DE2115281A1 - 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung - Google Patents

4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung

Info

Publication number
DE2115281A1
DE2115281A1 DE19712115281 DE2115281A DE2115281A1 DE 2115281 A1 DE2115281 A1 DE 2115281A1 DE 19712115281 DE19712115281 DE 19712115281 DE 2115281 A DE2115281 A DE 2115281A DE 2115281 A1 DE2115281 A1 DE 2115281A1
Authority
DE
Germany
Prior art keywords
hydroxy
pyrrolidino
phenyl
pentane
diastereomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712115281
Other languages
German (de)
English (en)
Inventor
Ernst Dipl.-Chem. Dr.; Kähling Joachim Dr.; Engel Wolfhard Dipl.-Chem. Dr.; 7950 Biberach Seeger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19712115281 priority Critical patent/DE2115281A1/de
Priority to US00238660A priority patent/US3801592A/en
Priority to ES401273A priority patent/ES401273A1/es
Priority to IL39100A priority patent/IL39100A/xx
Priority to CA138,421A priority patent/CA967968A/en
Priority to GB1488872A priority patent/GB1379959A/en
Priority to ZA722161A priority patent/ZA722161B/xx
Priority to BE781423A priority patent/BE781423A/xx
Priority to AT273972A priority patent/AT310730B/de
Priority to NL7204230A priority patent/NL7204230A/xx
Priority to FR7211260A priority patent/FR2132244B1/fr
Publication of DE2115281A1 publication Critical patent/DE2115281A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19712115281 1971-03-30 1971-03-30 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung Pending DE2115281A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19712115281 DE2115281A1 (de) 1971-03-30 1971-03-30 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung
US00238660A US3801592A (en) 1971-03-30 1972-03-27 4-hydroxy-1-phenyl-2-pyrrolidinopentane and salts thereof
ES401273A ES401273A1 (es) 1971-03-30 1972-03-28 Procedimiento para la preparacion de 4 - hidroxi - 1 - fe- nil - 2 - pirrolidino-pentano, sus diastereoisomeros y sus sales.
IL39100A IL39100A (en) 1971-03-30 1972-03-28 4-hydroxy-1-phenyl-2-pyrrolidino-pentane derivatives,their preparation and pharmaceutical compositions containing them
CA138,421A CA967968A (en) 1971-03-30 1972-03-29 4-hydroxy-1-phenyl-2-pyrrolidinopentane, their diastereomers and salts and processes for their preparation
GB1488872A GB1379959A (en) 1971-03-30 1972-03-29 Pyrrolidino hydroxy-pentanes
ZA722161A ZA722161B (en) 1971-03-30 1972-03-29 Improvements relating to 4-hydroxy-1-phenyl-2-pyrrolidino-pentane
BE781423A BE781423A (fr) 1971-03-30 1972-03-29 Le 4-hydroxy-1-phenyl-2-pyrrolidinopentane, ses diastereo-isomeres et sels et son procede de fabrication
AT273972A AT310730B (de) 1971-03-30 1972-03-29 Verfahren zur Herstellung des neuen 4-Hydroxy-1-phenyl-2-pyrrolidino-pentans, dessen Diastereomeren und Salzen
NL7204230A NL7204230A (https=) 1971-03-30 1972-03-29
FR7211260A FR2132244B1 (https=) 1971-03-30 1972-03-30

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712115281 DE2115281A1 (de) 1971-03-30 1971-03-30 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung

Publications (1)

Publication Number Publication Date
DE2115281A1 true DE2115281A1 (de) 1972-10-19

Family

ID=5803191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712115281 Pending DE2115281A1 (de) 1971-03-30 1971-03-30 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung

Country Status (11)

