DE2203653C3 - 3-Carbamoyloxymethyl-7-(2-thienylacetamido)-3-cephem-4-carbonsäure und deren Salze, Verfahren zur Herstellung dieser Verbindungen und solche Verbindungen enthaltende Arzneimittel - Google Patents

3-Carbamoyloxymethyl-7-(2-thienylacetamido)-3-cephem-4-carbonsäure und deren Salze, Verfahren zur Herstellung dieser Verbindungen und solche Verbindungen enthaltende Arzneimittel

Info

Publication number
DE2203653C3
DE2203653C3 DE19722203653 DE2203653A DE2203653C3 DE 2203653 C3 DE2203653 C3 DE 2203653C3 DE 19722203653 DE19722203653 DE 19722203653 DE 2203653 A DE2203653 A DE 2203653A DE 2203653 C3 DE2203653 C3 DE 2203653C3
Authority
DE
Germany
Prior art keywords
compounds
cephem
carboxylic acid
carbamoyloxymethyl
thienylacetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19722203653
Other languages
German (de)
English (en)
Other versions
DE2203653A1 (de
DE2203653B2 (de
Inventor
Lovji Dadi Edison Cama
Burton Grant Scotch Plains Christensen
Jo Ann Woodbridge Kern
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2203653A1 publication Critical patent/DE2203653A1/de
Publication of DE2203653B2 publication Critical patent/DE2203653B2/de
Application granted granted Critical
Publication of DE2203653C3 publication Critical patent/DE2203653C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19722203653 1971-01-27 1972-01-26 3-Carbamoyloxymethyl-7-(2-thienylacetamido)-3-cephem-4-carbonsäure und deren Salze, Verfahren zur Herstellung dieser Verbindungen und solche Verbindungen enthaltende Arzneimittel Expired DE2203653C3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB329571A GB1350772A (en) 1971-01-27 1971-01-27 Antibiotics and processes for their production
GB2852271 1971-06-17
GB3965471 1971-08-24
GB182972 1972-01-14

Publications (3)

Publication Number Publication Date
DE2203653A1 DE2203653A1 (de) 1972-08-10
DE2203653B2 DE2203653B2 (de) 1974-12-19
DE2203653C3 true DE2203653C3 (de) 1975-07-31

Family

ID=27447180

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19722203653 Expired DE2203653C3 (de) 1971-01-27 1972-01-26 3-Carbamoyloxymethyl-7-(2-thienylacetamido)-3-cephem-4-carbonsäure und deren Salze, Verfahren zur Herstellung dieser Verbindungen und solche Verbindungen enthaltende Arzneimittel

Country Status (10)

Country Link
JP (1) JPS5418274B1 (enExample)
AR (1) AR204899A1 (enExample)
AU (1) AU468248B2 (enExample)
BE (1) BE778508A (enExample)
CA (1) CA1003404A (enExample)
CH (1) CH569021A5 (enExample)
DE (1) DE2203653C3 (enExample)
FR (1) FR2161866B1 (enExample)
GB (1) GB1350772A (enExample)
IE (1) IE36192B1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905963A (en) * 1972-01-25 1975-09-16 Lilly Co Eli Process for preparing primary 3-carbamoyloxymethyl cephalosporins
US3994875A (en) * 1974-06-24 1976-11-30 Yeda Research & Development Co. Ltd. Antibiotics
CA1128930A (en) 1978-04-07 1982-08-03 Stuart B. Laing Cephalosporin compounds
CA2109084C (en) * 1991-05-03 2004-02-24 John William Fisher Costerton Biofilm reduction method
WO2004083217A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefoxitin
CN101830913B (zh) * 2010-04-09 2012-10-31 烟台宝华生物技术有限公司 头孢母核衍生化合物、由其制备的头孢烯类鎓盐化合物及采用其制备硫酸头孢吡唑的方法
CN103848851B (zh) * 2012-11-29 2016-03-02 上海交通大学 一种盐酸头孢卡品酯的合成方法
BR112021013710A2 (pt) 2019-01-29 2021-09-21 Nipro Corporation Dispositivo de pulmão artificial

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445633A1 (de) 1963-10-07 1968-12-05 Ciba Geigy Verfahren zur Herstellung neuer Amide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH480365A (de) * 1965-01-18 1969-10-31 Ciba Geigy Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1445633A1 (de) 1963-10-07 1968-12-05 Ciba Geigy Verfahren zur Herstellung neuer Amide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ber. 96, 1963, 56-67

Also Published As

Publication number Publication date
AU468248B2 (en) 1976-01-08
DE2203653A1 (de) 1972-08-10
AU3835672A (en) 1973-08-02
IE36192L (en) 1972-07-27
CA1003404A (en) 1977-01-11
GB1350772A (en) 1974-04-24
FR2161866B1 (enExample) 1975-08-01
AR204899A1 (es) 1976-03-19
BE778508A (fr) 1972-07-26
JPS5418274B1 (enExample) 1979-07-06
CH569021A5 (enExample) 1975-11-14
DE2203653B2 (de) 1974-12-19
IE36192B1 (en) 1976-09-15
FR2161866A1 (enExample) 1973-07-13

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Date Code Title Description
C3 Grant after two publication steps (3rd publication)
E77 Valid patent as to the heymanns-index 1977
AH Division in

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