2232827 A DE2232827 A DE 2232827A DE 2232827 A DE2232827 A DE 2232827A DE 2232827 A1 DE2232827 A1 DE 2232827A1
Authority
DE
Germany
Prior art keywords
adamantane
compound
salt
carboxylic acid
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE2232827A
Other languages
German (de)
English (en)
Inventor
Alan Frederick English
Gordon Hanley Phillipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of DE2232827A1 publication Critical patent/DE2232827A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2232827A 1971-07-05 1972-07-04 Neue steroide und verfahren zu ihrer herstellung Ceased DE2232827A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3134971A GB1391443A (en) 1971-07-05 1971-07-05 Ester of betamethasone and its 9alpha-chloro analogue

Publications (1)

Publication Number Publication Date
DE2232827A1 true DE2232827A1 (de) 1973-01-18

Family

ID=10321802

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2232827A Ceased DE2232827A1 (de) 1971-07-05 1972-07-04 Neue steroide und verfahren zu ihrer herstellung

Country Status (17)

Country Link
JP (1) JPS5644079B1 (enrdf_load_stackoverflow)
AR (2) AR194120A1 (enrdf_load_stackoverflow)
AU (1) AU464251B2 (enrdf_load_stackoverflow)
BE (1) BE785812A (enrdf_load_stackoverflow)
CA (1) CA983919A (enrdf_load_stackoverflow)
CH (1) CH609065A5 (enrdf_load_stackoverflow)
DE (1) DE2232827A1 (enrdf_load_stackoverflow)
DK (1) DK131474B (enrdf_load_stackoverflow)
FR (1) FR2144761B1 (enrdf_load_stackoverflow)
GB (1) GB1391443A (enrdf_load_stackoverflow)
IE (1) IE36529B1 (enrdf_load_stackoverflow)
IL (1) IL39821A (enrdf_load_stackoverflow)
NL (1) NL169882C (enrdf_load_stackoverflow)
NO (1) NO137754C (enrdf_load_stackoverflow)
PH (1) PH13195A (enrdf_load_stackoverflow)
SE (1) SE385904B (enrdf_load_stackoverflow)
ZA (1) ZA724598B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2512915A1 (de) * 1974-03-27 1975-10-09 Plurichemie Anstalt 16-methyl-9 alpha-halogen-steroide ester, aether und verfahren zu ihrer herstellung

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5024427A (enrdf_load_stackoverflow) * 1973-01-03 1975-03-15
JPS6163976U (enrdf_load_stackoverflow) * 1984-10-01 1986-05-01
JP5780521B2 (ja) 2008-05-28 2015-09-16 リベラジェン・バイオファーマ・インコーポレイテッドＲｅｖｅｒａＧｅｎ ＢｉｏＰｈａｒｍａ，Ｉｎｃ． 疾患を治療するための、ＮＦ−κＢの非ホルモン性ステロイド調節因子
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2512915A1 (de) * 1974-03-27 1975-10-09 Plurichemie Anstalt 16-methyl-9 alpha-halogen-steroide ester, aether und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NL169882C (nl) 1982-09-01
GB1391443A (en) 1975-04-23
IL39821A0 (en) 1972-09-28
JPS5644079B1 (enrdf_load_stackoverflow) 1981-10-16
IL39821A (en) 1976-02-29
CH609065A5 (en) 1979-02-15
AR194553A1 (es) 1973-07-23
IE36529B1 (en) 1976-11-24
AU4420572A (en) 1974-01-10
BE785812A (fr) 1973-01-04
NO137754B (no) 1978-01-09
ZA724598B (en) 1973-03-28
IE36529L (en) 1973-01-05
CA983919A (en) 1976-02-17
FR2144761B1 (enrdf_load_stackoverflow) 1976-03-05
PH13195A (en) 1980-01-18
AR194120A1 (es) 1973-06-22
SE385904B (sv) 1976-07-26
DK131474B (da) 1975-07-21
NO137754C (no) 1978-04-19
DK131474C (enrdf_load_stackoverflow) 1975-12-08
NL169882B (nl) 1982-04-01
NL7209345A (enrdf_load_stackoverflow) 1973-01-09
AU464251B2 (en) 1975-08-21
FR2144761A1 (enrdf_load_stackoverflow) 1973-02-16