Country Link
US (1) US3801592A (https=)
AT (1) AT310730B (https=)
BE (1) BE781423A (https=)
CA (1) CA967968A (https=)
DE (1) DE2115281A1 (https=)
ES (1) ES401273A1 (https=)
FR (1) FR2132244B1 (https=)
GB (1) GB1379959A (https=)
IL (1) IL39100A (https=)
NL (1) NL7204230A (https=)
ZA (1) ZA722161B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8304613D0 (en) * 1983-02-18 1983-03-23 Ici Plc Chemical process
WO2025072342A1 (en) * 2023-09-26 2025-04-03 Bexson Biomedical, Inc. (hetero)arylalkylamine n-methyl-d-aspartate receptor (nmdar) antagonists and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH344418A (de) * 1955-07-01 1960-02-15 Thomae Gmbh Dr K Verfahren zur Herstellung tertiärer Amine

Also Published As

Publication number Publication date
NL7204230A (https=) 1972-10-03
ZA722161B (en) 1973-12-19
AT310730B (de) 1973-10-10
US3801592A (en) 1974-04-02
BE781423A (fr) 1972-09-29
FR2132244B1 (https=) 1975-08-01
IL39100A (en) 1975-05-22
ES401273A1 (es) 1975-02-01
FR2132244A1 (https=) 1972-11-17
IL39100A0 (en) 1972-05-30
CA967968A (en) 1975-05-20
GB1379959A (en) 1975-01-08

Similar Documents

Publication Publication Date Title
DE2558501C2 (https=)
DE2446010A1 (de) 4-(monoalkylamino)benzoesaeurederivate und verfahren zu ihrer herstellung
DE2542881B2 (de) Razemische oder optisch aktive Benzylalkoholderivate, Verfahren zu ihrer Herstellung und sie enthaltende therapeutische Zubereitung
EP0003029B1 (de) Neue 2-Oxo-1-pyrrolidinessigsäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Arzneimittel und deren Herstellung
DE2641388C3 (de) 3',4'-Didesoxykanamycin B-N-methansulfonsäuren und deren Alkalimetallsalze sowie diese Verbindungen enthaltende pharmazeutische Präparate
DE1568759C3 (de) Verwendung von 4-Guanidino-butyramid bei der Behandlung von diabetischen Zuständen
DE1940566C3 (de) 1- (2-Nitrilophenoxy)-2-hydroxy-3äthylaminopropan, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE2115281A1 (de) 4-Hydroxy- l-phenyl-2-pyrrolidino-pentan, dessen Diastereomere und Salze und Verfahren zur Herstellung
DE3438244C2 (https=)
DE3016549C2 (de) 2-Isopropylamino-5-halogenopyrimidine, Verfahren zu deren Herstellung und diese enthaltende therapeutische Zusammensetzungen
DE1925351A1 (de) 3-Isopropylnorbornanamine und Verfahren zu ihrer Herstellung
DE2248741B2 (de) 5-Phenoxy-und 5-Thiophenoxy-2(lH)-Pyrimidinone
DE2610501A1 (de) 1,4-disubstituierte piperazinverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3146867C2 (https=)
DE2530515C2 (de) 4- bzw. 7-Hydroxy-4,5,6,7-tetrahydrothieno-[3,2-c] bzw.[2,3-c] pyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittelzubereitungen
DE2213271C3 (de) Neue oxazolidine
DE1518199C3 (https=)
DE2421165A1 (de) N-substituierte dihydroxyphenylaethylamine
DE2244737B2 (de) H-o-ChlorphenyD-2-tert-butylaminoäthanol, Verfahren zu dessen Herstellung und Arzneimittel auf dessen Basis
DE2327193C3 (de) N-(Diethylaminoethyl)-2-methoxy-5methylsulfonylbenzamid, seine Salze, Verfahren zur Herstellung dieser Verbindungen sowie diese Verbindungen enthaltende Arzneimittel
DE1957783A1 (de) Neue substituierte Arylhydrazino-pyrroline,-tetrahydro-pyridine und -tetrahydro-7H-azepine sowie Verfahren zu deren Herstellung
DE3405172C2 (https=)
DE2320967C3 (de) Neue Benzylamine, deren physiologisch verträgliche Salze, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE1793590C3 (de) N-Cyclopropyl-N-propargyl- 1-aminoindan, dessen Salze und Arzneimittel auf dieser Grundlage. Ausscheidung aus': 1443403
AT259574B (de) Verfahren zur Herstellung der neuen 7-(Picolylamino-alkyl)-theophylline und deren Säureadditionssalzen