Similar Documents

Publication Publication Date Title
DE69720996T2 (de) Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer
DE2222491C3 (de) Steroid-21-salpetersäureester der Pregnanreihe, solche enthaltende Arzneimittel und Verfahren zur Herstellung derselben
DE68910211T2 (de) Estramustin-ester.
DE2232827A1 (de) Neue steroide und verfahren zu ihrer herstellung
DE1951790C3 (de) In 17-StelIung veresterte Steroid-21-phosphate der Pregnanreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Zubereitungen
DE69306303T2 (de) Monoquaternäre 2,16-Bispiperidinglandrostanderivate
DE2323744C3 (de) 4,4'-Bismethylen-(3-methoxy-2-naphthoesäure-triamcinolon-acetonidester) und Verfahren zu dessen Herstellung
EP0100516A2 (de) 3-Beta-(3'-(Carboxypropionyloxy))-ursa-9(11),12-dien-28-carbonsäure sowie ihre Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1643033B2 (de) 9 alpha, 11 beta-dichlor-16 alpha- methyl-1,4-pregnadien-17 alpha, 21-diol- 3,20-dion-17-ester verfahren zu ihrer herstellung und sie enthaltende therapeutische zubereitungen
DE69518258T2 (de) Kortikoidderivate und pharmazeutische und kosmetische Zusammensetzungen
DE1934392C3 (de) Neue 2-Pyridylthioamide und Verfahren zu ihrer Herstellung
DE2337882C3 (de) Bis-Piperazino-Androstan-Derivate und Verfahren zu ihrer Herstellung
DE2162592A1 (de) Steroide der 5 alpha-Pregnan-Reihen
EP0313935A2 (de) Enolether von 6-Chlor-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno(2,3-e)-1,2-thiazin-3-carbonsäureamid-1,1-dioxid, ein Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE3116891A1 (de) Steroid-oxazole
DE2300166A1 (de) Neue steroidverbindungen und verfahren zu ihrer herstellung
CH597256A5 (en) Dexamethasone 21-adamantoate
CH526526A (de) Verfahren zur Herstellung eines neuen 6a-Methyl-19-nor-progesterons
DE2031205C3 (de) Verfahren zur Herstellung von 17-Monoestern von 17 alpha, 21-Dihydroxy-20-ketosteroiden und Prednisolon-17benzoat
DE1922126C3 (de) 6,17-Dichlor-A4'6 -pregnadiene, Verfahren zu deren Herstellung, diese enthaltende Arzneimittel sowie
DE1468681C3 (de) 17beta-Tetrahydropyranyloxy verbindungen der Androstanreihe sowie Verfahren zu ihrer Herstellung und Heilmittel
AT361644B (de) Verfahren zur herstellung von neuen d-homosteroiden
DE2152001C3 (de) 3-Piperidino- und 3-Morpholinopropylbenzoate und deren Salze, Verfahren zur Herstellung derselben sowie solche Verbindungen enthaltende Arzneimittel
DE1418320C (de) Verfahren zur Herstellung von 16 alpha-Methyl- 1,4-pregnadien-17 alpha, 21-diol-3,11,20-trion und von entsprechenden 21niedermolekularen Alkansäureestern desselben
DE1493313C (de) 16b, 17 Cycloenolather des 17alpha Hydroxy öalpha methyl 3,20 dioxo 4 pregnen 16alpha acetaldehyds und des 1 lbeta, 17alpha Dihydroxy 9alpha fluor 6alpha methyl 3,20 dioxo 1,4 pregnadien 16alpha acetaldehyds und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
OD Request for examination
8131 Rejection